Thrombocytopenia is the main clinical manifestation or common complication of a variety of diseases, often need to increase the number of platelets through drugs, in order to achieve the purpose of preventing bleeding and hemostasis, caffeic acid tablets are platelet-raising oral drugs, and at the same time have the triple effect of platelet-raising, leukocyte-raising, hemostasis, which departments and diseases can be used for?
1. Indications
It is used to prevent bleeding or stop bleeding during surgery, as well as hemostasis for bleeding disorders such as internal medicine and obstetrics and gynecology, and is also used for leukopenia and thrombocytopenia caused by various reasons.
2. Dosage
Oral, 0.1 g to 0.3 g (1 to 3 tablets) three times a day for 14 days, and can be used for several consecutive courses.
3. What conditions are available in clinical practice?
gynecology
1. Stop bleeding
1. Excessive menstrual flow manifested by abnormal uterine bleeding: on the basis of conventional treatment, combined with caffeic acid tablets or caffeic acid tablets alone for treatment, oral, 3 tablets at a time, 3 times a day, and the course of treatment is adjusted according to the bleeding situation.
2. For irregular vaginal bleeding caused by cervical lesions, vaginal diseases and other reasons: add caffeic acid tablets on the basis of conventional treatment, 3 tablets at a time, 3 times a day, and adjust the medication time according to the degree of bleeding reduction.
3. Postoperative bleeding after abortion: Caffeic acid tablets can be used for adjuvant treatment, 3 tablets at a time, 3 times a day, for 6 days.
4. Bleeding after uterine curettage and hysteroscopic surgery: Caffeic acid tablets can be used for adjuvant treatment, 3 tablets at a time, 3 times a day, taken for 5-7 days, and the course of treatment can be adjusted according to the bleeding situation.
2. Platelet and leukocyte elevation
Gynecological tumors, such as cervical cancer, ovarian cancer, endometrial cancer, etc.: Patients with chemoradiotherapy can prevent or treat leukopenia and thrombocytopenia caused by chemoradiotherapy.
Department of Infectious Diseases
1. Liver disease
1. Thrombocytopenia and leukopenia caused by hypersplenism in patients with liver cirrhosis: oral caffeic acid tablets at the same time as conventional treatment, 3 tablets at a time, 3 times a day, the general medication time is 2 weeks to 3 months, and the medication time can be adjusted according to the patient's blood cell recovery.
2. Symptoms such as gingival bleeding, nosebleeds, purpura and other symptoms caused by decompensated liver function in the decompensated stage of liver cirrhosis, as well as gastrointestinal bleeding and hematochezia caused by portal hypertension or complications: oral caffeic acid tablets at the same time as conventional treatment, 3 tablets at a time, 3 times a day, and adjust the medication time according to the reduction of bleeding.
3. Thrombocytopenia and leukopenia caused by myelosuppression caused by hepatitis B and hepatitis C virus, as well as thrombocytopenia and leukopenia caused by the use of interferon in the treatment of hepatitis: oral caffeic acid tablets at the same time as conventional treatment, 3 tablets at a time, 3 times a day, take for at least 2 weeks, and adjust the medication time according to the degree of platelet leukocyte recovery.
2. Tuberculosis
1. Adverse reactions or toxic reactions of the blood system caused by taking anti-tuberculosis drugs for tuberculosis, such as leukopenia, thrombocytopenia and bleeding manifestations: oral caffeic acid tablets, 3 tablets at a time, 3 times a day, 14 days for a course of treatment, can be used for several courses of treatment.
2. Symptoms of hemoptysis in patients with pulmonary tuberculosis: oral caffeic acid tablets, 3 tablets at a time, and adjust the medication time according to the reduction of blood loss.
Proctology
1. Stop bleeding
1. Symptoms of hematochezia caused by common anorectal diseases such as anal diseases, colon diseases, rectal diseases, and Crohn's disease: on the basis of treating the original disease, add 2-3 caffeic acid tablets once, 3 times a day, for 5-8 days, or adjust the dosage according to the condition.
2. Prevention or treatment of bleeding symptoms after surgery for common diseases in proctology: 2-3 tablets at a time, 3 times a day, for 5-8 days, or adjust the dosage according to the condition.
2. Platelet and leukocyte elevation
Anorectal tumors (rectal cancer, colon cancer, etc.) leukopenia and thrombocytopenia caused by chemotherapy drugs.
Hematology
1. Immune thrombocytopenia (ITP): combined with hormone therapy or oral caffeic acid tablets alone, 3 tablets at a time, 3 times a day, a course of treatment for one month, and the medication time is adjusted according to the patient's condition.
