The "liver" is located in the right upper abdominal cavity of the human body, which is the largest parenchymal internal organ of the body!
Not only that, but the liver is also the most complex of all internal organs, involving multiple systems!
According to the current clinical data, the most important work of the liver is metabolism and detoxification, biotransformation. But at the same time, the liver is also involved in endocrine balance, digestive system, coagulation system and other aspects.
Therefore, once the liver has a problem, the effect will also be systemic, and the more the liver function declines, the more obvious the patient's systemic symptoms will be.
Relevant research and investigation show that liver disease can affect the skin of patients, and when liver disease develops to a serious extent, such as the decompensated stage of cirrhosis and the middle and advanced stages of liver cancer, the patient's skin may have different symptoms. For example, the recent abnormal blackness of the face, around the eyes, around the lips, and the mucous membrane of the lips is often a manifestation of the arrival of liver disease!
So the question is, obviously there is a lesion in the liver, why does it cause the patient's skin to darken?
In fact, abnormal blackening of the facial skin, mucous membranes of the lips, around the lips and around the eyes caused by liver disease are all manifestations of the arrival of liver disease.
The patient's facial skin will become more and more dull, the face will be dark and dull, and the elasticity will become worse and worse, the skin will gradually dry and rough, and there will be obvious melanin accumulation around the eyes, just like panda eyes.
In severe cases, patients may even have a bronzed complexion. This is one of the common clinical manifestations of chronic hepatitis, cirrhosis and liver cancer.
Because the liver is involved in endocrine balance, severe damage to liver function can cause hypofunction of the pituitary gland and adrenal cortex. After the adrenal cortex function is reduced, it will lead to an endocrine disorder in the pituitary gland, and the secretion of leaf-promoting melanin in the pituitary gland will increase, which in turn promotes the synthesis of melanin.
Not only that, because the patient's liver function has been damaged, the estrogen secreted by the adrenal glands, ovaries and other organs cannot be inactivated in the liver, resulting in a large amount of estrogen accumulation in the blood.
At the same time, the amount of tyrosinase in the skin will also increase significantly, prompting tyrosine to be further converted into melanin. Estrogen, on the other hand, has a carrying effect, which can promote the deposition of melanin in areas of the body with weak skin cover and less fat accumulation, resulting in changes in the patient's facial skin color.
Usually, as liver disease gradually improves and liver function improves, the face of liver disease will gradually reduce or even disappear completely.
The point that needs to be emphasized here is that the appearance of liver disease is not only a factor of liver disease, there are relevant data surveys showing that kidney disease, endocrine disease, or the emergence of other diseases that lead to a decrease in blood oxygen content in the body, such as chronic lung disease, heart disease, etc., may also cause performance similar to liver disease face.
Therefore, just because you see someone with an abnormal face, you can't suspect liver disease.
Liver disease can only be seen as a signal of physical abnormalities, and if you want to know what is wrong, you should combine other clinical manifestations and related examinations to make a comprehensive diagnosis.
However, if there is a chronic liver disease, such as viral hepatitis, alcoholic liver disease, etc., and there is a sudden abnormal blackness in the face recently, this may be a serious manifestation of the condition, and it is also necessary to seek medical examination in time.