Chromosomal balance translocation is the most common chromosomal structural variation in humans, and the likelihood of such patients becoming pregnant naturally and having a healthy baby is very low, and most of them will lead to infertility, repeated miscarriages, fetal cessation or birth defects due to chromosomal abnormalities. So, can chromosomal balance translocation do IVF?
AA69 Fertility Center said: Patients with chromosomal balance translocation generally have no symptoms, and most patients are found after examination because of repeated miscarriages during childbirth, childbirth deformities or mentally retarded children. A large part of the chromosomal balance translocation is inherited by one parent, and a small part is spontaneous variation. There are currently no drugs that can treat and cannot repair abnormalities in other ways.
In order to ensure the health of the offspring and truly achieve eugenics, it is recommended that patients with chromosomal balance translocations use IVF technology to assist in pregnancy, test the embryos, screen out normal embryos, and achieve fertility.
IVF techniques are divided into three types, of which the third generation of IVF technology, namely PGT technology, genetics detection of chromosomal structure variation before embryo implantation, selection of chromosome copy number normal embryo transfer, to help chromosomal translocation carriers successfully have children.
So, can choosing a third-generation IVF fertility guarantee that the baby born is completely healthy?
First of all, the third generation of test tubes is performed for embryo screening, not change. And mainly for a specific genetic problem of the patient for screening, such as chromosomal balance translocation carriers, for chromosomal diseases, can not exclude single gene diseases, polygenic diseases and other genetic factors caused by diseases.
Of course, the third generation of IVF cannot exclude fetal abnormalities caused by non-genetic factors, such as fetal malformations caused by intrauterine infections, radioactive substances, and drug poisons. Current data suggest that the incidence of third-generation IVF malformations is similar to that of natural pregnancies in chromosomally normal populations. Therefore, even if the third generation of IVF is successful, regular obstetric check-ups are still required during pregnancy, and prenatal diagnosis is performed according to the doctor's recommendation.