Figure 1 Ark taunts Chinese mRNA technology
Chinese fangzhouzi is not unfamiliar with this person, as a so-called "anti-counterfeiting expert", Fangzhouzi turned a deaf ear to all kinds of counterfeiting phenomena in foreign countries, but always stared at some internal affairs of our country to speculate on the wind and shadows, and repeatedly attacked China's system and meritorious scientists, the ass was crooked, after the domestic chaos could not be mixed, Fang Arkzi fled overseas, in California, the United States to continue the anti-China cause, especially in the new crown epidemic, but also to Zhong Nanshan, Chen Wei, Li Lanjuan and other heroes to do their best to smear things. Recently, Fang Arkzi made insulting remarks on foreign social platforms, saying that "the gap between China and the United States in messenger RNA technology is larger than that of chips, and they still want to produce their own mRNA vaccines?"
Figure 2 Mexican foreign minister quickly punches him in the face
On May 11, Mexican Foreign Minister Ebrad said that Mexico plans to conduct phase 3 clinical tests of a new coronavirus pneumonia (COVID-19) vaccine in May. This vaccine was developed by China, which uses mRNA (messenger ribonucleic acid) vaccine technology, which directly swollen the face of Fang Arkzi, and foreign social platform netizens also mocked it under the state of this article, and Fangzhouzi did not respond, it seems that Fangzhouzi was speechless.
Although the Ark Zi and the Hate Nationalist Party were quickly punched in the face, it has to be admitted that there is still a sentence in the words of the Ark Zi, that is, "messenger RNA technology is the culmination of molecular biology technology", and all the countries that can break through and produce vaccines with this technology are the top countries in molecular biology in the world.
To understand this problem, you need to first know what is messenger RNA (hereinafter referred to as mRNA), when the virus invades the human body, the human body needs to use antibodies to destroy it, and the antibody needs to accurately identify the DNA of the virus in order to launch an attack on it, for this reason, the human body uses RNA to observe the characteristics of the virus's DNA, and record it, and finally becomes an mRNA that can guide the formation of antibody proteins, precisely because mRNA acts as a messenger to transmit viral DNA in this process. So it's also called messenger RNA.
Explain clearly what is mRNA, you can understand what is mRNA vaccine, the technology is directly using artificial way to encode specific viruses, create the corresponding mRNA, and then inject it into the body, guide the human body to produce the corresponding antibodies, so that all viruses can be prepared in advance vaccines, before they infect people, let the population have antibodies, as Musk said, mRNA can directly encode viruses, is the future of medicine, The mRNA vaccine produced by Pfizer and Modena is the stinging protein encoding the new crown virus, inducing the human antibody response, and then all virus invasions with spike protein will be recognized and eliminated by antibodies, and if the new crown virus does not have spike protein, it will just lose the ability to infect people, so Pfizer and Modena vaccines have achieved an amazing effect of 95% effective protection.
Figure 3 mRNA schematic
Compared with traditional vaccines, mRNA vaccine advantages are very prominent, manifested in high protection efficiency, strong safety and short preparation cycle, strong anti-mutant virus ability and other characteristics, at the beginning of the outbreak of the new crown virus, mRNA vaccine did not become the preferred choice for vaccine preparation in China There are many reasons, mainly because this new vaccine has no successful precedent before, there is a huge risk of failure in research preparation, China in order to relatively high preparation success rate chose a simple technology but a higher preparation success rate of inactivated vaccine, however, With the continuous mutation of the new crown virus and the expansion of the world epidemic, the preparation cycle, production speed, and update speed of inactivated vaccines are somewhat inadequate, and in the situation that Europe and the United States and other countries have been successful, China has also begun to prepare for the development and production of mRNA vaccines, and foreign countries are different, because China's epidemic relies on administrative intervention and control methods have been controlled, so there is more time to calmly produce this vaccine.
