Vitamin D₃ is a fat-soluble vitamin, and according to surveys in cities of different dimensions on the mainland, vitamin D deficiency is prevalent in the population. Recently, the internationally renowned journal "Pharmaceutics" published a study on the pharmacokinetics of vitamin D₃ oral nano spray - "Development In Vivo Evaluation of a Novel Vitamin D3 Oral Spray Delivery System", which discusses a new type of vitamin D₃ nano emulsion oral spray dosage form, and focuses on its utilization in vivo.
来源于《Pharmaceutics》期刊--《Development In Vivo Evaluation of a Novel Vitamin D3 Oral Spray Delivery System》
The study was jointly conducted by the School of Pharmacy of Fudan University and Shanghai Jialanhai Nanotechnology Group. This important discovery opens up new perspectives and possibilities for effective vitamin D₃ supplementation and health sciences.
This study found that vitamin D₃ oral spray has a clear advantage in bioavailability
In the study, a detailed pharmacokinetic study was carried out on the bioavailability of vitamin D₃ oral nanospray. The pharmacokinetic properties of administration by oral spray and conventional oral administration were compared using New Zealand white rabbits as animal models. The results of the study showed that the highest concentration (Cmax) of 25-OH-VitD3 in the plasma of rabbits administered with the spray form was 1.7 times higher than that of oral administration. The highest concentration (Cmax) of 25-OH-VitD3 in the plasma of rabbits administered with oral spray was significantly higher than that administered orally, reaching 139.93 ng/mL, while the Cmax of oral administration was 55.88 ng/mL. In addition, the peak time to arrival (Tmax) of oral spray administration was 26 hours, which was shorter than the 40-hour period of oral administration. These data suggest that vitamin D₃ oral sprays have a clear advantage in bioavailability, increasing drug concentrations in the body faster and more effectively than traditional delivery methods.
Comparison of the mean values of vitamin D₃ concentration-time curves in the oral administration group and the oral spray administration group
Comparison of the mean values of the 25-OH-VitD3 concentration-time curves between the rabbit oral administration group and the oral spray group
Improve vitamin D supplementation
Studies have shown that a new type of vitamin D₃ nanospray has the characteristics of small particle size, round and spherical sample morphology, uniform surface and size, and can maintain long-term stability under specific conditions. Pharmacokinetic studies have shown that the oral spray is superior to traditional oral administration in terms of bioavailability, especially in terms of drug absorption rate and concentration of active metabolites in plasma. This finding has important implications for improving vitamin D supplementation therapy, especially in patients with malabsorption or dysphagia.
To shape the quality of the industry with rigorous science, Jialanhai Group continues to conduct scientific research and demonstration
In addition, Jialanhai Group and Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, have carried out a clinical study on the application effect of two vitamin D₃ administration dosage forms in vitamin D-deficient children, which will provide an effective reference for exploring the choice of vitamin D supplement types for Chinese children. From the perspective of industry development, the importance of rigorous scientific argumentation is far higher than that of marketing competition. Based on clinical evidence, Jialanhai Group adheres to scientific and evidence-based products, realizes product nano upgrades, dosage form upgrades and drug delivery system upgrades, and launches the NanoSynergy technology platform, which has been providing "NanoSynergy Inside" technology empowerment business for the American nutrient brand Spray For Life for 20 years, and also providing technology empowerment business for the nano small molecule nutrient brand Anali. Jialanhai Group is committed to combining nanotechnology and oral spray forms with nutrients to create more value for the health of Chinese people by means of a new nutrient delivery method that is easy to spray and fully absorbed.