Anti-ischemia, heart protection, heart stabilization rate, treatment of myocardial ischemia, introduction of 3 kinds of Western medicines, 3 kinds of proprietary Chinese medicines
Amlodipine is a clinically commonly used first-line antihypertensive drug, belongs to the dihydropyridine calcium channel blocker, mainly by blocking vascular smooth muscle and calcium ions outside cardiomyocytes through calcium channels into the cell, and the effect on vascular smooth muscle is greater, dilating peripheral arterioles, reducing peripheral resistance, and can reduce renal tubular sodium reabsorption and reduce blood pressure, its antihypertensive effect is stable and long-lasting, antihypertensive intensity and amplitude, small individual differences, no obvious impact on blood sugar and blood lipids, good effect on hypertension in the elderly, It also has a significant antihypertensive effect in alcoholics, and the hypotensive effect is not affected by a high-salt diet, especially in patients with high salt intake and salt-sensitive hypertension in daily habits.
In addition, amlodipine still has an anti-angina effect, and the mechanism of action to relieve angina is not fully defined, but it can alleviate myocardial ischemia by the following ways: (1) dilate the peripheral arterioles, so that the peripheral resistance (afterload) is reduced, thereby reducing myocardial energy consumption and oxygen demand. (2) Dilate coronary arteries and coronary arterioles in normal and ischemic areas, and increase myocardial oxygen supply in patients with coronary spasm (variant angina). Clinically, amlodipine can be used for chronic stable angina or vasospastic angina.
美托洛尔也是治疗高血压的一线药物，属于选择性β1受体阻断剂，主要通过抑制中枢和周围的肾素-血管紧张素-醛固酮系统，降低心肌收缩力、减慢心率而降低血压，其降压作用强而持久，起效快，不仅能降低静息血压，而且能抑制体力应激和运动状态下血压急剧升高，同时还可通过降低 交感神经张力。
此外，美托洛尔还可抑制心脏起搏点电位的肾上腺素能兴奋，降低心肌收缩力，抑制血管平滑肌收缩，降低心肌耗氧量，增加缺血心肌的供氧，改善心肌缺血和心绞痛症状，减少心肌重构，预防儿茶酚胺的心脏毒性作用，减少心血管事件，尤其适用于合并快速心律失常、冠心病、慢性心力衰竭、主动脉夹层、交感神经活性增高和高动力 状态的中青年高血压患者，对老年高血压疗效相对较差。
Isosorbide nitrate is a fast-acting, long-acting nitrate antianginal drug, which acts in the body to metabolize isosorbide mononitrate, and the mechanism of action is the same as that of nitroglycerin, but the action time is longer. Stimulation of guanylate cyclase by releasing nitric oxide (NO) increases cyclosine phosphate (CGMP) and dilates blood vessels. Its role characteristics are as follows: (1) dilate the surrounding arterioles, reduce peripheral resistance and blood pressure, and reduce myocardial oxygen consumption. (2) Dilate the peripheral veins, so that blood is stored in the periphery, reduce the amount of blood returning to the heart, reduce the left ventricular end-diastolic pressure and diastolic coronary blood flow resistance. (3) Dilate the coronary arterioles, redistribute blood flow in the myocardial ischemic area, and relieve angina. Its role in dilating arterial and venous vessels can reduce the pre- and post-cardiac load and be used to fight heart failure.
Xinyue capsules are capsules made by processing total saponins from american ginseng stems and leaves. American ginseng tastes sweet, slightly bitter, cool, beneficial to nourish yin, clear heat and vitality. American ginseng stem and leaf total saponin is a monomer saponin extracted from the stem and leaf of American ginseng, which can replenish qi and nourish yin, and blood.
Modern pharmacological studies have confirmed that Xinyue capsule has the effect of anti-myocardial ischemia, has a protective effect on acute myocardial infarction caused by precorn artery descending branch ligation, can reduce the degree of myocardial ischemia, reduce the scope of ischemia and myocardial infarction area, reduce serum creatine kinase, lactate dehydrogenase and aspartate aminotransferase activities, reduce serum malondialdehyde, improve superoxide dismutase and glutathione peroxidase activities.
Clinically, Xinyue capsules can be used for chest paralysis caused by qi and yin deficiency, chest tightness or heartache, palpitations, shortness of breath, dizziness, fatigue, dry mouth, insomnia, red tongue, fine pulse or knot, coronary heart disease angina see the above symptoms.
Qidong Yixin granules are composed of ginseng, Huang Wu, Mai Dong, Poria, Dihuang, Turtle Shell (hot), Danshen, Tulip, Guizhi, Purple Quartz (calcined), Epimedium, Honeysuckle, Citrus Shell (stir-fried), the whole party plays a beneficial qi nourishing heart, calming the mind and stopping palpitations.
Modern pharmacological studies have confirmed that Qidong Yixin granules have the effect of anti-myocardial ischemia, can reduce coronary resistance, increase coronary flow, reduce myocardial oxygen consumption and oxygen utilization, reduce the area of acute myocardial infarction, reduce the degree of damage to the ultrastructure of myocardial cells, reduce serum creatine kinase, lactate dehydrogenase activity, increase superoxide dismutase and glutathione peroxidase activity, reduce the content of free fatty acids and malonal.
Clinically, Qi Dong Yi heart granules can be used for chest paralysis caused by qi and yin deficiency, heart pulse stasis, chest tightness and shortness of breath, chest pain, palpitations and palpitations, fatigue and fatigue, self-sweating, night sweats, upset, dry mouth, fat and reddish tongue, less moss, pulse weakness or bridging, coronary heart disease angina see the above symptoms.
The analgesic oral liquid is composed of dang ginseng, sanchi, cinnamon, white, amaranth (fried), yanhusuo (vinegar burning), ice flakes, menthol, dilong, and various drugs are combined to play the work of improving qi and invigorating blood and dissolving phlegm.
Modern pharmacological studies have confirmed that oral analgesic solution has the effect of anti-myocardial ischemia, can fight acute myocardial ischemia, has a therapeutic effect on acute myocardial infarction, and can also increase coronary flow of the heart; It has an anti-hypoxia effect and can prolong the survival time of myocardial hypoxia.
Clinically, oral analgesic liquid can be used for chest paralysis caused by insufficient heart qi, blood stasis, sputum obstruction, chest paralysis, chest weakness, chest tightness, heartache, palpitations, shortness of breath, fatigue, coronary heart disease angina see the above symptoms. #心血管健康百问百答 #