2. Aplastic anemia: on the basis of the treatment of hormones and immunosuppressants, add caffeic acid tablets, 3 tablets at a time, 3 times a day, take 3 months as a course of treatment, adjust the course of medication according to the patient's condition, and can be used for several courses in a row.
3. Chronic myeloid leukemia treated with imatinib, acute myeloid leukemia induction chemotherapy, non-Hodgkin lymphoma systemic chemotherapy or local radiotherapy: caused by myelosuppression of leukopenia and thrombocytopenia, 3 tablets at a time, 3 times a day.
4. Various bleeding symptoms: various bleeding symptoms caused by common hematological diseases such as ITP, aplasia, leukemia, etc., such as skin purpura, nosebleed, gum bleeding, gastrointestinal bleeding, respiratory tract bleeding, menorrhagia, etc. Oral caffeic acid tablets, 3 tablets at a time, 3 times a day, adjust the time of administration according to the reduction of bleeding.
5. Thrombocytopenia and leukopenia of various unknown causes: oral caffeic acid tablets, 3 tablets at a time, 3 times a day. Adjust the timing of the drug according to the recovery of blood cells.
Oncology
1. Prevention of granulocytopenia and thrombocytopenia by radiotherapy and chemotherapy for multisystem tumors: oral caffeic acid tablets 3 days before or at the same time during chemotherapy and radiotherapy, 2-3 tablets at a time, 3 times a day, and the medication time is adjusted according to the patient's condition.
2. Myelosuppression caused by radiotherapy and chemotherapy for multi-system tumors: granulocytopenia caused by grade I and grade II myelosuppression, moderate to mild thrombocytopenia, 3 tablets at a time, 3 times a day, the course of medication is adjusted according to the patient's condition, and several courses of treatment can be used continuously.
3. Cytopenias of various causes: oral caffeic acid tablets, 3 tablets at a time, 3 times a day.
Endocrinology
1. Symptoms of leukopenia and thrombocytopenia caused by hyperthyroidism: oral caffeic acid tablets 3 tablets at a time, 3 times a day. 2 weeks is a course of treatment, and the course of medication can be decided according to the patient's blood recovery.
2. Prevention or treatment of granulocytopenia and leukopenia caused by the use of antithyroid drugs in patients with hyperthyroidism: oral caffeic acid tablets 1~3 tablets once, 3 times a day. 2 weeks is a course of treatment, and the course of medication can be decided according to the patient's blood recovery.
Other Departments
Department of Rheumatology and Immunology: leukopenia and/or thrombocytopenia caused by systemic lupus erythematosus, rheumatoid arthritis, etc., and leukopenia and thrombocytopenia caused by drugs (immunosuppressants) during treatment
Nephrology: occult blood symptoms and proteinuria caused by nephritis, hematuria caused by glomerulonephritis, stones, and tumors, heparin-induced thrombocytopenia in dialysis patients, and bleeding symptoms caused by anticoagulant drugs during dialysis, such as ecchymosis, bleeding gums, nosebleeds, bleeding at venipuncture sites, and bleeding from the digestive tract and abdominal organs
ENT: bleeding from the oral mucosa, bleeding from the gums, bleeding from the ear, and bleeding from various surgical procedures in ENT
4. Adverse reactions
1. Gastrointestinal diseases: Occasional dry mouth, epigastric discomfort, nausea, abdominal pain, mild diarrhea, etc.
2. Hepatobiliary disease reaction: occasional transient mild increase in alanine aminotransferase.
3. Skin reactions: occasional rash, itching, sweating, etc.
4. Neuropsychiatric diseases: a small number of patients have dizziness, headache, insomnia, etc.
5. Who should use with caution?
1. Patients with gastrointestinal disorders
This product has a carboxyl group in its chemical structure, which is an acidic drug, which may affect the secretion of gastric acid and cause discomfort to patients with peptic ulcers.
2. Patients with liver insufficiency should use with caution
Some patients have a slight increase in alanine aminotransferase after taking the drug, so patients with liver dysfunction should use it with caution.
3. Breastfeeding Period Female Restraint
Caffeic acid is widely distributed in the organs, which can be distributed quickly and selectively similar to estrogen, and may have a certain amount of distribution in the mammary gland, which may be excreted with milk, which may affect the safety of breastfeeding
6. Who should not use it?
1. It is forbidden for patients with hypercoagulable blood system
2. Pregnant women are not allowed
Reviewer: Yang Yuanrong, Chief Pharmacist, Department of Pharmacy, Jingzhou Central Hospital, and Xiong Jianqun, Deputy Chief Pharmacist
Author: Liu Kaifei, chief pharmacist, Department of Pharmacy, Jingzhou Central Hospital