There are many types of aspirin, how to take the least side effects? Should aspirin be eaten in the morning or at night? Different dosage forms of drugs have different peak times, in order to better inhibit the aggregation of platelets, when is it better to eat aspirin?

Author: Guangdong Pharmaceutical Association Dongguan People's Hospital Yang Hao

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Aspirin, which has antipyretic and analgesic, anti-inflammatory, anti-rheumatic, anticoagulant effects. In the clinic, the most commonly used role of aspirin is anticoagulant, which inhibits the aggregation of platelets and can be used to prevent transient ischemic attacks, myocardial infarction, prosthetic heart valves and venous fistulas, or the formation of thrombosis after other surgeries.

Aspirin is divided into aspirin common dosage forms and aspirin enteric-coated tablets, the difference between the two is mainly that the aspirin enteric-coated tablets are wrapped in a layer of enteric coating that can resist the acidic environment in the stomach.

■ Aspirin common dosage form is recommended after meals because of gastrointestinal reactions.

■ Aspirin enteric-coated tablets have acid resistance, reduce the damage of the drug to the gastric mucosa, it is recommended to take it before meals.

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For patients with hypertension, taking aspirin at night before going to bed can be more effective in resisting platelet hyperfunction in hypertensive patients, controlling blood pressure, regulating platelet function, and reducing blood viscosity.

The peak time for platelet aggregation is in the morning, and the peak of cardiovascular and cerebrovascular accidents is from 6 to 12 o'clock in the morning.

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<col>

pharmaceuticals

Peak time (h)

Time to take the drug

Aspirin enteric-coated tablets

0.167-0.333

Wake up in the morning

Aspirin enteric-coated capsules

44262

At night before bedtime

Aspirin intestinal effervescent tablets

1/2/21

Aspirin dispersible tablets

01

Aspirin tablets

02

Aspirin extended-release tablets

Aspirin enteric-coated extended-release tablets

7.3

Evidence-based guidelines for antithrombolytic and thrombolytic therapy of the American College of Chest Physicians (ACCP) state that the use of aspirin to prevent myocardial infarction, stroke and vascular death is best taken in the morning, with aspirin enteric-coated tablets preferred.

During the medication, you should pay close attention to the physical condition, such as finding that the skin has ecchymosis, bleeding gums, nasal bleeding, melena, hematuria, etc., to stop the drug in time and go to the hospital for treatment.

Review expert: Guangdong Pharmaceutical Association Dongguan People's Hospital Liang Shuzhen

The above is the original work of the volunteers of the "Drug Safety Cooperation Alliance", if you reprint, please indicate the author and source!

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