ZHANG Shanshan,GONG Jun. Effect analysis of acupuncture combined with estazolam tablets in the treatment of patients with chronic insomnia[J].Chinese Journal of Drug Abuse Prevention and Control,2022,28(10):1387-
[1] Yang Shiyun, Zhang Y, Qiao Jing, et al. In vivo distribution of estazolam in 1 case[J].Journal of Forensic Science,2023,39(02):226-228.)
ZHANG Shanshan,GONG Jun. Effect analysis of acupuncture combined with estazolam tablets in the treatment of patients with chronic insomnia[J].Chinese Journal of Drug Abuse Prevention and Control,2022,28(10):1387.)
Mr. Liu, a 45-year-old from Shenzhen, is an executive of a foreign company. Always pursuing the idea that love to fight will win, Mr. Liu has been successfully promoted from a small staff all the way to leave a place in the company. Of course, Mr. Liu has paid a lot of days and nights to get everything he has today. But as he grew older, Mr. Liu felt more and more powerless, how much ability, how great the responsibility, the pressure of work often overwhelmed Mr. Liu, after a long time, he suffered from insomnia!
Insomnia is a very painful thing, even if Mr. Liu finishes his work on time and lies in bed early to rest, he still can't fall asleep over and over, and sometimes he finally falls asleep, but as long as there is a little movement, Mr. Liu will wake up, and he can no longer sleep, and can only watch the moon turn into the sun. Compared with other people's sleepless nights, Mr. Liu has a sleepless night.
When I woke up the next day, I had big dark circles under my eyes. Mr. Liu's wife mocked him for being a panda. Mr. Liu is always angry and irritable for no reason, and his mental state is very poor, and he is more prone to mistakes at work. These are caused by insomnia, but the harm of insomnia doesn't stop there.
Insomnia can also lead to anxiety and depression, studies have shown that patients with insomnia suffer from anxiety or depression are 9 times and 17 times that of normal people, long-term insomnia will also lead to a decrease in cerebral blood flow, resulting in cerebral hypoxia and ischemia caused by cranial nerve damage, mental trance, lack of concentration, and low memory. Secondly, it can also cause endocrine disorders, delayed or absent menstruation in women, and sexual dysfunction in men. The metabolism slows down, which can easily lead to obesity. Thirdly, it leads to low immune function, which makes it easy to catch colds and even induce cancer.
Every time Mr. Liu's wife saw Mr. Liu sleepless all night, lying on the sofa tired after getting off work during the day, she said distressedly, if you don't take some sleeping pills, your body will not be able to survive like this. But I saw Mr. Liu wave his hand and said, "It's a medicine that is three points poisonous, and taking medicine can only solve it for a while, so I'll try other methods first." In fact, many people have the same psychology as Mr. Liu, worrying about the side effects of sleeping pills, and would rather insomnia than take medicine.
Is this really desirable? If you have mild insomnia, you can do light exercise before going to bed, sweat slightly, listen to music to relax your mind, and drink a glass of milk before bed to help you sleep, etc. If you still have insomnia despite sleep aids, you can try medication to help you sleep.
Mr. Liu also tried a lot of methods but still couldn't sleep, his body deteriorated, and various physical indicators were abnormal, so he couldn't stay up and went to the hospital for treatment. After learning about Mr. Liu's condition, the doctor prescribed estazolam for him and said: "Now the drug addiction is relatively low, so you don't have to worry about getting addicted to sleeping pills, especially if you take it for a short time, you don't have to worry about this problem." ”
Mr. Liu took a pill of estazolam as prescribed by the doctor before going to bed, but he didn't expect his eyelids to fight half an hour later, and he fell asleep. This is also a big advantage of estazolam because it has a strong sleep-inducing effect, and patients tend to fall asleep quickly after taking it. When Mr. Liu woke up the next day, he found that he was full of energy, full of energy, and his work efficiency had been greatly improved, and he was excited to think that he had finally found a solution to the problem of insomnia.
