Uric acid, most of which comes from the normal metabolism of cells, the remaining part comes from the food that is usually eaten. Uric acid in the normal human body has been maintained within a fixed range (80 to 360 μmol/L for women, 150 to 420 μmol/L for men).
However, if uric acid is produced too much or the passage of uric acid is not smooth, it can lead to the accumulation of uric acid in the body. Prolonged hyperuric acid exceeding the standard can not only trigger gouty arthritis, but may also lead to severe kidney disease.
Recurrent episodes of acute gout arthritis can quicken the deterioration of the condition, especially joint deformities and tophi, and may also turn into chronic gouty arthritis. To alleviate the pain of drilling in gout attacks, medication analgesia is used as its main therapy.
There are many types of drugs available to gout patients, but some drugs are suitable for different situations and side effects, how to choose drugs?
<h1 class="pgc-h-arrow-right" data-track="9" > colchicine</h1>
Colchicine, also known as colchicine, is an alkaloid extracted from the lily family plant Colchicine. It can fight the inflammation caused by gout, and the mechanism of action is simply:
Block the enzyme that "ventilates the message" to the immune system, inhibits the aggregation of white blood cells in the joint part of gout, weakens the role of white blood cells in engulfing uric acid, and reduces the inflammatory response, so as to achieve the purpose of rapid anti-inflammatory and analgesic.
Whether it is anti-inflammatory pain relief after an acute arthritis attack, or preventing arthritis attacks during remission, colchicine has a very important role.
Applicable:
(1) Gout can start to use colchicine to prevent gout attacks 2 weeks before the treatment of uric acid;
(2) Take it immediately during an acute gout attack, and generally the symptoms can be relieved within 24 to 48 hours.
side effect:
Colchicine itself is very toxic, but it is metabolized in the body into a highly toxic dicolline, with the following side effects:
(1) Abdominal pain, diarrhea, vomiting, loss of appetite and other gastrointestinal discomfort, severe cases can lead to dehydration and electrolyte disorders.
(2) Muscle neuropathy such as muscle weakness and elevated creatine kinase. This side effect is uncommon and occurs in long-term medication users and people with mild renal insufficiency.
(3) Bone marrow suppression: the appearance of thrombocytopenia, neutrophilia, and even aplastic anemia, which can sometimes be life-threatening.
Colchicine is the most common medication against gout, but if colchicine responds largely or is not effective, it needs to be switched to a nonsteroidal analgesic (NSAIDS) or glucocorticoids.
<h1 class="pgc-h-arrow-right" data-track="21" > nonsteroidal anti-inflammatory drugs (NSAIDs</h1>).
The mechanism of action of NSAIDs is to inhibit PG synthase and reduce PG synthesis, thereby exerting anti-inflammatory, antipyretic and analgesic effects. Including phenylbutazone or hydroxybutyclosone, indomethacin, yan anthracym, dipruxen, ibuprofen and so on.
It may be preferred in patients with uncomplicated mild acute gouty arthritis attacks, particularly those who cannot tolerate colchicine.
NSAIDs relieve pain by inhibiting prostaglandin synthesis (prostaglandins play an important role in pain and fever), while inhibiting prostaglandins requires reducing the activity of an enzyme referred to simply as COX. COX-1 can catalyze the production of prostaglandin-like substances, which can protect the gastrointestinal tract and platelets. When COX-1 is suppressed by nonsteroidal anti-inflammatory immune drugs (NSAIDs), it can no longer protect the gastrointestinal tract and platelets, resulting in gastric bleeding, gastric mucosal damage, renal function damage and other side effects.
<h1 class="pgc-h-arrow-right" data-track="28" > glucocorticoids</h1>
It has a powerful anti-inflammatory effect, and its anti-inflammatory mechanism is: (1) by inhibiting the release of arachidonic acid, stabilizing mast cells to reduce the production and activation of inflammatory substances such as prostatic cord, leukotriene, histamine, bradykinin, etc.; (2) stabilizing the lysosomal membrane; (3) inhibiting granulation tissue formation.
The drug is only used when the symptoms of gout are very severe, and it is used when other drugs are ineffective or contraindicated, and cannot be used for a long time.
Can not be used for a long time;
Do not use for people with hypersensitivity to hormones, diabetics, and patients with severe hypertension.
These three types of drugs are the most commonly used drugs in the onset of acute gout, and the side effects are different, and gout patients need to choose according to their actual situation.
For patients with high uric acid that is high in uric acid but do not have gout attacks for the time being, there is another drug choice that has no side effects and can lower uric acid - bogytisin.
<h1 class="pgc-h-arrow-right" data-track="42" > bogoligrin</h1>
Bo glucose can be said not to be a medicine, but a health care product. It is suitable for patients with asymptomatic hyperuricemia, hyperuric acid pain period, acute arthritis attack period, and arthritis population.
Its ingredients are mainly turmeric extract, Indian frankincense, ginger root, celery seed extract, nettle leaf extract, dandelion root extract, horseradish root extract, non-denatured type II collagen, black pepper extract these harmless plant extracts, so it is harmless to the body and has no side effects.
Curcumin has antioxidant and immune modulation effects, celery seed extract has a significant effect of reducing uric acid, UC-II is an indispensable collagen component in joint cartilage, other extracts have anti-inflammatory, analgesic effects, so the combination of these extracts can be used for gout treatment and arthritis treatment.
When acute gout attacks, you have to use painkillers with side effects to alleviate it, but you dare not use it for a long time, so as not to hurt the liver and kidneys. Therefore, the use of safe ingredients, no side effects and no dependence of the health care product Bo Glucosamine, not only can help patients with high uric acid to regulate uric acid in the body, but also can play a role in improving the effect of gout and pain, is a safe and good choice.