With acne and oil control, Bansai's "physical output" can defeat magic

@Sasaki Aoyama

Master of Dermatology and Venereal Diseases, China Medical University

Give you back the original beauty

Here's the thing, I received a task from @Hokusan with the title "The Past and Present Lives of Ban Sai". Ban Sai is a common topical drug used in the treatment of mild to moderate acne, and we dermatologists are familiar with it. However, is there anything wrong with this thing, repeatedly pondering the text sent by @Beilan "We have a topic, I think it is very interesting!" ....”

Did Ban Sai really have a horrible past like botulinum toxin as a biological weapon in World War II? Or does metformin have all sorts of new features that break through existing perceptions? Since @Beilan has said so, there must be something remarkable about it. So I spent hours in full swing looking up the major Chinese and English databases.

As a result, nothing remarkable happened.

So I asked @Hokusan if she had found any wonderful stories related to Ban Sai. It didn't, it didn't! The title is set so casually.

I don't care, give the salary, I earn this fee!

What is Ban Sai?

Now let's start with this Bansai, the word "Bansai" is actually a trade name, it is a 5% benzoyl peroxide gel produced by the French pharmaceutical company Goldemet.

@Saigon is right, it's "strong" because Benzoyl peroxide (BPO) is a strong oxidant. BPO was first made in 1905 and began to be used as a drug around 1930. It is included in the World Health Organization's Standard List of Essential Medicines. In addition to being a mild to moderate acne treatment drug, in fact its application in industry is more extensive.

Image source: Network

BPO can be used as an initiator and curing agent for free radical polymerization reactions in the plastics industry. There are also hair bleaching, teeth whitening, textile bleaching, etc. [1]

It was also used for flour bleaching, but since May 1, 2011, the addition of BPO to flour has been prohibited in mainland China. At present, the FAO/WHO UN Food Regulation Commission still allows the use of benzoyl peroxide in flour, as does countries such as the United States, Canada, Australia, and New Zealand.

BPO itself has no carcinogenic, teratogenic, mutagenic effect, it is eaten with food, metabolized by the liver, 90% can be combined with glycine into equeous uric acid with urine excretion, part of the glucuronic acid combined into a benzoyl glucuronic acid and greatly reduced toxicity, the maximum amount of use in the mainland at that time was 60 mg / kg, according to the standard provisions of the use will not cause harm to human health. [2]

However, at the same time, there is controversy, that because BPO decomposes benzoyl, benzoic acid, phenol, etc. in the flour detoxification in the liver, causing liver burden, it will cause neurasthenia, dizziness and fatigue, etc., in addition, the β contained in the flour - carotene and vitamins A, E, B and other micronutrients have a strong destructive effect, so it is harmful to the human body. [3]

So in 2011, the Ministry of Health, the Ministry of Industry and Information Technology and other 6 departments issued an announcement, since there is a controversy, flour bleaching is a "non-essential" technology, simply banned! look at! We Chinese can be more exquisite and healthy than some developed countries in terms of eating.

Bansai's effect on the skin

Going back to our dermatology content, BPO is mainly used to treat skin diseases such as acne and pimples caused by Propionibacterium acnes. BPO has been effectively used in the treatment of acne for 60 years. [4]

How was benzoyl peroxide found to treat acne? In 1952, a compound chlorohydroxyquinoline ointment called "Quinilor" produced by Bristol Squibb Pharmaceuticals was popular, which was particularly effective in treating acne, but it had a thick skin feeling and unpleasant color and smell.

Later, Willam E. Pace dermatologists in the Medical Department of Weston University determined the composition of the ointment and found that the active ingredient of the ointment was benzoyl peroxide, and finally in 1961 a clinically effective and beautiful oil-in-water emulsion of benzoyl peroxide ointment was born. [4]

The first BPO gel was approved for marketing in Canada in 1992, followed by other countries, and imported in mainland China in 2002.

BPO is a strong oxidant that can be decomposed into reactive oxygen species and benzoic acid on the skin to achieve sterilization, anti-comedone, and oil control.

