Source: Chinese Journal of Osteoporosis, Vol. 30, No. 2, February 2024
Corresponding author: Zhang Mengmeng
Summary
Great progress has been made in the molecular biology research of osteoporosis in the direction of bone metabolism molecular signaling pathways, osteoporosis susceptibility genes, osteoporosis-related proteins, and targeted therapy for osteoporosis. Nuclear factor kappa B receptor activating factor/nuclear factor kappa B receptor activating factor ligand/osteoprotetin (RANK/RANKL/OPG) signaling pathway, nuclear factor kappa B receptor activating factor (NF-κB) signaling pathway, mitogen-activated protein kinase/extracellular regulatory protein kinase (MAPK/ERK) signaling pathway, macrophage colony-stimulating factor (M-CSF) signaling pathway, calcium ion (Ca2+) signaling pathway, tyrosine kinase, protein kinase B (Src, Akt) signaling pathway, protein kinase C (PKC) signaling pathway and other important pathways of bone metabolism, vitamin D receptor (VDR) gene, low-density lipoprotein-related protein 5 (LRP5) gene, methylenetetrahydrofolate reductase (MTHFR) gene, estrogen receptor (ER) gene and other susceptibility genes, apolipoprotein E (Apo E), Klotho protein (Klotho), bone morphogenetic protein (BMP), bone salivary protein (BSP) and other related proteins, It is directly or indirectly involved in the regulation of bone metabolism, and the overlapping effects are interrelated and mutually contributing, and a consensus has been reached in this professional field.
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