Aspirin is the first choice drug for the treatment of cardiovascular and cerebrovascular diseases, the effect is very significant, with the title of "miracle medicine", deeply loved by middle-aged and elderly patients, whether there is a disease to eat a few pills.
But blind medication can definitely have side effects. Yesterday, the hospital's emergency department received such a patient, 63-year-old Uncle Zhang caused a stomach ulcer because of blind aspirin.
It is understood that Uncle Zhang's health has not been very good, he has a history of hypertension for more than ten years, and he was found to have heart disease a year ago, and he is very worried about his physical condition.
Later, I heard that aspirin has the effect of preventing cardiovascular and cerebrovascular diseases, and immediately found someone to prescribe a little. After a month of medication, Uncle Zhang's stomach began to feel uncomfortable, and he didn't pay attention to it at first, but the stomach pain became more and more severe. After going to the hospital for examination, he was diagnosed with a stomach ulcer caused by excessive aspirin use.
After popular science, Uncle Zhang knew that aspirin could not be taken casually, and it could only be taken under professional guidance. So how exactly should aspirin be eaten?
First, the role of aspirin
1. Antipyretic effect
Aspirin has antipyretic and analgesic effect, mainly by inhibiting the production of prostaglandins in the hypothalamus of the thermoregulatory center to play an antipyretic effect, when the body temperature rises, aspirin can reduce the elevated temperature, widely used in various causes of fever.
Headache, toothache, muscle pain, and toothache. However, it only has the effect of relieving symptoms and cannot completely treat the cause.
2. Analgesic effect
Aspirin is especially effective for pain caused by tissue damage, reducing sensitivity to pain by inhibiting the synthesis of the pain-causing substance prostaglandins. It is also possible to enter the lipid bilayer to block the conduction of pain signals to reduce the sensation of pain. It has a good analgesic effect on clinically common chronic dull pain.
3. Anti-inflammatory effect
The anti-inflammatory and anti-rheumatic effect is strong, and its mechanism of action is to inhibit the synthesis of cyclooxygenase and prostaglandins in the body to reduce their sensitization to blood vessels and cells, and eliminate inflammation by reducing vasodilation and tissues. Acute rheumatic fever can be reduced 24~48 hours after medication, significantly reducing pain and swelling in the joints, and has a significant effect on arthritis diseases.
4. Antithrombotic effect
Aspirin has an antiplatelet aggregation effect, which can prolong blood clotting and bleeding time, and prevent rapid blood clotting to form blood clots.
5. Prevention of cardiovascular and cerebrovascular diseases
Aspirin can reduce the risk of cardiovascular and cerebrovascular diseases, because aspirin has a strong antithrombotic effect, and can also reduce the inflammation of blood vessels. The main cause of cardiovascular and cerebrovascular diseases is the blockage of blood vessels caused by the formation of thrombus, so aspirin can eliminate and prevent thrombosis well to reduce the risk of morbidity.
These effects of aspirin make it the most common drug in clinical treatment and is widely used in the treatment of various diseases.
2. Three drugs that cannot be taken with aspirin
In hospitals, "paying attention to contraindications to drug matching" is a top priority for medical staff. Aspirin interacting with some medications can aggravate the disease and even be life-threatening. The following three drugs taken at the same time as aspirin may work like poison!
1. Anticoagulants
Aspirin in combination with other oral anticoagulants significantly increases the risk of major bleeding, especially heparin and warfarin, which more than double the chance of bleeding.
This is because aspirin and anticoagulant drugs have antithrombotic effects, and the combination will enhance the efficacy, which will lead to platelet dysfunction, further disorder of coagulation mechanism, and worsening of the disease.
2. Hypoglycemic drugs
Aspirin has a hypoglycemic effect, and taking it at the same time as hypoglycemic drugs will strengthen the effect of insulin, so that glycogen catabolism is accelerated, resulting in excessive hypoglycemic effect, and there is a risk of causing hypoglycemia. Therefore, aspirin should be used with caution in patients with both diabetes and heart disease.
3. Anti-gout medications
Aspirin can reduce the uricic acid effect of anti-gout drugs, so that uric acid is retained in the body in large quantities, resulting in hyperuricemia and aggravating gout symptoms.
The above three drugs can not be taken at the same time as aspirin, if your own disease requires that you must take such drugs, you must take the drug under the professional guidance of a doctor, adjust the dose, time and order of medication.
3. Adverse reactions and prevention methods of aspirin
1. Gastrointestinal bleeding
Among them, gastrointestinal reactions are the most common, taking a large amount may cause gastrointestinal mucosal damage to form gastric ulcers, long-term stimulation of gastric ulcers will also cause gastric bleeding or gastrointestinal bleeding, endangering the life of patients. Therefore, aspirin is contraindicated in patients with gastrointestinal disorders.
Aspirin enteric-coated tablets are usually used in clinical treatment to reduce gastrointestinal irritation, and taking drugs on an empty stomach will also reduce irritation to the gastrointestinal mucosa.
2. Allergic reactions
After taking aspirin allergy patients, the immune substances in the body will release a large amount of inflammatory substances, causing the dilation of capillaries, respiratory muscle spasm and other phenomena, resulting in acute urticaria, bronchospasm and aspirin asthma and other symptoms.
3. Salicylic acid poisoning
Aspirin belongs to the salicylic acid class of drugs, long-term use may cause poisoning, dizziness, tinnitus, nausea and other phenomena. Moreover, patients with rheumatic diseases will have a higher chance of poisoning, and severe mental disorders may occur. Therefore, in the process of taking the drug, you must pay attention to the dosage, not too much and not too little.
4. Precautions for taking aspirin
1. Take the medicine at a fixed time every day to avoid missing doses
A single dose of aspirin will have an antithrombotic effect, and occasionally a missed dose will not have a large impact on the treatment effect, but the risk of blood clots will also increase after the number of missed doses increases. Therefore, it is best to take the medicine regularly and quantitatively every day.
2. Do not drink alcohol while taking medication
Do not drink alcohol while taking aspirin, because drinking alcohol while taking the drug can increase the damage to the gastric mucosa and liver. In addition, aspirin can inhibit the rate of alcohol metabolism, allowing alcohol to accumulate in the body, leading to alcoholism.
3. Long-term medication should regularly check hematocrit, liver function and serum salicylic acid content
Long-term use of aspirin may cause salicylate poisoning, so regularly check the content of salicylic acid in the body and adjust the dosage in time.
4. Long-term aspirin use should be carried out under the guidance of a doctor
Summary: Therefore, when we take aspirin, we must use drugs rationally under the guidance of doctors, and we must take them in the right way and choose the type of drug that suits us. Pay attention to the contraindications and adverse reactions of drugs, reduce the harm of drugs to the body, cure diseases while protecting your health.
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