Immortality has always been the pursuit of mankind, Qin Shi Huang poured his strength into finding the Elixir of the East Sea, and Newton spent 30 years studying alchemy in his later years, which ultimately ended in failure. But with the development of science and the improvement of medical standards, the average life expectancy of human beings is increasing, from thirty or forty years old in ancient times to seventy or eighty years old today, and some people can even live to more than 100 years old. Some of the breakthroughs in cutting-edge technology may make us take another step forward in the pursuit of eternal life.
Modern version of "immortality": senescent cell removal method
According to the understanding of modern biology, the essence of aging is the aging of cells. Senescent cells are also called "zombie cells" because they behave similarly to "zombies" in many ways, neither being able to divide nor perform normal physiological functions. More importantly, senescent cells also release a mixture called "SASP", which not only defends itself from being eliminated, but also induces the normal cells around it to age, which is extremely abominable.
Therefore, the most direct and effective means of delaying aging is to eliminate senescent cells. In 2015, Professor James Kirkland first discovered the substances that scatinib and quercetin (D+Q) that scavenged senescent cells, and called such substances that scavenged senescent cells Senolytics. In the years that followed, more than a dozen Senolytics materials were discovered.
The discovery of the Senolytics substance is a huge step forward in the field of aging and has great significance for human beings, so this technology was selected as one of the "Top Ten Breakthrough Technologies in the World" by MIT Science and Technology Review in 2020.
However, dasatinib and quercetin have a relatively large defect, that is, they are more toxic, which will not only remove some senescent cells, but also affect normal cells. In order to find more efficient and safer Senolytics substances, scientists can be said to have worked hard.
Ginger is on fire? American scientists extract longevity substances from it
Recently, the National Institute of Aging (NIA) published an article in the authoritative journal "PLOS ONE" that they found that two compounds in ginger extract, 6-curculinol and gingerenone A, have the property of scavenging senescent cells.
The researchers compared the two "rookies" of 6-gingerol and gingerenone A with the "old combination" of dasartinib + quercetin (D+Q) and found that after 48 hours of treatment, D+Q not only cleared about 40% of senescent cells, but also inhibited the proliferation of normal cells, and there was a certain cytotoxicity; while 6-gingerenophenol, although less toxic, promoted the proliferation of normal cells, but its effect of clearing senescent cells was not good, not as good as D+Q.
Gingerone A combines the advantages of the two, not only the effect of removing senescent cells is excellent, exceeding D + Q, but also the safety is also very good, and has almost no effect on normal cell proliferation. Therefore, the National Institute on Aging (NIA) believes that gingerenone A has great potential to become a new generation of Senolytics substances, and it seems that ginger is about to catch fire again!
It doesn't matter if you don't eat ginger, there is more than one means of anti-aging
Delaying aging is not only a means of removing senescent cells, but also allowing cells to "eat" harmful garbage themselves is also an effective method, which scientists call autophagy. Light fasting can be a good way to promote autophagy, delay aging, Paipai for everyone to prepare a light fasting practice guide. Due to the length of the article, the specific recipes will not be repeated, you can find a small assistant: timepie10, the keyword "QE recipes".
With the rapid development of modern biomedicine, we have more and more anti-aging "weapons", and aging seems to become less terrible. Linda Gratton, a professor of management at the London Business School, said: "This is an era of longevity, people born in the early 21st century have half the probability of living to 100 years old, it seems that we are really not far from the century-old era." Time School brings together a variety of cutting-edge anti-aging information, welcome attention, and witness the arrival of this era with us.
—— TIMEPIE ——