This is the 3590th article of Da Yi Xiao Nursing
In recent years, the Liver Kingdom has found a particularly large number of subjects with abnormal liver function. The scholars of the Liver Committee were very worried about the functional status of the people, and specially organized a large-scale gathering to discuss the causes of abnormal liver function and countermeasures. Countless livers gathered together, and the famous liver scholars divided them into 7 groups, namely: viral hepatitis group, metabolic fatty liver group, alcoholic fatty liver group, drug-induced liver injury group, autoimmune liver disease group, genetic metabolic liver disease group and difficult liver disease group.
The university chaired the meeting, and the speech showed the concern about the current situation, "In recent years, our liver disease kingdom has found more and more abnormal livers, which have increased by 59.9% this year and last year, this situation is very serious, so that one day, we will all become 'organ disease men'." At present, the level of human scientific and technological development is changing rapidly, and in the future, artificial livers may be developed to completely replace us, and then we will face the disaster of extinction. As the saying goes, if the liver has no far-reaching worries, it must have near-term worries! Today's meeting is dedicated to the issue of our dysfunction. You can open your mind and talk about the current situation. ”
Representatives of the various groups spoke enthusiastically.
Representative of the viral hepatitis group
The culprits in our group are viral infections, including hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus and other hepatophilic viruses, these guys are very fond of our liver environment, after invading the human body, mainly live in the liver to multiply, causing our lesions; other viruses, including some respiratory and enteroviruse infections, can also cause liver dysfunction, often after the owner has a respiratory or gastrointestinal virus infection. Of course, some other pathogenic microorganisms, including bacteria, parasites, spirochetes and other infections, can also cause abnormal liver function.
Metabolic fatty liver group is represented
Most of our hosts are fat, or guys who don't weigh too much but have a thick waistline. In addition to abnormal liver function, these people are often accompanied by 1 or more of metabolic disorders such as hyperlipidemia, hypertension, high uric acid and hyperglycemia, or even if these metabolic abnormalities are not accompanied by these metabolic abnormalities, but if left uncontrolled, it is easy to develop such a disease state in the future. The biggest feature of these people is that they are "delicious and lazy", and they can't control their mouths and can't open their legs.
Alcoholic fatty liver group representatives
Our masters all drank, some of them were alcoholics who could not quit at all, some were toiling men and women who had to drink with their customers for work and livelihood, and some were emotional slaves who were emotionally or unhappy with their feelings or work and used wine to pour sorrow. We were thus spoiled by their long-term soaking in alcohol.
Representatives of the drug-induced liver injury group
Our masters either have to take a lot of medicine every day because of illness, or because of a disease that clearly may damage the liver, or because they take "health products" or take certain so-called "supplements" for health care purposes. As we all know, we are the detoxification plant of the human body, and the metabolism of drugs in the human body is inseparable from our liver, but too many drugs often overwhelm us!
Representative of the autoimmune liver disease group
Our hosts were relatively a niche group. There are more women, why do we get sick in these people, the specific mechanism is not fully understood, may be related to genetic factors, infection of some pathogenic microorganisms, certain poisons or drug effects, so that the human body has an abnormal immune response against their own tissues, we are also victims, was shot.
Representative of the hereditary metabolic liver disease group
Our masters do not have any bad habits, but their genes are born with pathogenic factors, such as genetic mutations or deletions, which make some substances or energy related to liver metabolism obstruct and cause abnormal liver function.
Representative of the Difficult Hepatology Group
We just called a miserable, the illness is not clear, in the end only a few brothers can find out the real reason, most of the people are either confused, or unclear and dead, think about it is heartbroken!
a university graduate
"Everybody's got a good talk. The rapid development of human science and technology, the past unclear diagnosis, can not be treated diseases can now be clearly diagnosed and treated, such as some viral liver disease, autoimmune liver disease, genetic metabolic liver disease and difficult liver disease; but the social problems brought about by scientific and technological progress can not be underestimated, such as great abundance of materials, people's physical labor is reduced, competition pressure increases, anxiety about health is unprecedented and the flood of various famous health care products, etc., resulting in many lifestyle-related diseases, such as metabolic fatty liver disease, Alcoholic fatty liver disease, drug-induced liver disease, other prominent diseases such as diabetes, cardiovascular and cerebrovascular system diseases and cancer, etc., these can be called 'modern social diseases'. So let's talk about the current state of human treatment for our dysfunctional abnormalities? ”
At present, hepatitis A and E are generally acute infection processes that can be cured; chronic hepatitis C also has curable drugs, after 3-6 months of treatment, more than 98% of patients can be cured; chronic hepatitis B is still difficult to completely cure, but by continuously and effectively inhibiting viral replication, so that the disease does not develop, greatly improving the prognosis of patients, so that infected people and normal people live without being affected. As for some other viral infections, it is mainly symptomatic treatment.
