The 2017 Nobel Prize in Physiology or Medicine was awarded to American scientists Jeffrey C. Hall, Michael Rosbash, and Michael W. Young, in recognition of their discovery of the "molecular mechanisms of biological rhythms", the three laureates discovered the world's first circadian clock gene. Since then, circadian rhythms have developed into a popular area of study.
Circadian rhythm refers to the endogenous biological rhythm that exists in all living organisms for nearly 24 hours, also known as the biological clock [1], which plays an important role in maintaining the body's internal physiological functions, such as sleep, body temperature, metabolism, etc. [2].
Nowadays, many people often stay up until 1-2 o'clock in the morning, the circadian rhythm is disrupted, the sleep time is less, the sleep quality is low, and the skin condition will be very poor, so I often hear people say that you can improve the skin condition by sleeping beauty sleep, so does beauty sleep really make sense? Nature has the answer.
Recently, the international academic journal "Nature Cell Biology" published a research paper related to the phenomenon of biological clock, which shows that if the circadian rhythm is disrupted, collagen fibers will be accumulated, the structure will be disordered, the elasticity will be weakened, and the strength will be reduced, thus affecting the quality of the skin.
Collagen is the main component of the extracellular matrix, which is the most abundant protein in the human body, accounting for about 30% of the total protein, mainly found in the skin, bones, cartilage, teeth, tendons and other tissues of animals [3], which can maintain the elasticity and support of the skin, making the skin look firmer and more elastic.
The researchers observed three kinds of collagen fibers with different diameters in the Achilles tendon of mice through electron microscopy, D1 (<75nm), D2 (75-150nm) and D3 (>150nm), and through analysis and statistics, the researchers found that the number of D1 and D2 with smaller fiber diameters was higher during the day, peaking about 7 hours after the start of light, and slowly decreasing in the dark environment, reaching a trough after 4 hours; D3, which has the largest fiber diameter, is the opposite, indicating
The researchers further explored the specific causes of this phenomenon and found that the transport of procollagen from the endoplasmic reticulum to the cytoplasmic membrane is regulated.
Researchers have found circadian phenomena in mouse models of collagen synthesis and degradation: In addition, cathepsin K (CTSK) is also expressed in a circadian rhythm, which rhythmically degrades collagen and maintains collagen homeostasis.
In addition to affecting skin collagen, circadian rhythm disorders have been found to be associated with a range of diseases, such as sleep disorders, depression, and tumors [4].
Circadian rhythm disorders are very common in modern society, and the above research reminds us that staying up late not only hurts the body and mind, but also affects the collagen in the body.
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[1] Fu Cong, Yu Huan, Chen Yunfei. ADVANCES IN PHYSIOLOGICAL SCIENCE, 2019, 50(1):6.DOI:CNKI:SUN:SLKZ.0.2019-01-008.
[2] Mohawk JA, Green CB, Takahashi JS. Central and peripheral circadian clocks in mammals[ J]. Annu Rev Neurosci, 2012, 35: 445-462.
[3] Wan Chunyan, Wang Yinghua, Wu Yuanjuan, et al. Application status and development prospect of collagen in food[J].China Food and Nutrition, 2008(9):3.)
[4] Wang Chunyan. Journal of Clinical and Pathology, 2015, 35(4):5.