"DaLang, it's time to take your medicine." This is a line in the TV series "Water Margin", and now it is also a hot word on the Internet.
Does anyone know what the "medicine" Wu Dalang took was? If you know, you can leave a message in the comment area to tell everyone.
Hello everyone, I am Cai Huabing pharmacist of Southern Hospital, we are talking about poison arsenic today.
Speaking of arsenic, everyone is not unfamiliar, it is one of the most famous poisons. The crane top red, peacock bile, and arsenic that often appear in costume dramas are all frightening. In the real world, there is no shortage of examples of arsenic poisoning, according to research, Napoleon died of arsenic poisoning.
Napoleon in a hospital bed
One day, I was studying in the outpatient clinic, and a patient with chronic kidney failure from Hunan came to the clinic. He recounted the cause of his illness: their village was downstream of a mine, and because of the mining, the arsenic content in the local environment was very high. Every two months, arsenic is distributed to villagers to help them detoxify. However, he took the medicine, and the effect was not good, resulting in him now suffering from chronic kidney failure! Because I heard that Guangzhou Southern Hospital has academician Hou Fanfan, who is a top expert in kidney disease, so it is too far away to come to Guangzhou Southern Hospital for treatment, and seeing the Chinese medicine clinic is hoping to use Traditional Chinese medicine to assist treatment.
Arsenic, the chemical component arsenic trioxide, the arsenic poisoning that this patient with chronic kidney failure said, is actually arsenic poisoning.
So ~
Let me answer these questions one by one.
Disulfide disodium dithio
Before answering these questions, let's take a look at arsenic.
Arsenic has been recorded as early as the Compendium of Materia Medica.
"Compendium of Materia Medica": "Remove wheezing and diarrhea, rotten flesh, erosion and rotting fistula." And "erodes the carbuncle flesh, withers and kills insects." ”
Arsenic stone It is a processed product that naturally produces ores containing arsenic minerals such as arsenic, poisonous sand or xionghuang. Also known as the Letter Stone. It is mainly produced in Jiangxi, Hunan, Guangdong, Guizhou and other places. arsenic The refined products of arsenic sublimation are white powders, that is, arsenic, which is more toxic.
1. Manifestations of acute gastroenteritis. Esophageal burning sensation, metallic odor in the mouth, nausea, vomiting, abdominal pain, diarrhea, renal insufficiency and even circulatory failure.
2. Nervous system performance. Headache, dizziness, fatigue, numbness around the mouth, general aches, irritability, delirium, delusions, muscle spasms of the extremities, confusion to coma, paralysis of the respiratory center and death in severe patients.
3. Damage to other organs. These include toxic hepatitis, myocardial damage, kidney damage, anemia, etc.
4. The clinical manifestations of hydrogen arsenide poisoning are mainly acute hemolysis.
In addition to the symptoms of neurasthenia, chronic arsenic poisoning is prominently manifested by a variety of skin lesions and polyneuroitis. At the same time, toxic hepatitis (rarely develops into cirrhosis), bone marrow hematopoietic dysplasia, numbness of the limbs, hypoesthesia and other peripheral nerve damage can occur.
Commonly used arsenic drugs include penicillamine, dimercaptosulfon sodium, or dimercaptobutyl disodium.
Although the probability of this happening is extremely low, if you encounter it, the residents near the mining area are not it!
Antidotes to acute arsenic poisoning, commonly used, include penicillamine, dimercaptosulfa sodium or disodium dimercaptobutyrin, should be used as soon as possible after confirmed arsenic poisoning. In addition, it is necessary to give patients oxygen in time, as well as symptomatic and supportive treatment. Chronic arsenic poisoning can use intravenous sodium thiosulfate to help arsenic be excreted from the kidneys.
He said that it was an oral drug such as penicillamine, dimercaptosulfa sodium or dimercaptobutyrin disodium, after all, it was impossible to send the injection to the villagers themselves.
Leukemia patients
The answer is "yes."
45 years ago, arsenic trioxide (ato) became a special drug independently invented in China and the world's first special drug for the treatment of acute promyelocytic leukemia (apl), and until now, it is still one of the most common first-line drugs for the treatment of apl.
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