Omikrondo "poison"? How to protect the "double section"? Analysis of guangdong chief scientist of disease control

Text/Yangcheng Evening News all-media reporter Zhang Hua correspondent Zhong Ruoxi

At present, the Omikeron variant has become a major epidemic in South Africa, Botswana and some cities in the United Kingdom and the United States, and has spread to at least 121 countries and regions. Many provinces in China and Hong Kong, Macao and Taiwan have reported the detection of imported Cases of Aumecreon and related local cases. How strong is the spread of the Omiljun strain? Before the Arrival of New Year's Day and Spring Festival in 2022, how can we do a good job of protection? In this regard, the Yangcheng Evening News all-media reporter interviewed Lin Peng, chief scientist of the Guangdong Provincial Center for Disease Control and Prevention.

Doubts: Omi kerong has strong transmission power and a high risk of family recurrence

It is reported that the spread of the Omikejong mutant strain is very strong, and it may be infected in just a few minutes of contact. In this regard, Lin Peng said: "Compared with the other four new coronavirus strain VOCs (Alpha, Beta, Gamma, Delta), the Aomi Kerong strain has more spike protein mutation sites, and some mutation sites are shared with these 4 VOCs. The sites of these variants have been shown to be associated with increased cell receptor affinity, viral replication capacity, and immune evasion. The influence of some of the new mutation sites in Omicron needs to be further studied. ”

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As of 29 December, Guangdong Province has reported a cumulative total of 31 cases of Omi kerong (including imported and locally associated cases). Lin Peng pointed out that through observation and research, it was found that the characteristics of the Aomi Kerong mutant strain mainly have the following three points:

First, the virus load is higher and the spread force is enhanced. Domestic and foreign studies have shown that the effective regeneration number (Rt) of Omicron in the UK is about 6, and the doubling time is about 2.2 days, which is more powerful than The Delta. The team at the University of Hong Kong School of Medicine found that 24 hours after infection, the viral load in human bronchial tissue was nearly 70 times higher than that of Delta. Omikeron also has the characteristics of faster copying speed and stronger replication ability. As a result, it is at higher risk of causing recurrence in the home.

Second, mild diseases are the main ones after infection. Due to the lag in the time from onset to severe illness and death, the clinical severity caused by Omi kerong still needs more data to be explored. Lin Peng said that as of now, the vast majority of infected people have only shown mild symptoms or no symptoms, with fewer severe cases and very few deaths. Researchers in South Africa and the United Kingdom found that those infected with Omikerong were at lower risk of severe illness than those who were not infected with Omikeron and those who were infected in early Delta in the same period.

Third, there is immune escape, but vaccination can still avoid severe disease. "The study found that Omiljung had a significant escape from previous infections and vaccination-induced humoral immunity, but full vaccination still greatly protected people from severe illness." Lin Peng also introduced that another US study shows that cellular immunity is not greatly affected by Omilon, and enhanced vaccination, especially heterologous enhanced vaccination (such as: inactivated virus vaccine + recombinant protein subunit vaccine / mRNA vaccine), can significantly improve the body's neutralizing antibody titer. Studies have shown that pan-coronavirus vaccines may be the focus of future research and development of COVID-19 vaccines.

Appeal: "Two festivals" are coming, and cross-provincial arrivals in Guangdong take the initiative to test nucleic acids

New Year's Day and Spring Festival "two festivals" are approaching, there are many people gathering, the flow is also large, how to do a good job of protection? In this regard, Lin Peng suggested "two restrictions, two avoidances, and one promotion" of scientific travel.

Specifically, on the one hand, the "two restrictions" are to strictly restrict the travel of people in medium- and high-risk areas and the county (city, district) where they are located, and it is recommended that personnel from other counties (cities, districts) in the cities where medium- and high-risk areas are located do not travel across provinces without necessity; on the other hand, they restrict non-essential non-travel to other counties (cities, districts) of the cities where medium- and high-risk areas are located.

"The 'two avoidances' are to avoid traveling to land border port cities outside the province as much as possible; high-risk positions (such as cross-border truck drivers, international flight crews, etc.) try to avoid inter-provincial travel, and if they need to travel, they are required to leave their jobs for more than 14 days and hold a 48-hour nucleic acid negative test certificate, and report it at the unit." One advocates 'that is, to advocate the completion of a nucleic acid test in a timely manner after the arrival of cross-provincial mobile personnel in Guangdong and return to Guangdong, and to strengthen self-health monitoring. Lin Peng said.

During the Spring Festival, the number of people returning to their hometowns to pay respects to the New Year increased Lin Peng reminded that it is necessary to strictly do a good job in the ventilation and disinfection of the bazaars, village (resident) people's activity rooms, chess and card rooms, as well as scenic spots, homestays, restaurants, ancestral halls, temples and other places. When citizens enter the above places, they should cooperate with measures such as wearing masks and health code inspection.

At the same time, it is also necessary to strengthen the management of gathering activities. Lin Peng suggested that no more than 10 people should be included in family dinner gatherings, and if they hold banquets with more than 5 tables and other dinner activities, they must report to the local community neighborhood committee or village committee in advance to implement the territorial prevention and control regulations.

In addition, he stressed that people who meet the vaccination conditions and have no contraindications to vaccination should complete the full vaccination of the new crown vaccine as soon as possible, especially the elderly aged 60 and above and key groups should be fully received. People aged 18 years and over who have completed the full vaccination for 6 months should be vaccinated as soon as possible. (For more news, please pay attention to Yangcheng Pie pai.ycwb.com)

Source | Yangcheng Evening News Yangcheng Pie

Editor-in-charge | Zheng Zongmin