April 25, 2022
It is the 36th "National Child Vaccination Day" in mainland China.
This year's promotional theme is
"Timely vaccination to protect life and health"
Babies from birth
It is necessary to prevent diseases by vaccinating various vaccines
Vaccination is for every child
"Health Umbrella"
presently
School-age children on the mainland
15 vaccines are available free of charge
Recently, the National Health Commission announced
Immunization Procedures and Instructions for Vaccine Children in the National Immunization Programme
The age at which vaccination is initiated for some vaccination doses is listed
Today, on the occasion of National Child Vaccination Day
Zhongliujun took everyone to understand the time of children's vaccination
Of course some children for various reasons
Especially in children with genetic metabolic disorders
Normal vaccinations are not possible
Friends will ask
These are the children who have genetic metabolic diseases
Why can't I get vaccinated normally?
How should I get vaccinated?
Genetic metabolic disease is a general term for diseases caused by hereditary biochemical metabolic defects, due to related gene mutations caused by enzyme activity defects, the accumulation of substrates and bypass metabolites in its metabolic pathways, and the reduction of physiologically active substances, resulting in the body's biochemical reaction and metabolite chaos, resulting in a series of clinical diseases. There are many kinds of genetic metabolic diseases, common 500 to 600 species, a total of more than thousands of species, the number of single diseases, relatively rare, but the overall incidence is higher. According to the abnormal classification of metabolites, genetic metabolic diseases include amino acid metabolism abnormalities, organic acid metabolism abnormalities, carbohydrate metabolism abnormalities, fatty acid oxidation disorders, urea circulation disorders, of which phenylketonuria and methylmalonic acidemia are relatively common diseases in mainland China.
Children with genetic metabolic diseases have a weak ability to stabilize and balance metabolism in the body, and even a very slight infection may cause metabolite disorder in the originally fragile body, which will aggravate the disease. To this end, preventing infection helps to reduce morbidity and mortality, so vaccination is necessary for such children.
However, vaccination is an active immunization process, for children with genetic metabolic diseases may induce the onset of disease or aggravate the disease, there are also cases of acute metabolic crisis after vaccination of children with genetic metabolic diseases at home and abroad, so the vaccination of children with genetic metabolic diseases needs to be individualized. For children with genetic metabolic diseases, there are currently no uniform vaccination guidelines, and vaccine instructions are not covered.
Therefore, vaccination should be considered to prevent the corresponding infection under a comprehensive assessment of the child's physical condition and the risk of vaccine-preventable diseases.
Mainland China for patients with genetic metabolic diseases that are relatively common in clinical practice
Different vaccination strategies are adopted depending on the type of disease
▲Recommendations for vaccination of some genetic metabolic diseases
It should be noted that some children will have adverse reactions such as rash, fever, redness and swelling after vaccination, but serious adverse reactions rarely occur.
Public awareness and controversy about vaccine safety has increased, mainly because of the increase in the vaccination population, so that the adverse events that occur after vaccination increase with the expansion of the vaccinated population.
These adverse events included true responses to vaccines and conjugal events associated with vaccination.
While there may be public concerns about the safety of vaccines, the benefits of vaccination far outweigh the risks compared to the risks of the diseases these vaccines prevent.
▲Manifestations and treatment of major vaccine adverse events
There is evidence that the current COVID-19 vaccine is acceptable in the safety, immunogenicity and efficacy of children aged 3-17 years, and children with metabolic diseases can refer to the table above for various types of vaccines or live attenuated vaccines.
This article guides the experts
Director of Pediatric Xiao Xin
Doctor of Medicine, Professor, Chief Physician, Doctoral Supervisor. Sun Yat-sen University's "100 Talents Plan" introduces talents
He is good at the diagnosis and treatment of pediatrics, common neonatal diseases and intractable diseases. He has rich clinical experience in the diagnosis and treatment of pediatric genetic metabolic diseases, neonatal intensive care, neonatal asphyxia resuscitation, neonatal mechanical ventilation, and neonatal total enteral nutrition.
