What did a 45-year-old look like a 25-year-old do right?

This article is about 2800 words and takes about 5.5 minutes to read

Two days ago, one of my sisters was on fire because she looked like Qiu Shuzhen when she was young, and there were rumors on the Internet that she looked young and cute, and she was actually 46 years old... Of course, my sister-in-law is not so old, but the actual age of 30+ is still the envy of many people compared with the "visual age" of 20+.

Ten years ago, some netizens thought that I was in my forties, and some people called me Master Brother, and it turned out that she was five years older than me...

But until now, I've used basic skin care, sunscreen, and haven't done anything extra to take care of my face. However, this time, I was threatened by netizens to "depowder" (bushi), and I made up my mind to study where I was "old"!

1

Why does the appearance not match the actual age?

There will be a general understanding of the appearance of people of different ages, and compared with this general appearance cognition, some people just look younger and some people appear more mature.

Genes matter

It sounds a bit frustrating, but it's true.

Time and light are the two main causes of skin aging. Time aging is natural aging, which is a program written in genes. The telomeres at the end of the chromosome predetermine the number of times the cell can divide before aging and die, and every time the cell divides, it shortens a little until the cell ages and dies...

If you are born with good skin and a high initial score, then reducing the same "time" will naturally appear younger than others.

In addition, whether cumulative damage to genes and proteins can lead to premature aging and death of cells also depends on the repair system. If your body's ability to repair is strong, even if the "damage" to the skin is the same or even more, it will not cause premature aging and death of cells. [1]

External factors are equally important

Don't see that genes are important, just give up lying flat completely, and external factors are equally important.

For ordinary people who have not won the genetic lottery, it is better than who has less harm to the skin. If you continue to "demonize", the skin will "reward" you with accelerated aging.

Skin aging is a complex biological process that, in addition to genetic factors, is influenced by a variety of factors such as the environment (ultraviolet rays, mechanical stress, etc.), hormonal changes, and metabolic processes (the generation of active chemicals such as reactive oxygen species, sugars, and aldehydes). [1]

Photoaging, another major type of skin aging, is a prolonged (multiple) exposure of the skin to ultraviolet rays, and this photolaotage can cause the skin to age prematurely.

Look at the classic photo of the driver's facial skin below, left and right are their own faces, one side is always sunburned, the other side is not sunburned, 28 years later, the difference is huge.

A 69-year-old driver who has driven a truck for 28 years, compared with the left and right faces, UVA through the window of the car for a long time to illuminate the left side of the face, resulting in significant photoaging. | Image references[2]

Twins with the same genetic starting point, working and living environments are similar, one smoking, one not smoking, the degree of facial aging also has a significant difference. [3]

The two photos above are smoking twins who can be seen with extensive deep wrinkles, pigmentation, scattered pigmentation, and moderate sagging skin on her face. The following two are non-smoking twins, and although there are also mild to moderate photoaging phenomena (fine wrinkles, scattered pigmentation spots, mild pigmentation and sagging), the facial aging is significantly lower than that of her smoking sister. | Image from references[3]

In addition, the collagen in the dermis saccharide reaction with free sugars will lead to changes in skin protein function or even complete loss, skin loss of elasticity, wrinkles, and dull skin tone.

And expression lines, sleep lines are related to mechanical pressure, like I have very obvious crow's feet, head wrinkles, that is, the muscles of these two parts repeatedly contract and squeeze the skin, with the increase of age, skin elasticity weakens, and eventually becomes a permanent wrinkle. Sleep lines are associated with various pressures on the facial skin when lying on the side and prone. [4]

(A) A frontal and (B) side shot of a 58-year-old woman, (C) a sleep wrinkle, (D) a side sleep simulation showing how sleep wrinkles are produced. | Image from references[4]

2

What can I do on my own?

The reason for the "old face" has been found! Naturally, you know what to do to prevent "old age".

Sunscreen: Effective physical sunscreen + proper use of sunscreen.

Healthy lifestyle: quit smoking, eat more fruits and vegetables, eat less high-sugar and high-fat foods, help the body antioxidant, reduce the saccharification reaction, reduce the level of inflammation, etc.

Reduce excessive stretching of the epidermis: Pay attention to expression management, and sleep peacefully can effectively reduce expression lines and sleep lines.

And although I do a good job of sun protection, I don't smoke, I have eaten enough fruits and vegetables, but I have not slept for less than 7 hours for a long time, I am too busy to ensure regular exercise, and since I have done the media, I have eaten a lot of unhealthy snacks because of the pressure of work...

However, even if I can do not do anything harmful to the skin in the future, it is only to prevent the aging caused by external causes, and the natural aging and photoaging of the skin have appeared, in addition to going to medical beauty, there is no way to remedy it every day?

3

Anti-aging ingredient in the C position: A alcohol

Friends who pay attention to skin care must be familiar with A alcohol, which is the C position of anti-aging ingredients in the skin care industry.

Why Aol?

A alcohol is also called all-trans retinol or all-trans vitamin A alcohol, generally referred to as retinol or A alcohol, this anti-old family also has A acid, A ester, A aldehyde, but eventually in the skin to convert into A acid to play a role.

Image from references[5]

A acid improves the photoaging effect caused by ultraviolet rays, and at present, the FDA approved for the treatment of photoaging is 0.02% A acid. [1]

Why not use A acid directly, you ask? Because it is too irritating for everyone to tolerate, it is currently only used as a prescription drug for acne, keratosis, and photoaging.

