Zhang Wenhong posted a long article on Weibo about China's anti-COVID-19 oral drugs, Omi Kerong and personal dynamics

Recently, the international community is in a very high-risk period of the new crown epidemic. The pressure on imported outbreaks is enormous. On January 11, a case of imported asymptomatic infection in Shanghai was abnormal on the seventh day of nucleic acid testing during the health monitoring period after the expiration of the isolation period, which caused a round of concern. In fact, the situation during the monitoring period of such inbound personnel is handled according to the norm, and it is unnecessary to over-interpret it. Just remind the relevant personnel that they must conscientiously perform this health monitoring period in the future, make themselves safer, and make the people around them safer.

During this time, the epidemic prevention troops in various places can be said to be "walking on thin ice and waiting for the pillow". Once there are local infected people, the epidemic prevention force is not overnight, all close contacts and sub-close contacts will be the first time to control, through fine and rapid work, so that the virus can be controlled, hoping to prevent and control the virus, but also try to make life and work normal operation.

This morning, my COVID-19 treatment team in the hospital office once again combed through all the inpatient cases. The number of imported infected people in the new crown ward of Shanghai Public Health Clinical Center has also exceeded the all-time high, and we compared the clinical characteristics of the Aomi Kerong variant with the previous Delta variant, which is faster and more hidden than the Delta, but still has a lethality that cannot be ignored. Subsequently, he discussed with the scientific research team the recent progress of protective research on Opmicron after vaccine enhancement injection, and also prepared for the upcoming clinical research of a new class of oral anti-COVID-19 oral drugs developed and innovated by China itself. Vaccines and drugs will be the core scientific and technological support for us to survive the pandemic and return to normal life in the future, and China's scientific and technological forces, like the epidemic prevention forces, have been working tirelessly to smoothly tide over the pandemic and save our people from the fear of infectious diseases.

The team also had an in-depth discussion on WHO's newly summarized Recommendations for Prevention and Control of Omikeron. Based on the current global evidence, WHO has given new recommendations for prevention and control, which are of great reference for understanding the differences in the strategies of international countries to fight the epidemic. The international prevention and control situation is in the midst of great uncertainty and rapid transformation of prevention and control models, and WHO has issued a new scientific summary for Omi Kerong, including the following:

1. The Omirkjong mutant has evolved to replace Delta, the old overlord of the new crown world. On January 10, the number of new infections in the United States exceeded 1.43 million, the highest daily statistic for a single country in the world since the COVID-19 pandemic. This figure will reach a new high in the near future. In this most recent week of New Year's Eve (26 December 2021 to 2 January 2022), the global weekly incidence increased by 71%. But at the same time, the number of hospitalized patients in these countries has not yet exceeded last year's peak, and the overall disease case fatality rate continues to decline. This phenomenon can easily create the impression that the world is more adapted to the continued epidemic of the new crown virus.

2. In this context, WHO's newly published opinion on the Omiljunn epidemic ("Member States' Strengthening of the Global Infection Brief and Priority Recommendations for the Omiljunn Variant"), updated on 7 January, notes that the incidence of community transmission in Omilkeron is very high, and that a significant increase in hospitalizations has already occurred in countries and is intensifying. As transmission in Olmiqueron is expected to rapidly increase the number of cases, pressure on health systems will increase significantly, being overloaded and dangerous for most countries with limited medical resources. The necessary health-care resources must be ensured to be in place to cope with possible surges in demand.

3. In this case, countries are not currently fully liberalized, but are implementing moderate tightening strategies according to the degree of run on medical resources, WHO specifically points out that in areas where vaccines are not adequately covered and medical resources are relatively scarce, public health and social management measures should continue to be implemented to reduce the rate of transmission of Omi kerong, so as to avoid a run on medical resources, which in turn leads to a high case fatality rate. It is highly recommended that public health and social interventions should be implemented comprehensively, multi-layeredly and targeted to slow the spread of the Aomi Kerong variant.

4. Vaccine protection against Amiqueron has declined. Early data suggest that vaccines are less effective against Emilion infections, illness and hospitalization than Delta virus. At the same time, there is evidence that homologous and heterologous booster vaccination can increase vaccine efficacy and still maintain a protective effect against severe COVID-19.

5. Since the outbreak, the current phenomenon is that the vast majority of young people who have been fully vaccinated can survive safely, while most of the hospitalized patients are unvaccinated, while the elderly, infirm, and high-risk groups with low immunity are the main targets of severe COVID-19.

Based on the above information, it can be judged that the global risk caused by the current NEW CROWN strain is still very high. Despite indications of lower severity, Omikeron has spread faster in the community than Delta, leading to a surge in hospitalizations and serious consequences and burdens on the health system and other relevant sectors. Humanity's struggle with Aomi Kerong is still in its most difficult moment.

There are also indications that the situation is moving in favour of humanity. China's best strategy at this time is to maintain strategic determination and patience, maintain the strategy of strengthening vaccination and public health prevention and control strategies, exchange time for space, and finally at the most appropriate time node, successfully pass the pandemic period with a very low COVID-19 mortality rate, and gradually normalize life.