More and more young people with high uric acid.
Backstage, someone always asks Cloves: Obviously do not eat seafood, do not eat meat, but also quit drinking, uric acid is always high.
Frankly speaking, from the results of existing studies, a large part of the high uric acid is caused by congenital genetic factors.
However, the day after tomorrow through diet, weight loss, exercise, etc., can also help you play the "card" given by your parents to a certain extent.
When it comes to diet, it's right to eat less seafood and drink less beer, but many people are likely to overlook another important detail:
Sugary drinks!
The European Anti-Rheumatic Union (EULAR) Recommendations for the Management of Gout (2016) has actually three "eat less" dietary recommendations for gout and hyperuricemia, in addition to the well-known alcohol and high purine foods, and one is sugar-sweetened drinks.
Sugary drinks are also familiar cola milk tea fruity tea.
However, perhaps everyone will be curious about the sugary drink obviously does not have purines, why does it increase uric acid? This starts with one of the most common misunderstandings.
Uric acid is not only related to the purines eaten
Uric acid is a metabolite produced by the body after processing purines.
What determines the amount of uric acid in the blood is the process of "synthesis-excretion" of uric acid in our body.
In a healthy person's body, the liver will process useless purines into uric acid, and then excrete uric acid through the kidneys and intestines, and the whole smooth process is within a stable range.
Image credit: Author & Dr. Lilac Design Team
But once something goes wrong here, uric acid can be elevated. In simple terms, either there are more piles of raw material purines, or less uric acid is excreted.
The problem of less discharge is more affected by genetic factors. That is to say, the ability of some people's bodies to process uric acid in the blood is inherently worse than others, and some people can even only alleviate it through drugs.
Part of the problem of too many raw materials is related to diet, which is why people with gout and hyperuricemia are recommended to control purine intake.
But another major source of purine, which many people do not know, is the purine we produce ourselves, also known as endogenous synthetic purines.
That is, even if you don't eat anything, the body's own metabolism produces purines.
The terrible thing is that some foods are very "hearty", although they do not contain purines, but some of the ingredients contained in them can promote the body to synthesize more purines, resulting in elevated uric acid.
Sugary drinks are typical of this.
Many patients with high uric acid are unaware of the harm of sugary drinks, and may even feel that replacing wine with drinks is a "healthy" dietary choice, which is really not worth the loss.
Sugary drinks may also increase the risk of gout
Sugary drinks are not just as simple as increasing the amount of purines in the body to raise uric acid, and some studies have confirmed that people with higher intake of sugary drinks, even if they did not have gout, have a higher chance of subsequent gout.
Two studies by Harvard scientists published in the top journals of medicine, BMJ and JAMA, followed 46,393 men and 78,906 women for more than a decade or two, and came to 5 worth sharing conclusions:
Men who drank an average of 1 serving of a sugary drink (about 250 to 300 ml, less than a cola) a day had an average 44% increased rate of new gout compared to those who did not drink it at all;
Women drink 1 sugary drink a day, and the new onset of gout is twice as high as that of men;
On this basis, if the sugary drink is drunk more, the degree of increased risk is also higher;
Even if sugary drinks are replaced with pure juices that do not contain sugar, the risk will still increase, and even the role of increasing the risk may be greater than that of sugary drinks;
Sugar-free beverages that do not contain artificial sweeteners do not increase the risk.
Image source: Figureworm Creative
That is to say, sugary drinks may not only make uric acid unable to come down, but may also further induce gout, and pure juice also needs to be vigilant.
Fructose, which may be the culprit in elevating uric acid
Why is a small bottle of sugary drinks so harmful? From the known studies, it may be that the fructose in it is doing things.
Fructose is a special presence among all sugars.
When the liver processes all other sugars, it has various mechanisms to regulate the speed at which it is processed, ensuring that things are done without hurrying and methodically.
Only when dealing with fructose, it is the kind of madness that is slammed on the accelerator and not equipped with brakes as soon as it comes up. This process of crazy processing will eventually promote the production of more purines.
The liver will also continue to use these accumulated purines to synthesize uric acid, and the direct result is to cause the blood uric acid to rise.
Moreover, studies have also found that the molecular structure of fructose is similar to uric acid, which may cause the kidneys to reduce their ability to excrete uric acid. This "two-pronged" effect makes it difficult to think of uric acid.
The process by which fructose is metabolized in the body
(It doesn't matter if you don't understand!) The point is that more purines will be induced)
Image source: References
Karolinska Institutet did a human study, and part of it was getting healthy people to drink drinks with the same calories but different fructose content.
The results showed that subjects who drank the most fructose drinks had an average 15% increase in blood uric acid levels after drinking 35 grams of fructose compared to before drinking.
And 35 grams of fructose is just the amount of fructose contained in a bottle of 600 ml cola.
Almost every sugary drink contains fructose
The name "fructose" may be unfamiliar to everyone, but in fact, most sugary drinks in life contain fructose.
If you occasionally look at the ingredient list of beverages, what are the most common ingredients in the ingredient lists of sugary drinks?
Sugar? rock candy? honey? cane sugar? Fructose syrup?