With the continuous development of science and technology, human beings have begun to be no longer satisfied with the status quo, and gradually focus on the problem of life and death. Scientists are trying to crack the code of youth, and the true meaning of life expectancy seems to be getting closer and closer.
The authoritative journal "Rejuvenation" recently disclosed a blockbuster study by George Church, a professor of genetics at Harvard: GHRH gene editing intervention for 5 years, 64-year-old middle-aged people PhenoAge (physiological age) decreased by 44.1%, that is, physiological age decreased by 28.6 years.
Risking yourself? The subject of the experiment was actually a microbiologist
Professor Church is currently the originator of gene therapy and was selected as one of the eight scientific heros by New Scientist magazine in 2008. As the leader of the experiment, he invited a 64-year-old man to undergo GHRH gene editing for up to 5 years.
Interestingly, as the sole subject of the experiment, Brian Hanley himself is a microbiologist. He was so confident in GHRH gene editing that he risked his life and began a 5-year intervention on his own.
Fortunately, the results were more gratifying: the 64-year-old subject Hanley, PhenoAge clock age decreased by 28.6 years; the epigenetic age decreased by 6 years; immune cells, cholesterol, and blood lipid status were also partially changed. He himself also said: When he was 18 years old, due to a car accident, the 0.6 cmx1 cm x 2.5 protruding lump left on his right kneecap disappeared after 3 weeks of gene editing.
Although the dedication to science is admirable, for the experimental results, the first intervention elderly organization "Time School" in China has conducted an objective analysis: (1) Although the PhenoAge clock is a relatively authoritative measurement method, it is mainly used to measure all-cause mortality, cancer and other results, pointing to healthy survival, and does not indicate that life expectancy is elongated. (2) There is only one experimental sample, the number is too small, and the experimental data cannot fully stand. (3) Telomeres, which are closely related to survival time, are shortened by 0.9%, which is equivalent to 7 months of aging.
Professor Church remains convinced that there should be no upper limit to longevity
Although the experiment is biased to some extent and needs to be further explored, the first author of the paper, Professor Church, firmly believes that the life span should not be capped except for the cosmic explosion.
Indeed, as biotechnology continues to develop, the limit of human lifespan is not constantly being challenged: Guinness World Record holder Maba Gaoso lived 146 years, and Xinjiang elderly Alimihan Seyti lived 135 years. Such a figure, placed in the average life expectancy of only more than 40 years ago 60 years ago can not believe, but with the advancement of science and technology, it does exist.
Existence is reasonable, and the current leading anti-aging biologist Sinkri also expressed a similar view. He said: "Hundreds of laboratories around the world are committed to this, the tide is beginning to turn, anti-aging is no longer a marginal science. As far as the currently known scientific achievements are concerned, the human metabolite Coenzyme I discovered earlier by Experiments by Sinkre has matured and landed a dietary agent of the "Cylery" class, which has been stationed in Lidong for several years. In recent years, it has also received scientific research endorsements from various places, such as tsinghua-Peking University Life Joint Center, Keio University, and the University of New South Wales.
Even Sinkri himself is an admirer of the substance. He said that his family has been taking "Cylery" supplements for many years, his physiological age has decreased from 52 years old to 31.5 years old, and his father is in his 80s and still has the physical fitness to climb mountains and rocks, and is a regular visitor to the gym. The changes in his own life have given the academic community greater confidence. Scientific research papers related to this kind of substance are also as many as a thousand in the journals "Nature" and "Cell".
"Countless research teams are climbing the mountain of 'aging'"
Economics professor Linda Gratton wrote in her book "A Hundred Years of Life" that with the development of technology, it is a fact that everyone is 100 years old. And there are countless scientific research teams around the world who are climbing the mountain of "Wanzhu" and continue to achieve gratifying results.
Like Hanley, a microbiologist who "risked himself" in the above experiment, he firmly believes that genetic programming technology is constantly making breakthroughs. Through gene recomparation technology, American scientists have restored the somatic cells of 114-year-old people to a 0-year-old state. Of course, more than that, in addition to the above-mentioned "Cylery" dietary agent has matured, last year, Belgian scientists also used the "O2ARK" hyperbaric oxygen chamber to extend the telomeres of the 65-year-old by 25%, which is equivalent to physiological indicators of 20 years younger and other scientific research, all showing an eruption state.
I wonder what kind of technology will be in the future, which can truly open the door of the centenarian era?