On December 28, Nandu reporter learned from Sun Yat-sen University that recently, the latest issue of the international journal of medical research", Science translational medicine, published an academic paper jointly researched by the School of Life Sciences, the Third Affiliated Hospital of the University, and the Zhongshan Hospital Affiliated to Xiamen University. Aiming at "Cracking Bacterial Resistance Strategies", the paper systematically describes the role of glutamine in improving the sterilization efficiency of antibacterial drugs and delaying bacterial resistance. The research team members introduced to the Nandu reporter that this discovery provides a new direction for the prevention and treatment of chronic, multi-drug resistant bacteria infection diseases.
To improve the bactericidal efficiency of existing antibacterial drugs, where should we start? Peng Xuanxian and Li Hui research groups, Bloomberg research groups, Zhang Tiantuo and Chen Zhuanggui research groups of the Third Affiliated Hospital of Sun Yat-sen University, and Yang Tianci Research Group of Zhongshan Hospital affiliated to Xiamen University jointly conducted research on this issue.
On December 23, the research team published a research paper titled Glutamine promotes antibiotic uptake to kill multidrug-resistanturopathogenicbacteria in the journal Science Translational Medicine, an international journal of medical research.
The paper elaborates on the efficacy and mechanism of action of exogenous glutamine in reversing bacterial resistance. Li Hui, a professor and doctoral supervisor at the School of Life Sciences of Sun Yat-sen University, is a member of the research team, and she introduced to the Nandu reporter that the study found that exogenous glutamine can promote the efficient removal of multi-drug resistant bacteria by a number of commonly used antibacterial drugs, thereby improving the bactericidal efficiency of antibacterial drugs and delaying the role of bacterial resistance.
The journal Science Translational Medicine is an important sub-journal of the internationally renowned journal Science, which focuses on the study of major issues in the field of translational medicine worldwide. Li Hui said that this paper is another important progress made by the team in recent years in the study of bacterial drug resistance, which provides a new direction for the prevention and treatment of chronic, multidrug-resistant bacteria infection diseases.
Nandu reporter learned that at present, the research results have obtained national and American invention patents, and Guangdong Litai Pharmaceutical Co., Ltd. will develop new drugs on this.
Written by: Nandu reporter Huang Xiaoyin
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