For cancer patients, the year 2021 that has just passed is undoubtedly a year of hope. Domestic anti-cancer injections were finally available, the research and development of anti-cancer boron drugs also entered a new level, and the US company Can-Fite announced a blockbuster news at the end of the year.
On December 20, 2021, Can-Fite announced that in its Phase II experiment with Namodenoson for liver cancer, a terminally treated patient had achieved complete remission (CR), which meant that the patient's cancer lesions had been completely cleared. In general, patients with advanced liver cancer can only live for another 10 months to a year or so, while the above patients have already lived for 5 years after receiving treatment.
Precision sniping, zero cancer cells
While modern medicine typically uses immunotherapy, targeted therapy, and TACE therapy to tackle cancer, Can-Fite has ingeniously built Namodenoson with an innovative therapy. Simply put, Namodenoson is a highly selective, oral small molecule A3 adenosine receptor (A3AR) agonist. It has little interest in normal cells and is only actively expressed in cancer cells. The result of active expression is to regulate specific signaling channels and induce apoptosis of cancer cells.
Referring to the disclosed information, Namodenoson has been in development for at least 8 years. Now that pharmaceutical companies have announced cases of cure, the industry is excited. "Complete remission is a very rare outcome in advanced liver cancer treatment," said Dr Michael Silverman, "and its significance is not only to extend the survival of liver cancer patients worldwide, but also to lead to a new direction for solid tumor treatment." ”
Anti-cancer generalist Namodenoson: More than just liver cancer
The industry's high praise is not out of thin air. Unlike the "anti-cancer needle" for a single disease, Namodenoson is not a "partial player". It is currently being developed for the treatment of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, with the prospect of more conditions in the long term.
The Global Cancer Statistics Report (Globocan2020) released by WHO in 2020 shows that the annual number of new liver cancer cases in China is as high as 410,000, and the number of deaths exceeds 390,000, most of which develop along the hepatitis-cirrhosis-liver cancer link. Namodenoson's indiscriminate attacks on hepatitis and liver cancer mean that it promises to make a huge difference for us.
Not so long ago, there was an equivalence between cancer and "incurable disease"; today, the era of "smelling cancer" is far away. Advances in biotechnology have made a huge difference in our lives. This change is not limited to patients, and even the aging that each of us has to face is being overcome by Coenzyme I ( the core substance of "Cylery") and so on.
Unlike the scientifically synthesized Namodenoson, Coenzyme I is an endogenous substance that is already present in our body, but it decreases with age. According to the frontier science popularization team "Time School", as early as 2017, in the University of Washington experiment, scientists found that supplementing the substance can drive bone density, muscle energy, telomere length and other indicators back to rejuvenation, which is equivalent to about 20% of the physiological age regression.
Over the years, the University of Tokyo, Baylor Medical College, Tsinghua University and other universities have organized middle-aged and elderly people to carry out experiments around the substance, with good results. Affected by this, its landing results "Saleray" were once popular, and even many people in China were obtained through Jingdong International. Referring to tens of thousands of feedbacks, the substance has brought about a lot of positive changes.
Cancer will be like a cold and can be easily cured
Pharmaceutical companies say they are already actively promoting the phase III experiment of Namodenoson, which is expected to be widely available soon. At the same time, scientists will further develop namodenoson applications in other fields.
With the widespread landing of scientific and technological achievements such as Namodenoso and Cylery, whether it is cancer or aging, perhaps it can become as easy to cure as a cold in the future. Until then, all we can do is maintain good habits and maintain good health. Of course, physical health is the best at all times. We want medical technology to advance infinitely, and we don't need to use it