Food, I want it, the body is also what I want, the two can not be combined, continuous dry food, intermittent weight loss.
Exercise, I hate also, boiled vegetables are also my evil, weight loss is far away, but I hope that scientists will develop safe and efficient diet pills as soon as possible, if you want, believe in women (letter men) wish to be accompanied by hot pot milk tea for a lifetime.
Scientists from Nanyang Technological University in Singapore heard the voice of the majority of weight loss people, developed a new type of photothermal gel, injected into the subcutaneous fat, with in vitro near-infrared light irradiation, photothermal conversion, directly "ignited" adipose tissue, easily lose weight by 15%, burn more than 40% of fat, improve metabolism, and truly achieve "I do not move fat, sit and enjoy the small wild waist"! The research results were recently published in ACS Nano, a well-known journal in the field of materials science.
Figure note: The new photothermal gel looks like this!
Speaking of the principle of light and heat gel weight loss, in fact, there are some differences with eating spicy weight loss, and their targets are capsaicin receptor TRPV1 - when the TRPV1 receptor on the surface of fat cells is activated by capsaicin or temperature, the white fat of "fat storage" begins to transform into "fat-burning" brown fat, accelerating lipolysis and reducing body fat.
Figure note: Photothermal gel weight loss principle, TRPV1 receptor activation, promote fat browning, degradation, adiponectin release, adipose tissue neovascularization, etc
Since they are all targeting the same TRPV1 receptor, is it not delicious for us to eat spicy weight loss directly?
However, in years of research, eating spicy weight loss is not so reliable, the weight loss effect varies from person to person, if there is nothing, and for most people, before the belly is thin, chrysanthemums suffer first.
The new photothermal gel does not have this concern, through the painless insulin needle directly injected into the subcutaneous adipose tissue, in vitro near-infrared light irradiation, the gel in the adipose tissue began photothermal conversion, heating, when the temperature exceeds 42 ° C, it can activate the TRPV1 receptor.
Illustration: Illustration of the use of photothermal-drug therapy
And this gel is in a liquid state at room temperature, easy to inject, once it enters the internal environment of the human body at 37 ° C, it quickly forms a gel, does not flow at will, and produces heat at a fixed point in the adipose tissue to avoid burns to the skin or surrounding organs.
In terms of safety, in in vivo experiments in mice, the gel can be safely metabolized by the liver and kidneys, and no abnormalities in various organ anatomy and hematological analysis have been found, proving the degradability and biocompatibility of the product.
Note: After the injection of photothermal gel, the liver and kidney function and hematologic indicators of mice changed
In terms of weight loss effect, the same are high-fat diet feeding mice, the control group of mice in two weeks, weight increased by 9.5%, and the use of light and heat gel weight loss of mice, eat more, but people do not grow fat but also lost weight, weight loss of 4.1% -7.6%, subcutaneous fat volume decreased by 27% -33%, visceral fat volume decreased by 44% -46%!
What is the concept of visceral fat volume reduction? That is to say, the photothermal gel injected into the subcutaneous fat tissue not only burns the subcutaneous fat, but also beats the cattle across the mountain, so that the fat of the whole body is reduced!
Note: Control control group, NIR simple near-infrared irradiation group, CuS-L + NIR low-dose photothermal therapy group, CuS-H + NIR high-dose photothermal therapy group
However, there is a bit of a fly in the ointment, although the photothermal therapy has reduced the fat volume, but it has not improved the metabolism of obese mice fed by high-fat diets, the level of cholesterol and triglycerides in mice is still very high, coupled with the large amount of fatty acids produced by the fat degradation process is still accumulated in the blood, even if the insulin level in the mice has decreased, the situation of insulin resistance still exists (insulin level × free fatty acid levels).
Therefore, the researchers decided to add another member of the photothermal gel - Mirabegron, a beta3 adrenergic receptor agonist approved by the FDA for the treatment of bladder hyperactivity, which accelerates the conversion of fatty acids into heat energy while promoting fat degradation and maintaining blood lipid homeostasis in the body.
Sure enough, with Mirabegron-blessed photothermal gel, that is, photothermal-drug therapy, the weight loss effect was further improved, and the metabolism in mice on a high-fat diet was greatly improved:
Under the action of photothermal-drug therapy, the high-fat diet mice lost 15% in body weight, 40% less subcutaneous fat, and 54% less visceral fat volume!
Photothermal-drug therapy Mir+CuS+NIR has a significant effect on weight loss
At the same time, the mice's serum cholesterol levels decreased by 54%, triglycerides by 18%, insulin levels by 74%, blood sugar by 45%, and insulin resistance index by 65%.
Photothermal-drug therapy Mir+CuS+NIR improves metabolism in mice.
Finally, according to the researchers, photothermal-drug therapy is simple and easy to operate at home, a bottle of gel, an insulin needle (almost painless, all diabetics at home understand), a handheld near-infrared tube, and a flat abdomen!
So that is to say, when can human clinical trials be carried out, this weight loss enthusiast is willing to offer belly!
bibliography:
[1] Zan P, Than A, Zhang W, Cai HX, Zhao W, Chen P. Transdermal Photothermal-Pharmacotherapy to Remodel Adipose Tissue for Obesity and Metabolic Disorders [published online ahead of print, 2022 Jan 3]. ACS Nano. 2022;10.1021/acsnano.1c06410. doi:10.1021/acsnano.1c06410
[2]https://medicalxpress.com/news/2022-01-therapeutic-approach-tackle-obesity-lab.html
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