The existing vaccine is still effective against the mutated strain, and the "dynamic zero clearance + precise prevention and control" is guarded

The new round of the epidemic has not subsided. According to the official website of the National Health Commission, at 0-24:00 on March 19, the mainland reported 1,737 new confirmed cases, of which 1,656 were indigenous cases, including 76 cases from asymptomatic infected people to confirmed cases. In view of the epidemic situation, the recent successive press conferences have released the latest policy signals: the mainland will continue to adhere to the general strategy of "external prevention of imports, internal prevention and rebound" and the general policy of "dynamic zero clearance", and make overall plans for epidemic prevention and control and economic and social development.

On March 20, Liang Wannian, head of the expert group of the National Health and Health Commission's Leading Group for Epidemic Response and Handling, said in an exclusive interview with CCTV that the spread of the mutated virus and the harm to human health are higher than those of ordinary influenza, and if dynamic clearance is not pursued, the spread of the social surface will continue to be connected and form a large-scale rebound.

The mutant strain has not completely escaped existing vaccines

A few days ago, 2 cases of new crown pneumonia deaths in Jilin have attracted attention, and it has been reported that their new crown pneumonia condition is mild, and the direct cause of death is basic disease. Notably, one of them was not vaccinated against COVID-19.

How effective are existing vaccines on the Ami kerong variant? On March 19, Zheng Zhongwei, head of the vaccine research and development special class of the scientific research group and director of the Science and Technology Development Center of the National Health commission, introduced at the press conference of the joint prevention and control mechanism of the State Council that recent studies at home and abroad have shown that although the Aomi Kerong variant has increased the risk of breakthrough infection for vaccinated people, the Aomi Kerong variant has not completely escaped the existing vaccine. Existing vaccinations, as well as vaccinations with booster needles, are still effective against the Omikejung variant.

Li Gang, former director of the Department of Surgical And Critical Care Medicine (SICU) of China-Japan Friendship Hospital and a member of the expert group on the prevention and control of the new crown pneumonia epidemic, said in an interview with the Beijing Business Daily reporter that it is necessary to increase the vaccination rate of vaccines and emphasize the strengthening of injections, and in the future, the research and development of new crown vaccines and drugs is the key to epidemic prevention.

"The existing COVID-19 vaccines, the main role is to reduce the mortality rate and severe conversion rate, the effect is not obvious in reducing the infection rate. The most ideal vaccine should be able to resist the virus and prevent human-to-human transmission after injection, such as polio vaccine, hepatitis B vaccine, etc. can achieve such an effect. Sars at that time, although it was also more fierce, but through the injection of vaccines, the human body quickly developed immunity, can have the ability to resist infection, and the virus will die. Li Gang said, "For the new crown virus, there is currently no vaccine in the world that can effectively prevent infection." The virus breaks through the barrier and enters the human body, and there are more opportunities for mutation. So now the most fundamental thing is to increase the research and development of vaccines, so that effective vaccines can keep the virus out of the body and reduce the possibility of mutation in order to be freed from the new crown epidemic, which is a law of public health events. ”

What is the progress of vaccine research and development in mainland China? Zheng Zhongwei revealed that positive progress has been made in the research and development of vaccines for the unit-valent and multivalent vaccines of the Aomi Kerong variant strain, and the preclinical research has been completed relatively quickly, and the declaration materials for clinical trials are being submitted to the national drug regulatory department on a rolling basis. "For example, inactivated vaccines, we have carried out unit valent, as well as Delta + Omikeron bivalent, as well as prototype strain + Delta + Omikeron trivalent vaccine research and development work, has basically completed the preclinical research, and has been manufactured to verify." Zheng Zhongwei said.

According to the official website of the National Health Commission, as of March 19, the mainland has reported a total of 3,222,868,000 doses of covid-19 vaccine. Next, the mainland will take a number of measures to promote vaccination, especially to increase the vaccination rate of the elderly.

The "cost utility account" of "dynamic zeroing"

Ms. Lu, a resident of Changzhou, Jiangsu Province, told the Beijing Business Daily reporter that her community has been relatively strictly controlled, "A family has a pass, the voucher goes out to buy materials, the card will have access time, the purchase of materials need to come back within two hours, in addition to which they cannot go out." ”

With the increase in the proportion of mild or asymptomatic infected people, whether the "dynamic zero" epidemic prevention policy will continue to become the focus of discussion.

