Most of the sisters who do IVF are quite afraid of biochemical pregnancy because it always "happens invisibly". Such a mysterious biochemical pregnancy is more like being masked, and today we will recognize it.
What is biochemical pregnancy?
In a nutshell, biochemical pregnancy is the absence of clinical pregnancy. In general, normal pregnancy can not only detect HCG, but also B ultrasound can see the gestational sac, and although the blood HCG is greater than 25U/L or the HCG in the urine suggests positive, the pregnancy sac cannot be detected under ultrasound, indicating that the embryo has not implanted in the uterus and the pregnancy has been terminated.
What are the causes of IVF biochemical pregnancy?
Now that IVF technology has matured, many infertile couples hope to be able to help themselves get babies through IVF assisted reproductive technology, but IVF does not guarantee 100% success, and some of them produce biochemical pregnancies after embryo transfer. So, what are the reasons for the biochemical pregnancy that occurs after ivy infant embryo transfer?
01
Embryonic factors: poor embryo quality, abnormal chromosomal abnormalities, the embryo is affected by drugs or infected by pathogens.
02
Ovarian luteal insufficiency: the luteum is not very good, it affects the secretion of progesterone, if the secretion of progesterone is too small, then it is very easy to cause the embryo to implant normally in the uterus, resulting in biochemical pregnancy.
03
Uterine factors: the uterus is the cradle of the baby, if the uterus is not good, it will directly affect the implantation of the embryo, resulting in implantation failure. For example, endometritis, uterine fibroids, etc., are easy to cause implantation problems, resulting in biochemical pregnancy.
04
External factors: If pregnant women often smoke and drink alcohol after embryo transfer, or are exposed to chemicals that should not be exposed, it is easy to cause implantation problems and biochemical pregnancy.
What about recurrent biochemical pregnancy?
Reproductive medicine experts say that the common cause of biochemical pregnancy among hospital visitors is poor embryo quality, or chromosomal abnormalities in both spouses or one of them.
Case
Liu Na (pseudonym), 37 years old, had two spontaneous abortions and never became pregnant again in five years. In 2018, Liu Na and her wife went to a top three general hospital in Wushi to hope to carry out fertility treatment through assisted reproductive technology. Two cycles of treatment were performed over the course of one year using the first and second generation IVF techniques, with a total of two transplants, both ending in a failed biochemical pregnancy. In October 2020, Liu Na and her wife came to our hospital, and they were treated by Han Tingting, director of the Reproductive Medicine Center. Considering that Liu Na's fallopian tubes have been removed and combined with Liu Na's other physical indications, Director Han used the first generation of IVF technology to perform fertility treatment, and after transferring two embryos, she was biochemically pregnant again. 2 spontaneous abortions, 3 biochemical pregnancies, coupled with the age of 37 years old, Liu Na wants to get pregnant has been very difficult. Director Han considered whether there was a problem with the embryos and suggested that they use the third-generation IVF technology for treatment. On November 15, 2021, doctors transplanted a normal blastocyst selected by the third generation IVF technology for Liu Na, and Liu Na successfully conceived. Now that the baby is 4 months old, various examinations show that the baby is developing normally. Reproductive medicine experts said that Liu Na and his wife did not find genetic problems in the examination, but in the previous treatment of the first and second generations of IVF, due to their age, the quality of the eggs would have declined, coupled with the free combination of sperm and eggs without selection, it is likely to form low-quality embryos and be prone to biochemical pregnancy.
The third generation of IVF technology is to carry out strict screening of sperm and eggs before embryo transfer, select sperm and eggs with complete morphology, strong fertility ability and good quality for combination, and then conduct genetic testing on embryos before transfer to confirm that the embryos are of good quality and do not carry pathogenic genes after transfer. The third generation of IVF technology will greatly improve the success rate of pregnancy and achieve the purpose of eugenics. Our hospital is the first reproductive medicine center in Xinjiang to be approved as a preimplantation genetic diagnostic technology (third-generation IVF technology) qualification, and has successfully conceived more than 15,000 IVF babies. Stay away from birth defects and make it a dream to have a healthy baby!