After finding out that they have some signs of pregnancy, female friends are thinking about making sure as soon as possible to see if they are really pregnant. Blood hCG can accurately determine whether you are pregnant or not, and it is also the most accurate test method available.
Therefore, the hcg value has become the most concerned number for sisters after transplantation, and the progesterone value on the report sheet is also confusing, today we will explore the "love and hate" between HCG, progesterone and miscarriage!
What is the normal value of HCG after pregnancy
On day 6 of fertilization, the trophoblast layer of the fertilized egg forms and secretes trace amounts of HCG. When fertilization is on days 7 to 8, HCG can be detected in the blood, and its concentration increases exponentially with increasing weeks of pregnancy. The amount of HCG is directly proportional to the number of trophoblasts, and the secretion volume increases rapidly in the first trimester of pregnancy, increasing by 1 times every 1.7-2 days, reaching a peak at 8 to 10 weeks of pregnancy, and rapidly decreasing to 10% of the peak after 1 to 2 weeks. At the same time, it is necessary to dynamically observe the changes in blood HCG and determine the possibility of threatened miscarriage or ectopic pregnancy.
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What is the normal value of HCG after pregnancy?
The serum HCG value during normal pregnancy is directly related to the number of gestational weeks, and the HCG (IU/L) value varies from gestational week to week, and shows a positive increasing trend.
△ Changes in blood hCG during pregnancy
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Ultrasound is a quick and accurate way to diagnose early pregnancy
Vaginal B ultrasound is visible 5 weeks after the last menstrual period. The original heart canal beat can be shown after 6 weeks, and the embryo can be judged to be alive based on the presence or absence of heart canal beat at 7 weeks' gestation.
When first-trimester ultrasound does not yet determine pregnancy outcomes, blood hCG tests are used to predict pregnancy outcomes. Due to its early rapid exponential growth, then to the platform, and then decline, it is necessary to dynamically monitor blood HCG changes, but it takes more than 48 to 72 hours to draw conclusions.
What is the normal progesterone value after pregnancy?
Progesterone is secreted by trophoblasts and corpus luteum before 8 to 10 weeks of gestation and mainly from the placenta after 8 to 10 weeks. The amount of progesterone is gradually increased throughout pregnancy, slower in the first trimester, accelerated in the second trimester, and peaks at term pregnancy. Serum progesterone is fairly stable during 5 to 12 weeks' gestation and has little to do with gestational age.
Changes in progesterone levels are a reliable measure of whether luteal function and placental development are normal. Because serum levels are stable in the first trimester, continuous monitoring is not required to provide the doctor with an early basis for diagnosis.
Let's take a look at how progesterone values change after pregnancy. For example, the progesterone reference value (ng/mL) at weeks 1-3 is 4.7-50.7, and the progesterone reference value (ng/mL) at weeks 4-6 is 19.4-95.3. Progesterone levels were associated with outcomes in early pregnancy, with serum progesterone levels significantly lower in women with embryonic cessation and ectopic pregnancy than in patients with threatened miscarriage and normal early pregnancy.
With progesterone at 15 to 25 ng/mL, the pregnancy outcome is basically intrauterine pregnancy, but early threatened miscarriage is predisposed. Progesterone is less than 15 ng/mL, and the pregnancy outcome is mostly ectopic pregnancy or residual miscarriage. Progesterone greater than 25 ng/mL, the pregnancy outcome is mostly intrauterine normal pregnancy, some have threatened miscarriage, generally after giving supplemental luteal function, most can continue pregnancy.
Therefore, we believe that there is a high probability of pregnancy failure when progesterone is less than 15 ng/mL. Unfortunately, low progesterone levels do not identify a residual miscarriage or ectopic pregnancy. This requires a combination of vaginal ultrasound to improve diagnostic rates.
