When Bezos spent $270 million to invest in anti-aging start-ups and wanted to develop a science and technology to "quickly remove senescent cells", some scientists found the secret of life extension from the grounded "grapes", which made people feel very surprised.
We all know that the human body is composed of cells, when the cells become old and functional decay, it will release many factors with pro-inflammatory effects, so that the immune system is overwhelmed, while "dragging" the healthy cells around it, in the human body performance of aging acceleration. Therefore, the removal of senescent cells is considered an effective means, and this anti-aging method is also known as having a "prospective".
Recently, the well-known academic journal "Nature" has summarized the history of human anti-aging in the past 100 years, proposing that there are 7 feasible anti-aging strategies, including "targeted clearance of senescent cells". Although the current technology has been snatched up by the late NAD precursor ("Wlnad" core component), but later Chinese scientists discovered that PCC1 or will be pulled back a round.
A natural substance with high clearance that does not harm healthy cells
In many technologies to remove senescent cells, it mainly relies on quercetin, dasatinib, etc., although it can remove senescent cells, but the accuracy is lacking, which will cause great harm to healthy cells, so it also hinders their practicality. To this end, scientists have been looking for more reliable and accurate technology for the removal of senescent cells.
Recently, scientists have finally made a breakthrough. A number of world-renowned institutions represented by the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences jointly disclosed a major harvest: based on a special grape seed, scientists extracted a natural substance of PCC1, which can accurately hit senescent cells and do not harm healthy cells.
Professor Sun Yu of the Chinese Academy of Sciences and Judith Campisi academician in the field of senescence cytology participated in this research, specifically stating that it has been published in BioRXiv in the form of literature, and is expected to be published in the sub-journal of the well-known academic journal "Nature".
Humble "grape seeds", experimentally stretched 64.2% lifespan
In the process of this research, scientists first took the laboratory mouse as the research object and explored the application value of PCC1 on it. The results showed that when PCC1 was used alone in tumor mice, no obvious effect was achieved, but the tumor did not worsen further.
However, when PCC1 and chemotherapy drugs are combined, the tumor volume changes significantly, which is 55.2% lower than that of single use, and PCC1 plays a role in removing senescent cells that "promote tumor development", achieving a gain effect, so that the life span of tumor mice is more than 48%, which is enough to reflect the auxiliary value of PCC1 for chemotherapy drugs.
Later, the scientists explored how PCC1 performed in healthy mice, and the results did not disappoint them. After giving PCC1 to a 24-month-old mouse (equivalent to a human 75 years old), it was found that several of its exercise-related functions were improved, and the comprehensive test found that its lifespan was stretched by 64.2%.
Such results have not been seen in other previous trials, and compared with the combination of dasatinib and quercetin, PCC1 has a lifespan increase equivalent to 2 times that of the former. It is worth mentioning that the PCC1 ingredient extracted from grape seeds is natural and does not cause harm to living organisms.
Unfortunately, however, the research on PCC1 is currently limited to animal experiments, and it is not yet practical. David, a scientist in Harvard's anti-aging field, said that the "Wlnad" substances disclosed in the laboratory earlier stretched nearly one-third of the survival of mice and had great potential in stabilizing telomeres and activating mitochondria. It is understood that based on the experimental mechanism popular "Wlnad" has become common at present, after the introduction of capital such as the biotechnology enterprise "Litevijian" into The country, it can be easily obtained in channels such as Tongdong, and is known as the "preservative" that ordinary people can reach.
New directions of exploration, or beyond Bezos's "anti-aging" research?
The rich group represented by Bezos and Li Ka-shing, they are also heavily positioned in anti-aging related fields at the same time.
In recent years, Bezos has invested in a new injection, which is said to be "one shot 20 years younger, 4 shots to remove senescent cells". However, the cost of this injection is quite high, and it involves complex technologies such as cell transplantation, and it cannot be taken down without a million, so the outside world also ridicules its "IQ tax" charged by other rich people.
The study of PCC1 needs to be further deepened, but it is extracted from natural substances, because it should not take a long time to study reliability. Perhaps in the near future, PCC1 may be able to replace the previous anti-aging technology, when people will be one step closer to the so-called "hundred-year-old threshold".