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In the reproductive center, if you want to say who is the boss, it must be the elderly women, if you encounter obesity again, it is even more difficult, and we can always see them in women who have failed to test tube many times.
In the end, how to improve the pregnancy rate, many sisters also use a variety of methods, such as coenzyme Q10, growth hormone, etc., spend a lot of money, but the effect is not satisfactory.
Traditional Chinese medicine is a Chinese characteristic, but it has been widely criticized in clinical practice because there is no randomized multi-center clinical controlled trial.
But today, the drug introduced to you by Sister Quanjie has been confirmed to be of great help to fertility through randomized controlled trials in 19 reproductive centers across the country.
It is a kidney-nourishing pill!
01 2022 study: Significantly increased the rate of live births with fresh transplants
This is a multicenter, large-scale, placebo-controlled, randomized pilot study published in the authoritative American journal of obstetrics and gynecology, Obstetrics and Gynecology.
In this study, 2,265 patients were randomly selected from 2,580 patients, 1,131 of whom were assigned to the Kidney Nourishing Pill group and 1,134 patients to placebo, with similar characteristics between the groups.
During the study, the treatment group received 5 grams of Zi Kidney Fertility Pills, and the placebo group received the same dose of placebo three times a day.
The results showed that the live birth rates in the Zi Kidney Fertility Pill group and the placebo group were 26.8% and 23.0%, the implantation rates were 36.8% and 32.6%, the biochemical pregnancy rates were 35.5% and 31.1%, and the clinical pregnancy rates were 31.2% and 27.3%, respectively.
There were no significant differences between the two groups in terms of miscarriage rates, maternal or neonatal complications.
As explained above,
The main mechanism of this is that ovulation induction may lead to ovarian hyperstimulation, causing rapid changes in sex hormones and disrupting the physiological balance of human hormones.
Previous animal studies have shown that the Kidney Nourishing Pill has the potential to improve endometrial receptivity and oocyte quality.
02 2023 study: New subgroup analysis shows greater effect
This study still uses data from 2022, and on the basis of the improvement of the overall pregnancy rate, the researchers tried to analyze the subgroup.
The subgroup analysis focused on the two major infertile groups in fertility centers: older and obese women, and how drug use affected them compared to controls, and the study was published in Frontiers in Endocrinology.
The results showed that for elderly patients, the pills significantly increased the implantation rate (30.4% vs. 22.4%) and clinical pregnancy rate (33.0% vs. 23.1%)
We can find that
For overweight and obese patients, the implantation rate (37.4% vs. 28.9%), clinical pregnancy rate (34.5% vs. 25.0%), and live birth rate (29.1% vs. 20.6%) were significantly higher in the Nourishing Kidney Pill group.
In the same way, we can find that
Note that the older patients in this study were predominantly overweight and that these two subgroups would not have had satisfactory outcomes in any fertility center.
In 2019, China developed the first clinical practice guidelines on assisted reproductive strategies specifically for elderly women, which argue that
So now, the researchers have found
It is worth noting that through this study found that, although not statistically significant,
According to the first expert consensus on weight management in overweight/obese infertility patients in China, it is recommended that overweight/obese infertile women lose weight before pregnancy.
Obesity can lead to a series of reproductive endocrinological changes, including a decrease in ovarian reserve, a decrease in the quality and quantity of oocytes and embryos, and a decrease in endometrial receptivity.
Therefore, the Kidney Fertility Pill may provide a complementary treatment option for assisted reproductive strategies for overweight and obese patients.
03 The theoretical basis of traditional Chinese medicine for fertility pills
The Kidney Nourishing Pill is the experience prescription of Professor Luo Yuankai, a well-known Chinese medicine scientist in China, and has been rated as a national protected variety of traditional Chinese medicine, and has now entered the national essential drug list.
In the theory of traditional Chinese medicine,
Clinical studies have shown that
The main pathogenesis of recurrent spontaneous or habitual miscarriage is kidney deficiency and qi and blood weakness.
From the perspective of the cubic principle and drug composition,
The key to pregnancy is the abundance of kidney qi, if the kidney qi is insufficient, Chong Ren can not be related, and the qi and blood are out of balance, it is difficult to conceive.
Kidney deficiency can be due to congenital kidney qi deficiency or acquired damage, and kidney yin deficiency and kidney yang deficiency can occur due to the influence of yin and yang in the constitution and the cause.
After IVF, the fetal element has been concluded, the fetus is left and stayed, and the prosperity and decline of the kidney are seen.
Generally, oral administration is required on the fifth day of the week for IVF cycle, which is conducive to increasing the number of high-quality eggs and improving the clinical pregnancy rate.
For patients who have failed in the test tube, they can take the Kidney Nourishing Pill for 3 menstrual cycles before egg retrieval or embryo transfer (stop the drug on the 1st to 4th day of menstruation).
In conclusion, through two clinical studies on these data, we can find that Zi Kidney Fertility Pill has a significant effect on the pregnancy rate of IVF fresh cycle transplantation, and the second study further pinpoints the largest beneficiary group.
However, the current research sample still has some shortcomings, the elderly population is the most difficult bone to gnaw in the reproductive center, and further research on the elderly population may bring more gains, we can look forward to it together!
Solemnly declared
The content published on this account is only for information sharing, this account does not do any form of marketing promotion, and the views of the article cannot be directly used as medical diagnosis or health intervention suggestions. Talk to your healthcare provider before taking any preventive or curative measures.
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On the way to hold the baby, I am willing to accompany you through the most helpless years
——THE END——
bibliography
[1] Effects of the Zishen Yutai Pill Compared With Placebo on Live Births Among Women in a Fresh Embryo Transfer Cycle: A Randomized Controlled Trial. Obstet Gynecol. 2022 Feb 1; 139(2):192-201. doi: 10.1097/AOG.0000000000004658. PMID: 34991130; PMCID: PMC8759541.
[2] Effects of the Zishen Yutai Pill compared with placebo on pregnancy outcomes among women in a fresh embryo transfer cycle: a Post Hoc subgroup analysis of a randomized controlled trial. Front Endocrinol (Lausanne). 2023 Nov 21;14:1196636. doi: 10.3389/fendo.2023.1196636. PMID: 38075073; PMCID: PMC10703301.
[3] Zhao Ying, Cao Lei, Luo Songping.Clinical application and research of nourishing kidney pills[J].World Chinese Medicine,2011,6(04):318-319.