Figure 4 Chen Wei and Zhong Nanshan both laid out mRNA
The first time I saw the news of China's research and production of mRNA vaccines was on March 6, 2021, and the team engaged in the research and development of the vaccine was led by two of the top experts in China's medicine, Major General Chen Wei of the Academy of Military Sciences and The People's Hero Zhong Nanshan, Mexican Foreign Minister Ebrad announced that China's entry into the third phase of clinical this mRNA vaccine is the result of Major General Chen Wei's team, the vaccine is cooperated by the National Nano Center and Major General Chen Wei. The addition of the National Nano Center is because one of the most critical preparation objects in the mRNA vaccine is the artificial nano "eggshell", the substance can safely bring the mRNA into the body, the principle is: once the bare RNA enters the body, it will be immediately attacked by the RNA cleavage enzyme in the human body and decomposed, and to protect the mRNA, it is necessary to wrap a layer of "eggshell" in its outer layer, the most common practice is to use nano fat balls, that is, the so-called artificial nano "eggshell", which is the most difficult point in the preparation of the vaccine. The mRNA vaccine developed by Major General Chen Wei's team entered phase III clinical trials in Mexico, which also means that "China has broken through this most difficult eggshell manufacturing technology", of course, the ignorant Ark once thought that "only one place in California can produce this substance" and "China absolutely cannot make it".
In the southern end of the Chinese mainland, the team led by Academician Zhong Nanshan has also achieved outstanding results in the preparation of mRNA vaccines, during this year's two sessions, Academician Zhong team members, Chinese Academy of Sciences Guangzhou Institute of Biomedicine and Health Research Fellows, Guangzhou Ruibo Biological Founder Zhang Biliang made a special report on the team's mRNA preparation project, in the report he mentioned that China's independent research and development of mRNA vaccines not only broke through the key technology, but also used artificial nano "eggshell" technology is more advanced, It can be stored in an environment of 2 to 8 degrees Celsius for half a year and is still effective, while the Pfizer and Modena vaccines in the United States can only be stored at minus 70 degrees Celsius because the artificial nano "eggshell" uses a viral vector, compared with the Chinese vaccine. For the mRNA research and development in the "eggshell", Zhang Biliang also mentioned that "the domestic mRNA has carried out the modification of molecular-scale RNA "carving", the manipulation of three-dimensional conformation, has completely independent intellectual property rights, and has completed the preclinical research stage such as animal poison testing", although in the end, it seems that the overall progress is delayed compared with Major General Chen Wei, but outstanding progress has been made.
Compared with the vaccine has just been developed, now the national attitude to the mRNA vaccine has undergone a large degree of reversal, mRNA as a revolutionary molecular biology technology, the future can be applied in the field is definitely not limited to the new crown virus, the technology can produce almost all infectious disease vaccines, currently known to have "HIV-I vaccine, rabies vaccine, Zika virus vaccine, influenza virus vaccine", followed by rare diseases, tumor therapeutic vaccines, leukemia vaccines, HPV vaccines, Tumor immunotherapy enhancers play a major role, and in the future, it is possible to directly use this technology to produce cancer vaccines, which shows how powerful it is.
Figure 5 Progress of mRNA technology of Sysmic microorganisms
In fact, the development of domestic mRNA technology is definitely not an urgent construction after the outbreak of the new crown in 2020, in 2016, the Returnee Doctor team in the United States created the Development of mRNA drugs in Shanghai Zhangjiang Medicine Valley, as of today, there has been a big breakthrough in the new crown vaccine, personalized tumor vaccine, and has also begun to layout in tuberculosis vaccines, influenza vaccines and other vaccines. It is also worth noting that Suzhou Aibo Biological, the founder of the company is an executive from Modena Company, the company was founded with the entire team of Modena, rich experience in mRNA technology, there are many other outstanding companies, the results achieved are also very fruitful, the domestic mRNA technology level is far from what Fang Ark Zi said", "The gap between China and the United States is even larger than that of chips", and the inferiority complex disease and hate of the country disease of Fang Ark Zi and others is the time to cure it well.