"Many factors, such as foreign natural immunity and the mainland's requirements for opening up to the outside world, will make people think, is it necessary to abandon the strategy of 'dynamic zeroing'? Coupled with the fact that everyone now believes that the mortality rate and severe cases caused by the mutated virus are not high, then the concept will be relaxed. Li Gang told the Beijing Business Daily reporter, "But I think that the past epidemic prevention policy has proved to be effective, external prevention of imports, internal prevention of rebound, dynamic zero policy can not be relaxed, otherwise it will cause a relatively large impact on our production and life." ”

In response to some public and scholars' suggestions that the new crown caused by the Omiljung variant is equivalent to "big flu", Liang Wannian pointed out that it is too early to draw this conclusion. He said, "Because of its spread and harm to human health, it is higher than that of ordinary influenza." It may be that for an individual, the probability of severe illness after infection is decreasing; but in the group view, its transmission is fast, the infection rate is high in a short period of time, the absolute number of infected people is large, and the absolute number of severe diseases and deaths will be high. This is a great harm to a society and a country. ”

Liang Wannian said that dynamic zeroing has two meanings, one is the ideal state, the social surface has no patients, but the uniqueness of the new crown virus determines that we can not do it for the time being; the second is that once the epidemic occurs, it can be quickly identified and disposed of, cutting off the chain of transmission, and the social surface will gradually move towards dynamic zeroing as a whole. If dynamic zeroing is not pursued, the spread of social aspects will continue to be connected and form a large-scale rebound.

Earlier, Wang Hesheng, deputy director of the National Health Commission and director of the National Bureau of Disease Control and Prevention, also pointed out that the goal of "dynamic zero clearance" is to pursue the minimum social cost and control the epidemic in the shortest possible time. From the perspective of cost effectiveness, through dynamic zero clearance and precise prevention and control, the mainland has ensured the normal production and life of the vast majority of people in the vast majority of regions and the vast majority of the people, reducing the inconvenience caused by the epidemic and even psychological health problems.

Classified admission reduces medical stress

In the future, the mainland's prevention and control measures will continue to be strict. However, in terms of diagnosis and treatment, more targeted admission and treatment measures will be taken for different cases.

The latest release of the ninth edition of the diagnosis and treatment plan shows that cases will be classified and treated, ordinary, severe and high-risk factors of patients will be admitted to designated hospitals for treatment, and other mild cases and asymptomatic infected people will be isolated and managed to reduce the pressure on medical resources.

Li Xingwang, chief expert of the Infectious Disease Diagnosis and Treatment and Research Center of Beijing Ditan Hospital, said that Aomi Kerong has caused a large number of infected people in the short term, but clinically, the symptoms of these infected people are relatively mild, that is to say, more than 90% of patients are very mild cases, just some upper respiratory tract infection symptoms, in other words, these patients do not need to be hospitalized.

"In the face of such infected people who do not need to be hospitalized but are infectious, we must also manage them centrally, and admission to the hospital will cause a waste of medical resources, and more infected people will cause a run on medical resources, so it is necessary to establish isolation points, concentrate them in isolation points for isolation, and be managed by medical personnel, which is conducive to both the health recovery of patients and the control of disease transmission." Li Xingwang said.

Jiao Yahui, director of the Medical Administration Bureau of the National Health and Health Commission, introduced that the method of classifying and treating cases is more prominent, which highlights the scientific precision, and at present, the construction of square cabin hospitals is basically used to admit and treat mild cases and asymptomatic infected people.

At the same time, all localities will also guarantee medical services for special groups. At the 295th press conference on the prevention and control of the new coronavirus pneumonia epidemic in Beijing held on March 20, it was once again emphasized that the focus should be on ensuring medical services for special groups such as acute and critical patients, pregnant women, newborns, tumor patients, patients with renal failure, and patients with chronic diseases, so as to achieve both medical services and hospital infection prevention and control.

In terms of medical treatment, Ms. Lu is still troubled, she told the Beijing Business Daily reporter that her area requires yellow code and green code personnel to be concentrated in designated hospitals for treatment, but there are differences in the level of diagnosis and treatment in different hospitals, and some hospitals do not have the drugs that patients need, which leads to patients who can enter the hospital smoothly, but cannot be treated. She suggested that more convenient and reasonable measures can be taken to protect the needs of patients for medical treatment.

Beijing Business Daily reporter Yang Yuehan Lu Yinling