Compare 10 Thai fruits to improve the effects of Alzheimer's
When it comes to Thailand, I always want to come to a trip that can be walked away. In addition to the beautiful scenery and friendly tourism culture, Thailand's fruits are even more addictive, after all, Thailand is known as a tropical fruit kingdom. In addition to being delicious, do these tropical fruits have any medicinal value? Studies have shown that Thai mulberry fruit extract from Chiang Mai has anti-Alzheimer's effects.
Mulberry Chiang Mai, Thailand
Thai pineapple
The ethanol extract of Thai pineapple (Ananas comosus, Prima) has the effect of combating the cognitive dysfunction caused by scopolamine.
Thai papaya (papaya)
Thai papaya has a neuroprotective effect in oxidative stress-induced Alzheimer's disease.
Thai guava
The aqueous extract of guava has the ability to combat neurological dysfunction caused by hydrogen peroxide.
Thai durian
Thai durian (variety Monthong) can inhibit the degradation of acetylcholinesterase by neurotransmitters and the aggregation of Aβ protein, while also having a neuroprotective effect against the toxicity of Aβ protein.
Thai Mango (Namdokmai)
The ethanol extract of Tai Mang (variety Namdokmai) also has the effect of fighting mild neurological disorders.
It seems that these Thai fruits all have certain neuroprotective functions, so which fruit is most effective for Alzheimer's disease?
Professor Uthaiwan Suttisansanee of the Institute of Nutrition, Mahidol University, Thailand, published the paper "Mangifera indica 'Namdokmai' Prevents Neuronal Cells from the journal Pharmaceuticals
Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a
Drosophila Model of Alzheimer'", which compares the effects of 5 Thai fruits (including 10 varieties) in combating Alzheimer's disease.
The 5 fruits include glass (varieties Phulae and Pattavia), papaya (varieties Khaekdum and Khaeknuan), durian (varieties Monthong and Chanee), guava (varieties Kimju and Keenok), and mango (varieties Kaew and Namdokmai).
5 fruits, 10 varieties
Mango Namdokmai has the strongest inhibitory effect on acetylcholinesterase, butyrylcholinesterase and β secretase (the key enzyme produced by Aβ). In addition, mango Keaw and guava Kimju also have a strong inhibitory effect on three key enzymes. The researchers selected these three fruits for subsequent experimental analysis.
The researchers analyzed the content of polyphenols and flavonoids in these three fruits and found that mango contained higher gallic acid, while guava contained higher quercetin and isomeric litin.
How about the cytotoxicity of these three varieties of fruits, they all have certain toxicity at high concentrations of 72 hours, but they are basically non-toxic at low concentrations (100 μg/ml). Mango, in particular, is the least toxic.
In hydrogen peroxide and Aβ1-42-treated PC12 cell species, Namdokmai also plays the best cellular protection role.
The authors also used a Fruit Fly AD model to study the effects of these three fruits, Namdokmai in inhibiting the activity of BACE1, reducing the concentration of Aβ1-42 and improving the ability of Drosophila to behave, which can be comparable to the positive drug donepezil.
Overall, mangoes have the best effect on improving Alzheimer's disease, followed by guava.