Ms. A and Ms. B underwent ivy infant transfer on the same day and on the same day, 2 weeks after the transplant, went to the hospital for blood test HCG. Luckily, both were pregnant! Delighted, the two compared their HCG results: Ms. A's HCG value was 232 IU/L, and Ms. B's was 500 IU/L.
At this time, Ms. A was not happy: everyone was in the same process, why would her HCG value be twice as high as mine?
What exactly is HCG
HCG is a human chorionic gonadotropin that promotes the continuous secretion of estrogen and progesterone, the formation of uterine decidua, and the maturity of placental growth.
The changing pattern of HCG after pregnancy
If the embryo implants smoothly and the villi trophoblasts begin to secrete trace amounts of HCG, HCG levels double in about 2.2 days during the first 10 weeks of pregnancy, which is known as "HCG doubling". After the embryo implants, the HCG in the maternal blood increases exponentially, peaking at weeks 8 to 10 gestations, peaking for about 10 days, about 12 weeks, and rapidly decreasing until it remains stable after weeks 18 to 20.
When is HCG monitored?
HCG monitoring has two methods, blood test and urine test, but there is only a small amount of HCG in the urine, especially after dilution, there is often a problem that the results are not accurate enough, and blood test is the most accurate pregnancy measurement method.
Urinary HCG: can be detected 12-15 days after fertilization
Blood hCG: fertilization can be detected in 6-8 days
HCG measurements < 3.1 IU/L: not pregnant
HCG measurements > 5 IU/L: conception is possible
When the HCG measurement value > 10 IU/L: Pregnancy is confirmed
Why is your HCG transplanted twice as bad as someone else on the same day?
Important conclusions say N times -
It doesn't make sense to just look at the HCG value size!
It doesn't make sense to compare sizes between individuals!
This one doesn't have to be rolled...
1 The degree of development varies
IVF is transferred on the same day and blood HCG is tested on the same day, but the degree of embryo development at the time of transfer is different. Embryos that develop longer have more trophoblast cells and higher blood hCG levels.
Example: Ms. A and Ms. B are transferred on the same day, Ms. A transfers a fissile embryo that develops to day 3, and Ms. B transfers a blastocyst that develops to day 5. Half a month later, both became pregnant.
The embryos on days 2-3 are in the cleft phase, with only cleft bulbs and have not yet differentiated into trophoblast cells, while blastocysts are embryos that have developed to the 5th day and have differentiated into a trophoblast layer. Therefore, if it is the same day of transplantation, the transplanted blastocyst can be said to have "won at the starting line", so the blood HCG level on the day of the test will look higher.
2 Causes of singletons and multiple tires
The blood hCG value of twins in multiple pregnancies will generally be higher than that of singletons, but this does not mean that a high blood value is necessarily a twin. At present, the diagnosis of single twins, B ultrasound is still the gold standard, and it cannot be completely considered that high blood value is twins.
3 Differences in implantation time
One theory is that even embryos of the same degree of development may have different timings of implantation into the uterine lining, and that if the embryo implants earlier and secretes more HCG earlier, the HCG detection value will be higher.
4 Individualized differences in the rate of embryonic development
For embryos, due to different specific developmental potentials, there are also possibilities such as slower division of trophoblast cells and obstruction of the process of invading the inner membrane. The rate of development of each embryo cannot be exactly the same, just as all first-grade children will have objective differences in height, weight, learning ability and athletic ability.
Many sisters like to take their own values and compare them with others. Once you see that other people's values are much larger than your own, your heart is very unsteady, and you are worried that the embryos will not develop normally.
In fact, due to each person's different physical condition, the implantation time of the fertilized egg is sooner or later, and other reasons, everyone's HCG level will be somewhat different.
The key to judging whether the embryo is normal is not the level of the HCG value, but the speed of HCG growth! This is often said to be doubling. As long as the doubling is normal, there is no need to worry too much, and it will always rise in the later stage.