A alcohol can not only be converted into A acid, recent studies also believe that A alcohol can also directly activate the A acid receptor in the skin to achieve anti-aging effect, and the conversion of A alcohol to A acid also greatly reduces the irritation of A alcohol.

The preliminary data research stage of the facial anti-aging work is completed, and the next step is to select specific products. I remembered that my friend Skincare Guru Uncle Xin once recommended an A-alcohol product, HBN's Retinol Tightsing Night Cream. It is said that HBN is a domestic brand that has begun to make A alcohol relatively early, and has a good reputation in the composition circle, and ingredient parties like Dr. Lilac have repeatedly recommended it.

Moreover, unlike the common A alcohol products on the market, one of the core themes of his star anti-aging product is the "double A alcohol formula", which uses the "quick effect" of A alcohol and the "sustained release" of A ester, which also makes the effect more durable under the premise of ensuring the effective concentration of the product.

Naturally aging, A-alcohol can also be effectively improved

The effect of A acid in improving photoaging has been recognized, so what about the effect of improving natural aging?

The researchers brought together people over the age of 80 for a randomized, double-blind controlled trial. The researchers selected the skin on the inside of the upper arm for the test, because the skin here is basically not illuminated, can eliminate the interference of photoaging, basically natural aging.

The test group was applied with 0.4% A-alcohol emulsion and the control group was applied with ordinary lotion. After 24 weeks of testing, A alcohol can effectively improve the fine wrinkles caused by natural aging, and also observed a significant increase in collagen and glycamine polysaccharides (components of the dermis layer, which has a moisturizing effect, hyaluronic acid is a kind of glycosamin polysaccharide), which is one of the reasons why A alcohol can reverse the skin atrophy caused by natural aging.

Comparative photographs of the appearance of the inner upper arm of 2 representative subjects at the beginning of the trial and at the end of the study (A and B; E and F). C and D, G, and H are pictures that enlarge the rectangular areas in A and B, E, and F by a factor of 3.5, respectively. | Image from references[6]

Research is indeed very effective, but how does a specific product actually work in the real world?

HBN is very confident in its own products, and together with Lilac Doctor, the world's leading third-party authoritative testing agency conducted a efficacy test, and concluded that it is significantly effective in reducing fine lines and tightening skin.

Seeing this, I was immediately more confident in improving my crow's feet and head wrinkles.

A alcohol is also not 100% perfect

Although A alcohol can reduce fine lines, improve wrinkles, regulate keratinocyte metabolism to smooth the skin, shrink pores, inhibit melanin formation, improve pigmentation, etc., A alcohol also has its defects.

Very unstable

A alcohol is very unstable, easily decomposed when exposed to light and air, and loses its biological activity. [1] Therefore, the carrier that "delivers" A alcohol is very important, and nanoparticles have been found to improve the stability, tolerance and efficacy of A alcohol.

HBN's exclusive patented "Gold Particles" encapsulate A alcohol, ensuring the high activity of A alcohol and also reducing irritation.

In addition, the product uses a black bottle body, which can maximize the protection of light, and the packaging design adopts a press bottle, which only needs to be lightly pressed on the top of the bottle when using, which protects the cleanliness and activity of the product in the bottle to the greatest extent.

Increases photosensitivity

A alcohol will increase the photosensitivity of the skin, so it is recommended to use it at night, and sun protection should be done during the day. HBN directly makes the product into a night cream, which is also to avoid everyone's negligence in using the wrong time.

Tolerance needs to be established

Although it is much less irritating than A acid, A alcohol still has a certain irritation. When using, be sure to start with products with low concentrations (0.1%-0.3%), try small doses (halve the normal dosage, reduce the frequency of use), and gradually adjust the dosage and frequency of use until you can use it normally.

If tingling, redness, peeling and other symptoms occur during use, you can maintain the current dosage, increase some repair products to relieve discomfort, and continue to increase the dosage after the skin is fully restored. However, if you experience discomfort the first time you use it, it is best to stop it, and when the skin is restored, switch to a lower concentration of product to re-establish the tolerance.

HBN's night cream is directly added with the repair ingredients pentaeramide and centella asiaticarin to promote the repair of the skin barrier and avoid problems such as barrier damage and tingling that may occur during use.

Finally, remind everyone that A alcohol must be used for a long time to see the effect, can not be used for a few days, weeks can not see the effect to say that A alcohol is useless.

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Resources

[1] Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348. https://doi.org/10.2147/ciia.2006.1.4.327

[2] Unilateral Dermatoheliosis. Retrieve April 3, 2022 from https://www.nejm.org/doi/full/10.1056/NEJMicm1104059

[3] Doshi DN, Hanneman KK, Cooper KD. Smoking and Skin Aging in Identical Twins. Arch Dermatol. 2007;143(12):1543–1546. doi:10.1001/archderm.143.12.1543

[4] Goesel Anson, MD, FACS, Michael A.C. Kane, MD, Val Lambros, MD, FACS, Sleep Wrinkles: Facial Aging and Facial Distortion During Sleep, Aesthetic Surgery Journal, Volume 36, Issue 8, September 2016, Pages 931–940, https://doi.org/10.1093/asj/sjw074

[5] Pettinelli P, Arendt BM, Teterina A, McGilvray I, Comelli EM, Fung SK, Fischer SE, Allard JP. Altered hepatic genes related to retinol metabolism and plasma retinol in patients with non-alcoholic fatty liver disease. PLoS One. 2018 Oct 31;13(10):e0205747. doi: 10.1371/journal.pone.0205747.

[6] Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007 May;143(5):606-12. doi: 10.1001/archderm.143.5.606.