Academic Appointments:
Vice Chairman of the Genetic metabolic Disease Expert Committee of the Neonatology Branch of the Chinese Medical Doctor Association, Vice Chairman of the Pediatrician Branch of the Guangdong Medical Doctor Association, Vice Chairman of the Perinatal Medicine Branch of the Guangdong Medical Association and Leader of the Hereditary Metabolic Disease Group, Vice Chairman of the Expert Committee of the Guangdong Eugenics and Fertility Association, Standing Committee Member of the Science Branch of the Guangdong Medical Association, Standing Committee Member of the Neonatology Branch of the Guangdong Medical Association, Standing Committee Member of the Pediatric Branch of the Guangzhou Medical Association, Standing Committee Member of the Guangzhou Neonatology Branch, He is a member of the National and Guangdong Natural Science Foundation Project Review Committee, a member of the Medical Malpractice Appraisal Committee of Guangdong Province and Guangzhou Municipality, and an editorial board member of the Chinese Journal of Perinatal Medicine, the Chinese Journal of Practical Clinical Pediatrics, the Chinese Pediatric Emergency Medicine, and the Chinese Journal of Contemporary Pediatrics.
Research and Teaching:
Mainly engaged in the clinical and scientific research of neonatal critical illness and genetic metabolic diseases, he has presided over 1 national health research institute (NIH) fund, 4 national natural science foundations, 1 national doctoral research start-up fund for returning to China, 5 natural science foundations of Guangdong Province, and 1 talent fund project of the "100 Talents Program" of Sun Yat-sen University, and published more than 100 papers (including 6 high-level papers);
He is the chief editor of "Neonatal Mechanical Ventilation Therapy", "Neonatal Critical Care Therapy", "Practical Pediatric Critical Care Medicine" and "Practical Neonatal Critical Care Medicine", and participated in the compilation of the "Twelfth Five-Year Plan" pediatric undergraduate and graduate textbook "Pediatrics" in ordinary colleges and universities across the country.
Visiting hours: Monday morning, Wednesday morning, Friday morning;
Wednesday afternoon at the Prestige Clinic
Pediatrics Hao Hu Chief Physician
Doctor of Medicine, Chief Physician, Doctoral Supervisor
Academic appointments: Deputy Director of the Department of Pediatrics, Director of the Department of Neonatology, Deputy Director of the Laboratory of Genetic metabolic diseases, Outstanding Young Medical Talents of Guangdong Province, and Powerful Young and Middle-aged Doctors of Guangdong Province.
Academic expertise: Long-term engaged in neonatal critical care rescue, genetic metabolic disease diagnosis and treatment. He has carried out research on the immune mechanism of neonatal necrotizing enterocolitis, gene editing therapy for genetic metabolic diseases, presided over more than ten projects such as the National Natural Science Foundation of China, and published more than 60 papers in academic journals at home and abroad.
Academic positions: Member of the Birth Defect Prevention and Control Professional Committee of the Science Branch of the Chinese Medical Association, Youth Member of the Neonatal Professional Committee of the Chinese Medical Doctor Association, Vice Chairman of the Youth Committee of the Neonatal Branch of the Guangdong Medical Association, Standing Committee Member of the Neonatal Professional Committee of the Guangdong Medical Doctor Association, Vice Chairman of the Child Health Professional Committee of the Guangdong Preventive Medicine Association, Vice Chairman of the Neonatal Professional Committee of the Guangdong Provincial Grassroots Medical Association, Vice Chairman of the Neonatology Professional Committee of the Guangdong Clinical Medical Association, Member of the Standing Committee of the Neonatal Science Branch of Guangzhou Medical Association. He is a visiting associate editor of Frontiers in Genetics magazine, an editorial board member of The Chinese Journal of Contemporary Pediatrics, and a corresponding editorial board member of the Chinese Clinical Journal of Practical Pediatrics and the International Journal of Pediatrics.
Visits: All day on Monday, Wednesday morning
Editor-in-Charge: Zhang Yuanquan
Preliminary: Daisy.com
Review: Jian Wenyang
Final Judge: Zhu Changping
Approved release: Li Hanrong
Part of the article is based on public health and preventive medicine
Some of the pictures come from the Internet