For us, the most important treatment is to improve the diet structure, strengthen exercise, eat less greasy and high-calorie diet, especially at dinner as little as possible or low-calorie diet; ensure more than half an hour of aerobic exercise every day, walking, running, swimming can be. Some people insist on it well, but quite a few people can't do it, which makes us extremely worried.
Alcoholic fatty liver disease, as the name suggests, is alcohol-induced liver disease, and the fundamental treatment measure is of course to quit drinking. If you quit drinking in time, the mild and moderate liver lesions that have formed can be reversed. But for a variety of reasons, it is difficult for some people to successfully quit drinking, resulting in our function deteriorating day by day, and eventually to the point of exhaustion.
For drug-induced liver damage, the basic treatment is of course discontinued. Stop the drug plus hepatoprotective symptomatic treatment, generally our function can be restored, but there are also some patients who may induce autoimmune liver disease after taking the drug, resulting in repeated abnormalities in liver function, which is more troublesome, and may need to take immunosuppressants to treat. Need to remind human beings, do not indiscriminately take health care products or supplements, if you must use, please use the products of regular manufacturers as much as possible, the safety will be better.
For us, most of us may be able to maintain a stable condition after treatment, but there are also some refractory patients who are not good at drug treatment, or liver lesions have been very serious before being found, and the treatment effect is often not good at this time.
What we are most sad about is that there is currently no cure for drugs, some diseases can be treated by substance substitution therapy, and some can be treated by expelling too much substance deposition, some patients have a good treatment effect, and some patients have a bad effect. There is no cure.
If you can find out the cause, the treatment of the cause can generally achieve good results, but some patients can not find out the cause in the end, so there is only one way to treat the symptoms, and the outcome can only be resigned to fate.
The university listened intently to everyone's speeches and continued to encourage, "Well, I can understand everyone's helplessness." In the current situation, what are the difficulties and challenges we face? ”
The biggest problem we are facing right now is low rates of patient discovery and treatment. Although chronic hepatitis C is now a curable disease, it has a low detection rate and a low treatment rate. Globally, the diagnosis rate of chronic hepatitis C patients is only 20% and the treatment rate is only 7%; the diagnosis and treatment rate of chronic hepatitis B is less than 10%. Therefore, how to find and diagnose chronic hepatitis C and B patients with infection is a serious practical problem that currently faces, which requires government policy and financial support, the intervention of disease control departments, the cooperation of patients and the participation of medical staff.
There are two difficulties we face: one is to maintain a healthy diet and proper exercise - control the mouth, open the legs, such things are easy to say, but it is not easy to do, quite a few people can not do it, which makes us extremely worried; the other is that many people have problems with the cognition of fatty liver, thinking that fatty liver is the liver to grow fat, there is no problem! The fact is that if the fatty liver is not intervened in time and effectively, liver disease will continue to develop to hepatitis, liver fibrosis, cirrhosis, and even liver cancer, and along with fatty liver diseases, it will be prone to diabetes, gout, cardiovascular and cerebrovascular system diseases and other problems.
It's too hard to quit drinking successfully! Some people drink the liver function to the point that they have exhausted and still can't stop. Watching these drunkards lead us step by step towards a hopeless future every day, I really want to be able to escape from such a body. Abstaining from alcohol is a very difficult personal problem, at the same time, it is also a family problem and a social problem, which requires strong self-restraint, as well as the encouragement of family members and the support of society. So how to use the strength of individuals, families and society to help people who are addicted to alcohol to quit drinking is the biggest challenge we face!
Stopping the drug is easier said than done. Some patients must take some drugs because of the disease, and some patients think that health care products, supplements and proprietary Chinese medicines are pure natural preparations, which are harmless to the human body, so the phenomenon of random use is still more prominent. Therefore, strengthening the public's science publicity and education, increasing the common sense of safe drug use, improving the cognitive level of rational drug use, and not abusing drugs, health care products, supplements and "pure natural preparations" are the challenges we face in the future!
Our biggest problem is that some patients with refractory autoimmune liver disease, or patients with advanced disease, do not work well with drug therapy. We can only hope that the development and progress of human science and technology and medical level can develop a radical cure drug as soon as possible.
Some mild hereditary metabolic liver diseases, the prognosis will be better, but there are also some patients, even if the diagnosis is clear, there is no effective drug treatment, can only be symptomatic treatment, the prognosis is difficult to say. For us, watching ourselves decay day by day without being able to do anything about it is also a kind of suffering. We can only hope that human technology is more developed, and there will be more accurate treatments in the future, such as gene therapy, of course, this may take a long time.
We are also hoping that the progress of medical science and technology and the improvement of human cognition of difficult liver diseases can clearly investigate the causes of our diseases, so that we will not live in vain.
"Today, everyone can speak freely, fully expressing our current dilemma that is not optimistic. I can understand everyone's helplessness. Our Liver Committee will always be committed to the cause of liver health, maintain communication and cooperation with human beings, strive to be the guardian of liver health, and strive for the common goal of liver health. I believe that only hard work will have a better future. ”
Author: Department II of Liver Disease, Shenzhen Third People's Hospital
Wang Fang