Atorvastatin calcium is a selective, competitive inhibitor of HMG-CoA reductase, atorvastatin calcium by inhibiting the biosynthesis of HMG-CoA reductase and cholesterol in the liver to reduce plasma cholesterol and serum lipoprotein concentrations, and by increasing LDL receptors on the surface of liver cells to enhance LDL uptake and metabolism. Eating atorvastatin calcium often should understand these six problems
First, how to take atorvastatin calcium?
Before starting treatment with this product, a standard low-cholesterol diet should be controlled, and a reasonable diet should be maintained throughout the treatment period. For patients with primary hypercholesterolemia and mixed hyperlipidemia, the recommended dose of calcium atorvastatin is 10 mg once a day, and the blood lipid level can be controlled. Significant efficacy is seen within 2 weeks of treatment and maximum efficacy is seen within 4 weeks of treatment. Efficacy is maintained with long-term treatment. The initial recommended dose for patients with heterozygous familial hypercholesterolemia is 10 mg/day, and the dose should be gradually adjusted to 40 mg/day at intervals of every 4 weeks, following the principle of individualization of dose. If the desired effect is still not achieved, the dose can be adjusted to a maximum dose of 80 mg/day or treated with a cholate chelating agent of 40 mg once daily. For patients with homozygous familial hypercholesterolemia, the recommended dose of this product is 10 to 80 mg/day. Atorvastatin calcium may be taken once a day at any time of the day and is not affected by meals. Patients with renal insufficiency do not need to adjust the dose
Second, what are the indications for atorvastatin calcium?
In patients with primary hypercholesterolemia, including familial hypercholesterolemia (heterozygostemic type) or mixed hyperlipidemia, if dietary therapy and other non-pharmacological treatments are not satisfied, the use of this product can reduce their total cholesterol (elevated T, elevated LDL cholesterol, elevated apolipoprotein B, and elevated triglycerides). In patients with homozygous familial hypercholesterolemia, atorvastatin calcium can lower total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). For patients with critical diseases such as coronary heart disease or coronary heart disease (such as diabetes, symptomatic atherosclerotic disease, etc.) with hypercholesterolemia or mixed dyslipidemia, this product is suitable for: reducing the risk of non-fatal myocardial infarction, reducing the risk of fatal and non-fatal stroke, reducing the risk of vascular reconstruction, reducing the risk of hospitalization due to congestive heart failure, and reducing the risk of angina
Third, what are the precautions for calcium atorvastatin?
1. Patients are advised to immediately report unexplained muscle pain, muscle tenderness, or muscle weakness, especially if accompanied by discomfort or fever, or when muscle signs and symptoms persist after atorvastatin calcium has been discontinued
2. The combined administration of calcium atorvastatin and fudeszecilic acid is not recommended, so it is recommended to suspend atorvastatin calcium therapy during fudescetine treatment
3. Atorvastatin calcium should be used with caution in patients with excessive alcohol consumption and / or a history of liver disease. If severe liver damage occurs with clinical symptoms and / or hyperbilirubinemia or jaundice, treatment is discontinued immediately
4. Atorvastatin calcium can increase HbA1c and fasting blood glucose levels
Fourth, what drugs does atorvastatin calcium interact with?
1. For patients using clarithromycin and itraconazole, the daily dose of atorvastatin calcium does not exceed 20 mg
2. For patients using tiranavir + ritonavir or grenamosevir + pirenosvir, or telapivir, the combined use of atorvastatin calcium should be avoided
3. For patients treated with saquinavir + ritonavir, derenavir + ritonavir, fosanavir, fosanavir + ritonavir or epalavir + gnazoprine, the daily dose of calcium atorvastatin should not exceed 20 mg
4. For patients taking agents of nelfenavir or perceptivine, the daily dose of atorvastatin calcium should not exceed 40 mg, and close clinical monitoring is recommended
5. Atorvastatin calcium should be avoided in combination with cyclosporine and grapefruit juice
6. Atorvastatin calcium should be avoided in combination with gefibrozil and other fibrates
7. Atorvastatin calcium should be avoided in combination with niacin
8. Atorvastatin calcium should be avoided in combination with CYP 3A4 inducers (eg, efaviren, rifampicin).
9. Atorvastatin calcium should be avoided in combination with digoxin
10. Atorvastatin calcium should be avoided in combination with oral contraceptives such as norethindrone
11. Atorvastatin calcium should be avoided in combination with colchicine
Fifth, what are the contraindications to atorvastatin calcium?
1. Patients with active liver disease (including persistent elevated levels of hepatic transaminases) are contraindicated
2. Patients with allergic reactions to any ingredient of this drug are contraindicated
3. It is contraindicated in pregnant and lactating women
4. This product is contraindicated in patients under 10 years of age
Sixth, what are the adverse reactions of atorvastatin calcium?
Common adverse reactions are: allergic reactions, angioedema, herpes, rhabdomyolysis, myositis, tendon rupture, dizziness, depression, peripheral neuropathy, pancreatitis, interstitial lung disease, liver enzyme abnormalities, rhabdomyolysis, and myopathy