Adult women to get pregnant, in addition to ovulation, fallopian tubes patency, normal uterus and other conditions, there is another important factor, that is, the function of the corpus luteum. Luteal insufficiency is one of the main factors contributing to female infertility. Once the luteal insufficiency can cause estrogen and progesterone insufficiency, resulting in endometrial dysplasia during the secretory stage, fertilized eggs are not easy to implant, early miscarriage and other conditions.
Hengjian Overseas pointed out that luteal insufficiency refers to the insufficient endocrine function of the yellow body formed after ovulation of the ovary, resulting in insufficient secretion of progesterone, insufficient transformation of endometrial secretion, ovulation blood, and is not conducive to implantation of fertilized eggs, which can lead to infertility or habitual abortion.
Patients with luteal insufficiency usually have no symptoms of discomfort. If clinical manifestations occur, they are mainly shortened menstrual cycles, frequent menstruation, infertility, or miscarriage, which occur mainly in the first trimester.
One: the harm of luteal insufficiency
1. Troubles caused by menstrual disorders.
Patients with luteal insufficiency will have menstrual disorders due to endocrine disorders, such as shortened menstrual cycles, frequent menstruation, menorrhagia, prolonged menstruation (up to 9-10 days or even longer), etc., which can make women miserable. If some women themselves are not in good health, there will be dysmenorrhea.
2. Luteal function will cause infertility.
Because the corpus luteum can not be atrophied and degenerated or incompletely degenerated and continues to secrete a small amount of progesterone, so that the endometrium can not be peeled off at the normal time, the premenstrual endometrium is still stuck in the early secretion stage, and the secretion response is not good on the body of the body is slightly curved, making it difficult for women to conceive, which will lead to the occurrence of infertility.
3. Increase the likelihood of miscarriage.
Women with luteal insufficiency cannot secrete enough progesterone, and even after normal conception, it is difficult to maintain conception, resulting in miscarriage and habitual miscarriage.
Two: the cause of insufficient luteal function
1. Follicle dysplasia
An important cause of luteal insufficiency is follicular dysplasia. Since luteal development is a continuation of follicular development, any factor that affects follicle growth and development will affect luteal function.
2, Hyper-hostinemia
Studies have shown that moderate amounts of prolactin are necessary to maintain normal luteal function. Too high prolactin can act directly on the β-hydroxysterol dehydrogenase of the ovaries and affect the synthesis of progesterone, resulting in shortening of the luteal phase, amenorrhea, galactorrhea, and infertility. About 40% of patients with luteal insufficiency have been reported to have hyperprolactinemia.
3. Endometriosis
In patients with endometriosis, corpus luteal insufficiency accounts for 25% to 45%. The relationship between endometriosis and corpus luteal insufficiency is not clear.
4. Flavinated unruptured follicle syndrome
With the development of reproductive endocrinology, the comprehensive application of real-time ultrasound and endoscopy has made the causes of infertility more detailed and specific. A study of luteal insufficiency reported that 47 patients with luteal insufficiency, laparoscopic and hormonal measurements confirmed LUFS in 16 cases, accounting for 34%.
5. Miscarriage
According to statistics, 83% of patients with miscarriage can resume ovulation, but their blood progesterone value is lower than normal, and once pregnant again, the miscarriage rate is high.
Three: What should I do if the luteal body is dysfunctional?
Many female friends will worry, what if the luteal body is dysfunctional? In fact, if it is generally not too serious luteal deficiency, then the most commonly used method is to supplement the lack of progesterone in the body, generally there are two methods of progesterone intramuscular injection and oral progesterone.
Four: Luteal insufficiency to do IVF?
For women with luteal insufficiency and not being able to conceive normally, IVF technology can help them conceive.
Because in the IVF process, because women need to promote the growth of follicles, it is necessary to supplement luteinizing hormone to make up for women's luteinizing insufficiency, and generally intramuscular injection or oral progesterone is used to indirectly make up for women's luteal insufficiency.
Progesterone drugs will be supplemented before and after ovulation induction according to the woman's physical condition. Progestin injections are required after IVF until pregnancy is confirmed, discontinued if there is no pregnancy, and continued progesterone care for 3 months if pregnant.
Five: Will it affect the success rate of test tubes?
Doctors will perform PGD/PGS genetic diagnosis or screening of these embryos, and the blastocysts examined are more viable and implantable than the average embryo. After transplantation, women are injected with progesterone to ensure smooth implantation of blastocysts, so patients with luteal insufficiency do not need to worry too much about the success or failure of the test tube.
Hengjian overseas reminder: If the progesterone value within the normal range will not affect the IVF, women should first adjust their own body, you can eat some soy foods to help improve the function of the corpus luteum, during IVF treatment, maintain an optimistic and upward attitude, because women are in a long-term nervous, lost, fearful mental state, which will lead to endocrine disorders, and finally lead to infertility.