The "triangular relationship" of HCG, progesterone, and miscarriage
After the pregnancy is successful, the two data we often see when we go to the hospital to check are progesterone and HCG, and the doctor also attaches great importance to these two data. If there is a poor doubling of HCG or a low progesterone, is it a maternal problem or a fetal problem? The answer is that it's all possible. Both maternal and fetal problems can lead to miscarriage. Let's discuss the relationship between these three.
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The HCG doubles well and the progesterone drops
The HCG doubled well, and progesterone decreased, which means that the embryo is developing normally, but HCG progesterone does not function properly. If this condition is conditional, rest, try to lie down, as long as progesterone is not particularly low, not supplementation can also protect the fetus.
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Progesterone normal HCG doubling is not good
Progesterone is normal, but the doubling of HCG is not good, which is very rare. Because HCG promotes the production of progesterone, HCG is not good, and progesterone is generally not good. Let's specify the following from two scenarios:
Progesterone is normal and the HCG doubling is "relatively" not good. What does it mean, that is, you test one day, the value goes up but not to the multiple, the difference is one hundred and two hundred, that is relatively bad. If your HCG is already tens of thousands, then it is normal to start doubling not so fast, the speed will come down.
Progesterone is normal and the HCG doubling is "absolutely" bad. Absolutely bad, that is, the value is in a range, for example, 8 days, only doubled, this situation is not very good. First of all, to rule out ectopic pregnancy, and then it may be that there is a problem with the embryo, and now many hospitals only supplement progesterone, rarely supplement HCG, because HCG is low, it is very likely that the embryo itself is not good, and the value of fetal preservation is not large.
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Progesterone drop hCG doubled badly
HCG does not double but declines, progesterone is also decreasing, this situation doctor is recommended that you first save the fetus, if there is still no improvement after taking fetal protection measures, it will also recommend that you give up as soon as possible and do miscarriage. Because in this case, it is very likely that the embryo itself is not good, and there is no point in preserving the fetus. If the fetus is forcibly protected, even if the fetus is successful, the fetus will face more tests in the later pregnancy, and even encounter fetal stoppage, and then do abortion later, and the expectant mother will also increase the danger.
Common misunderstandings in the first trimester
Condition: The presence of brown discharge is bleeding
Myth: Go to the hospital to find a doctor to prescribe medicine to take progesterone
The brown discharge represents previous bleeding, most likely from trauma during implantation, and is later discharged with delayed vaginal discharge, which is normal.
Pink, bright red, non-viscous, heavy bleeding, or persistent bleeding is the only thing to look out for if there is a miscarriage. This brown discharge usually passes in small amounts in two or three days and will not be there again.
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About progesterone fetal preservation
With the use of large amounts of progesterone in the first trimester, the risk of deformities in the fetal spine, anus, limbs, etc. can be increased by 8 times. If synthetic progesterone is used (such as norethindrone has a virilizing effect), about 18% of female fetuses are virilized.
The use of progesterone in the normal situation of progesterone deficiency does not bring danger, so we must correctly understand progesterone, correctly understand the different factors of miscarriage, and correctly understand fetal preservation.
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How to supplement with progesterone
It is necessary to find out whether there is a lack of progesterone. It is true that in the case of insufficient luteal function, progesterone injections can be given for 3-4 days from the rise in basal body temperature in order to conceive, and use them uninterruptedly for 9-10 weeks until the mother can naturally secrete progesterone.
It is best to go to a regular hospital to confirm pregnancy
Because the test strip test is uncertain, if you want to confirm whether you are really pregnant, you still have to go to the hospital for a more accurate test!
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Blood hCG test
This method is to check the blood for the presence of chorionic gonadotropin, which is currently a more accurate method of early pregnancy testing, more sensitive and accurate than early pregnancy test strips.
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B-ultrasound examination
This kind of examination needs to be more than 5 weeks pregnant at the earliest, and the circular halo in the uterus is seen in the B ultrasound examination, which represents pregnancy, and it can also check for ectopic pregnancy through this examination, and the abnormality of pregnancy can be detected early.
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