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Since the end of the 1980s, we have conducted 15 years of arduous research with the goal of developing special, high-efficiency and low-toxic chemical drugs for livestock and poultry, and successfully developed the national first-class feed additive chemical drug "quinosterone".
The mechanism of action of "quinohrenone" is to promote a secondary increase in the production of anabolic and metabolic growth hormone, thereby accelerating animal growth; inhibit the growth of pathogenic microorganisms in the digestive tract, preventing or reducing the occurrence of disease.
Tip: Announcement No. 2428 of the Ministry of Agriculture stipulates that on November 1, 2016, colistin sulfate premix and premix (fermentation) products will all replace "veterinary drug added word" with "veterinary drug word", which will not be added to long-term feed and cannot be used as an additive!
"Quinosterone" has very low toxicity (oral LD50 mice are 14398mg/kg, rats are 8179mg/kg), nearly non-toxic; have a strong antibacterial effect, can effectively inhibit Staphylococcus aureus, Escherichia coli, Klebsiella, Proteus, Avian Pasteurella, Typhoid fever, Dysentery bacillus; the growth promotion effect is obvious, effectively improving the feed conversion rate.
Since the solubility range and solubility of "quinosterone" are small and are almost not absorbed by the digestive tract (more than 93% are excreted in prototypes), there is almost no residue in edible animal tissues. Animal excrement also does not adversely affect the environment.
In the 15 years of developing new drugs, Zhongmu has repeatedly conducted research and experiments on the following items: pharmacological tests of quinosterone (including in vitro bacteriostatic tests, pharmacokinetics tests, weight gain tests), toxicology tests (including acute toxicity, accumulation toxicity, subacute toxicity, chronic toxicity, and tertiary tests), isotope labeling tests (the first domestic case of veterinary drug development), residue tests, animal transmission and breeding tests, environmental toxicity tests (including environmental toxicity tests for plants and fish), Stability test of APIs and master mixes. The chemical structure of quinoletones was determined by infrared spectroscopy, ultraviolet spectroscopy, nuclear magnetic resonance spectroscopy, mass spectrometry and elemental analysis.
Through clinical trials in Guangdong, Hubei, Shandong, Shaanxi, Shanxi, Gansu, Liaoning, Jilin, Shanghai, Beijing, Henan and other provinces and cities, as well as review tests (pharmacology, toxicology, residues, generations, structural confirmation) in the process of declaring new drug certificates, the data is proved to be true and reliable.
Antibacterial properties of quienone
Livestock and poultry are mainly due to respiratory and urinary tract infections caused by gram-negative bacteria and Staphylococcus aureus. It is especially suitable for intestinal infections such as chicken diarrhea, typhoid fever, paratyphoid fever, avian cholera, livestock and poultry E. coli disease, etc.
Fish all kinds of bacterial enteritis, ascites, abdominal swelling, bacterial sepsis, furuncle disease, red skin, rotten gills and so on.
Sea cucumber skin disease and other bacterial diseases of aquatic animals.
Growth-promoting properties of quienone
Supplement: Because colistin (also known as polymyxin) is a medical, veterinary dual drug, medical use of injections, there is a certain degree of nephrotoxicity, so the medical use is less, most of the human body infected bacteria are more sensitive to it, so the value of the medical is irreplaceable; the existing discovery of long-term addition of feed will lead to a large number of drug-resistant bacteria, the drug resistance characteristics have the risk of transmission to the human source, causing risk to human health, so the breeding field no longer uses it as an additive to promote growth, retaining its therapeutic drug characteristics.