Mr. Liu's sleep was indeed solved, but as time went on, Mr. Liu also found that he became more and more dependent on estazolam, and as long as he did not take medication, his sleep would return to before, and he could not fall asleep for a long time. Such a change made Mr. Liu can't help but wonder if he is addicted to drugs, but he can't sleep without eating. At the same time, one pill before going to bed could not meet his requirements for falling asleep, and he needed to take two pills, so Mr. Liu was worried about such a change, so he planned to take one pill and drink some red wine to promote sleep before going to bed. Under the influence of alcohol and drugs, Mr. Liu gradually fell asleep.
The next day, his wife got up and found that Mr. Liu had not woken up yet, and she was not in a hurry to wake him up, but when she saw that Mr. Liu was still not awake when it was almost time to go to work, she finally felt that something was wrong, because Mr. Liu had a strong sense of time, but found that Mr. Liu's breathing was weak and his face was pale.
If you can't wake up, call 120 immediately.
To Mrs. Liu's disbelief, the doctor's diagnosis was estazolam poisoning. Mrs. Liu hurriedly said that it was impossible: "It's not the first time that Lao Liu has taken estazolam, and there is no problem for so long, besides, how can only one pill cause poisoning?" The doctor helplessly explained: "Mr. Liu has a great smell of alcohol, alcohol will increase the efficacy of estazolam and promote the absorption of the drug, the pharmacological mechanism of estazolam is to inhibit the excitement of the brain, and taking sleeping pills and drinking alcohol produces a double inhibitory effect, which can easily lead to coma." ”
After injecting the estazolam rescue drug naloxone, Mr. Liu finally woke up after 6 hours, only to learn that he had taken a turn in the ghost gate, or because of his own drinking, and regretted: "I just wanted to take one less pill when I drank, but I didn't expect it to be so harmful!" "The doctor reminds that when using estazolam to treat insomnia, these 3 problems are worth paying attention to, and the slightest carelessness will be self-defeating.
First: Patients with respiratory impairment should not take it
The main principle of the effect of stezolam is to inhibit part of the nerve center, so the respiratory center will also be inhibited, if there are patients with respiratory diseases such as chronic obstructive pulmonary disease, respiratory failure patients, under the doctor's knowledge, estazolam should be used with caution.
Second: drug interactions
Interactions between drugs can increase or decrease the effectiveness of drugs, and estazolam is no exception. When combined with antihypertensive drugs, it can increase the antihypertensive effect, so when hypertensive patients need to eat and sleep for insomnia, they need to check their blood pressure, so as not to have low blood pressure during sleep, resulting in a decrease in cerebral blood flow and cerebral infarction.
Because estazolam has the effect of inhibiting brain excitability, when combined with central inhibitors, it can increase the risk of respiratory depression and even cause death. There are many other drugs that can interact with estazolam, so before using estazolam, patients should inform their doctor about the drugs they are taking in time to avoid drug interactions that lead to irreversible things.
Third: It is not recommended for patients with liver and kidney insufficiency
The liver has the ability to detoxify, and after taking estazolam tablets, because the detoxification ability of patients with impaired liver function decreases, resulting in some estazolam not being decomposed, and the blood drug content increases, resulting in a prolonged half-life of estazolam and a prolonged drug effect. At the same time, because estazolam has the effect of inhibiting brain excitability, patients with liver failure are prone to hepatic encephalopathy if they take estazolam, so they must strictly control the dosage or even prohibit taking it under the advice of doctors.
And the kidneys have the ability to detoxify. Patients with renal insufficiency will have a decrease in the excretion of toxins from the body due to the decline of kidney function, and if you take estazolam for a long time, it will lead to a further increase in toxins in the body, and it will also increase the burden on the kidneys, further leading to a decline in kidney function.
(Note: "Review of estazolam is a good medicine for insomnia, can it be taken for a long time?") Is it important to know these 3 points? >> Some of the pictures are network diagrams; Reprinting and plagiarism are prohibited in the article)
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