Calcium gluconate preparation

How is calcium gluconate prepared? Calcium gluconate is a very important application in the fields of medicine, food, materials and chemicals, so how is calcium gluconate prepared? Kang Jinghui Xiaobian and everyone to talk about how calcium gluconate is prepared.

The crystallization process of calcium gluconate affects the yield, quality, and efficiency of the product.

First, the nature of calcium gluconate

Calcium gluconate is a gluconate organic calcium salt with a hydroxy acid structure, industrial grade calcium gluconate is usually yellowish, and food grade calcium gluconate is generally white crystal.

Calcium gluconate has poor thermal stability, losing crystalline water at 120 °C and decomposing at 201 °C. Calcium gluconate is stable in air, odorless, odorless, and easily soluble in boiling water.

Second, the use of calcium gluconate

Calcium gluconate is widely used, calcium gluconate is a commonly used calcium supplement in medicine, clinically used to treat osteoporosis, skin allergies and other diseases; in the food industry can be used as a calcium nutrient enhancer added in beverages, cereals and their products.

Third, the preparation method of calcium gluconate

Calcium gluconate applications are quite numerous, making the preparation of calcium gluconate become particularly important, the preparation of gluconic acid is a key step in the production of calcium gluconate, the current main production methods are fermentation, homogeneous oxidation, electro-oxidation, heterogeneous oxidation, polyphasic oxidation and so on.

The production of calcium gluconate is mainly divided into four parts:

1) Glucose oxidation to gluconic acid, the methods are electrolytic oxidation, enzyme method, Australian chemical method, metal catalytic synthesis method, fermentation method, etc.;

2) The use of gluconic acid and calcium carbonate neutralization to produce calcium gluconate;

3) Concentrated crystallization of calcium gluconate solution;

4) Solid-liquid separation of calcium gluconate crystalline granules.

Fourth, calcium gluconate cooling crystal preparation process

Solution crystallization refers to the process of polymerization and precipitation of solutes in a solution. The basic condition for the crystallization of the solution is the solution supersaturated, according to the method of the solution to produce a supersaturated state, the solution crystallization can be divided into cooling crystallization, evaporation crystallization (concentrated analysis), dissolution crystallization, reaction crystallization and so on. At present, the traditional crystallization process of calcium gluconate is mainly cooling crystallization.

The cooling crystallization method is to reduce the temperature of the calcium gluconate solution to the temperature of the solution corresponding to the saturation concentration, so that the solution reaches a supersaturated state and precipitates the crystallization, also known as cold analysis crystallization. The process of cooling crystallization method basically does not reduce the quality of the solvent, but reduces the solubility of the solvent by cooling, so that the solution becomes supersaturated.

Since calcium gluconate is a substance whose solubility is positively correlated with temperature, and the solubility decreases significantly with the decrease of temperature, the cooling crystallization method is widely used in calcium gluconate crystallization technology.