From ancient times to the present, human beings' desire for longevity has never stopped. From Qin Shi Huang sending Xu Fu to the sea to seek "elixir of immortality", western Gilgamesh seeking "immortal grass", to the vigorous development of the field of life sciences today. thriving. Human beings' struggle against aging has not stopped, and the development of today's life sciences has given us some "weapons" to fight aging, and we have more confidence in the face of aging.
Two major weapons against aging: calorie restriction and rapamycin
The most effective and easiest anti-aging "weapon" available today is calorie restriction. Calorie restriction, as the name suggests, is to limit calorie intake, generally reduced by 25-50%, which is commonly known as "seven points full". It is worth noting that caloric restriction has an important premise, that is, normal nutrient intake must be guaranteed. Scientists discovered during the Great Depression in the United States in the last century that heat restriction can prolong life.
All along, scientists believe that calorie restriction is to inhibit aging by inhibiting mTOR protein complex 1 (mTORC1), mTOR protein is an energy and nutrient receptor, when it feels the external energy and nutrient deficiencies, that is, hunger, it will be inhibited, thereby adjusting various metabolism, telling cells to "save money", do not "waste", and clean out those "delicious lazy" senescent cells, so as to achieve the purpose of delaying aging.
Coincidentally, rapamycin is also a mTORC1 inhibitor, it was first used in Easter Island in the last century for antibiotics, but its immunosuppressive side effects made it launched the antibiotic stage, until 2006, scientists found that it can prolong life, which gradually brought it back to people's vision.
But scientists have found some strange phenomena, caloric restriction and rapamycin's effects are not exactly the same, such as sugar tolerance, calorie restriction can significantly improve sugar tolerance, which means that the body's ability to absorb and utilize sugar increases, but rapamycin is the opposite, will reduce sugar tolerance. It's all about suppressing mTOR, so why is there a difference in the effect? Scientists are also confused about this.
Calorie restriction life extension is not a suppression of mTOR
Recently, the research team at the University of Basel published an article in the sub-journal of Nature, and finally unveiled the mystery, they found that long-term calorie restriction and rapamycin can delay the aging of skeletal muscle, but the mechanism behind it is not the same. Calorie restriction does not rely on inhibiting mTOR, but in other ways to induce cells to "eat" themselves, thereby delaying aging.
In addition, the researchers also found that the combination of calorie restriction and rapamycin was more effective, and the mice had stronger muscle function and were more active. This study tells us that the combination of mTORC1 inhibitors + calorie restriction + exercise may be a more effective treatment for delaying muscle aging in the elderly, especially those with poor muscle health and inconvenient legs and feet.
Leg and foot inconvenience has a great impact on the lives of the elderly, so the importance of muscle health is self-evident. If muscle aging can be effectively delayed, then the quality of life and happiness of the elderly will be greatly improved. Not only the elderly, but for all people, muscle health is very important, it allows us to enjoy a better life.
Entering the centenarian era will not be too far away
Delaying muscle aging is not only mTORC1 inhibitors, calorie restriction, exercise these methods, supplementing WITH NAD+ precursors can also play a very good effect. Last year's large-scale clinical trials in China, the United States and Japan have proved that this NAD+ precursor can effectively improve muscle mass in middle-aged and elderly people. If you feel that the above methods are more painful, difficult to adhere to, you can also choose to adjust the diet to delay aging, Paipai for everyone to prepare a suitable for the Chinese stomach anti-aging recipe, due to the length of the article, the specific recipe will not be repeated, whether you want the recipe or share and discuss calorie restrictions, rapamycin and other content, you can find a Pai assistant: timepe10. The image below shows some of the information about the recipe.
Since the beginning of the 21st century, with the rapid development of life sciences, people's life expectancy has been greatly improved, according to the statistics of the world's WHO, the average life expectancy of the world population has increased from 66.8 years in 2000 to 73.3 years in 2019. It is believed that there will be more means to delay aging in the future, and it will not be too far away for human beings to enter the century-old era.
—— TIMEPIE ——