BPO has a broad spectrum of bacteriostatic effects because it relies on the "physical output" of strong oxidation, rather than the "magic attack" of antibiotics relying on pharmacology, so drug resistance does not occur. It has an effect on gram-positive bacteria, gram-negative bacteria, candida, etc., and is more effective against the anaerobic bacteria of Propionibacterium acnes, BPO can destroy the hypoxic environment in which acne bacilli survive by releasing reactive oxygen species and decomposing them to be weakly acidic benzoic acid. [5]

As for how to achieve oil control? It is not directly de-oil-controlled, but through indirect action.

Due to the proliferation of Propionibacterium acnes to produce lysase, the triglycerides in the decomposition of sebum produce free fatty acids, which stimulate the sebaceous glands of the hair follicle to produce inflammation, and inflammation further induces increased sebum secretion. BPO eliminates these bacteria, reducing free fatty acids on the surface of the skin. Bansai gel can effectively adsorb excessive sebum on AC particles due to the addition of glycerol-rich acrylic lipid copolymer particles (AC preparations), strengthening the oil control effect of benzoyl peroxide. Glycerin in turn moisturizes the skin, reduces skin dryness and irritation, thereby reducing the side effects of the drug. [6]

Are there any side effects in Ban Sai?

Common side effects of Bansai include skin irritation, dryness and peeling.

Therefore, the first few days of use, only for 1 to 2 small areas, in the way of spot coating, to see if there is any allergy or irritation, such as the problem is not big, and then gradually increase the use area, do not be anxious to use a large area at the beginning, if you can not stand the stimulation, rinse with water as soon as possible. Drug irritation can also be reduced by applying a layer of moisturizer primer before use.

Also take care not to get bangser into mucous membranes such as eyes or mouths and on broken "pimples". BPO will bleach clothing and hair, so be sure to wash your hands before and after use.

1 - 3 times a day, if the skin tolerates, multiple use works well. Ban Sai has a quick onset of action, with generally visible improvements in 2 to 3 weeks and significant improvements at 8 to 12 weeks.

Combining with other medications to treat acne can increase efficacy and reduce the incidence of adverse reactions.

Bansai's classic CP, Adapalene Gel, can play a 1+1 >2 effect. It is generally recommended to use Ban Sai in the morning and Adaparin in the evening.

Ban Sai and antibiotics are paired to improve the efficacy and shorten the duration of antibiotic use and reduce the rate of antibiotic resistance.

In addition, regarding whether children, pregnant women, and lactation can be used, the current safety level of pregnancy medication is C-level, and the ban sai instructions are written on the instructions for pregnant women to avoid use, lactation should be used with caution, and the domestic benzoyl peroxide gel instructions do not have this provision. Children are required to use under adult supervision.

In my opinion, I used to eat it with flour, so I don't have to worry about this content of external medicine, I should use it.

summary

1. The main ingredient of Ban Sai is benzoyl peroxide (BPO), which is a strong oxidant.

2, it is in addition to the treatment of acne, in the industry, life is more common, ordinary and great existence.

3, Ban Sai is irritating, using it requires a small amount, low frequency, small area to start, and gradually establish tolerance.

4, children, pregnant women, lactating women as long as the doctor prescribed this drug, although the use.

This article is authorized to be reproduced from the public number: Yu Xi sister

bibliography

[1] Liu Changsheng, Yu Xianghua, eds., Comprehensive Experimental Course in Polymer Chemistry and Polymer Physics, China University of Geosciences Press, 2008.11, p.91.

[Ding Xiaowen, Liu Chunhong, eds., Food Safety, 2nd Edition, China Agricultural University Press, 2016.09, p.137.

[3] Zhu Hongfa, Editor-in-Chief, Living Chemicals and Health, Jindun Press, 2013.04, p.131

[4] Frank L. Active oxygen acne therapy—oxygenation vs. reductionofthe follicular structures. Cutis. 1965;1:30.

[5] Huang Jun, Huang Zuhu, eds., Clinical Drug Manual 5th Edition=Clinical handbook of drugs, Shanghai Science and Technology Press, 2015.01, p.1731

Yang Yi.Observation on the efficacy of 5% Bansai in the treatment of acne vulgaris[J].Journal of Sichuan Provincial Health Management Cadre College, 2002(02):124.