Cerebral infarction is a common cerebrovascular disease, a group of syndromes caused by a variety of factors, with complex risk factors and a varied pathological process. The principles of treatment are to improve cerebral circulation, resist platelet aggregation, increase cerebral blood flow, and reduce the degree of impaired nerve function. At present, western medicine treatment is highly targeted, but the target of action is single, while Chinese medicine is known for its comprehensive effect. Ge Ke Tongluo capsules and Blood Vein Kang capsules are just in line with the treatment principles of cerebral infarction, so the clinical effect is obvious.
Gerone capsules
Ge Ke Tongluo Capsule is a new drug of the second class of traditional Chinese medicine developed and produced by the Institute of Medicinal Plants of the Chinese Academy of Medical Sciences and joint pharmaceutical companies, which has the effect of activating blood and dissolving stasis. It is used for meridian recovery period of ischemic stroke, blood stasis and obstruction of choroid evidence, symptoms such as half-body failure, crooked mouth and tongue, partial body numbness, unfavorable language, dizziness, strong neck pain, etc. Atherosclerotic thrombotic cerebral infarction and lacunar cerebral infarction are seen in the superior.
Modern pharmacological studies have shown that the main active ingredient of kudzu ketone capsules is the ethanol extract of kudzu root total flavonoids, including pueraria, soy glycosides, soybean flavonoids and soy flavonoids. Mainly by inhibiting the formation and progression of atherosclerotic plaques, scavenging the production of oxygen free radicals in the brain, inhibiting nerve cell apoptosis, anti-platelet aggregation and other effects, so as to play a role in protecting nerves and anti-cerebral infarction.
Inhibition of the formation and development of atherosclerotic plaques: Atherosclerosis and embolism caused by rupture of vulnerable plaques are the main pathogenesis of cerebral infarction, and are closely related to the occurrence, development, recurrence and site of cerebral infarction of the disease. Kudzu total flavonoids effectively reduce the viscosity of the blood, the effect of pathological conditions is more obvious, reduce platelet adhesion rate, improve plasminogen activity, and then inhibit the formation and development of atherosclerotic plaques.
Antioxidant and oxygen scavenging free radical effect: Experiments have proved that kudzu total flavonoids have a strong antioxidant, scavenge oxygen radical ability, and by improving the activity of superoxide dismutase (SOD), reducing malondialdehyde (MDA), eliminating oxygen radicals and anti-lipid oxidation, thereby achieving the purpose of reducing brain tissue damage. After cerebral infarction occurs, the stimulation of ischemia and hypoxia leads to the normal metabolic imbalance of free radicals, on the one hand, a large number of free radicals accumulate, and the production of lipid peroxidation productS such as MDA increases; on the other hand, SOD is continuously consumed and significantly reduced, and the antioxidant damage ability is weakened, and brain tissue and nerve cell damage occur.
Inhibition of nerve cell apoptosis: Apoptosis after cerebral infarction directly determines the number of nerve cell necrosis and the area of the infarction area. Therefore, timely and effective anti-apoptosis is expected to become an effective treatment for cerebral infarction. Kudzu total flavonoids increase the activity level of glutathione peroxidase and SOD, reduce the content of MDA, reduce the expression of the most important terminal shearing enzyme in the process of apoptosis, further reduce the degree of apoptosis of nerve cells, and exert cerebral protection.
Pulse Blood Kang capsules
Pulse Blood Kang Capsule is a kind of unilateral proprietary Chinese medicine produced by leech as raw material using low temperature control technology, which has the effect of breaking blood, stasis, pulse relief, and its main active ingredient is hirudin. Hirudin is an anticoagulant protein that blocks the action of thrombin on fibrinogen and prevents blood from clotting.
Leech can activate blood stasis, activate the fibrinolysis system, and promote the formation of thrombolysis. Leeches also secrete a histamine-like substance that dilates capillaries. Hirudin inhibits thrombosis growth more effectively than heparin, etc., accelerating the decomposition of blood clots on the walls of the tubes that already exist. Hirudin is the strongest known thrombin-specific inhibitor and is a good adjunct to thrombolytic drugs.
Pulse Blood Kang capsules can regulate the constriction disorder of cerebral blood vessels, dilate cerebral blood vessels, and help improve the blood supply of ischemic brain tissue. Clinically used in the treatment of acute cerebral infarction, we have observed that it can reduce the production of cross-linked fibrin, regulate the abnormal state of blood coagulation, reduce blood viscosity, help improve microcirculation and cell metabolism of ischemic brain tissue, and protect brain cells.
Studies have shown that Pulse Blood Kang capsules can promote the synthesis of nerve growth factor and brain-derived neurotrophic factors, which have the effect of nourishing nerves and promoting the repair and regeneration of cerebral infarction neurons. At the same time, it can regulate free radical metabolism, reduce the accumulation of free radicals in the body, avoid secondary damage to neurons, and thus protect the central nervous system. In addition, Pulse Blood Kang capsules also have the effect of promoting the opening of collateral circulation.
Pulse Blood Kang capsules are commonly used to treat ischemic cerebrovascular disease. Not only does acute cerebral infarction have the effect of reducing infarction foci and improving the quality of life, but also improve the patient's blood lipid level, plasma viscosity and platelet aggregation rate during the recovery period of cerebral infarction. It can also be used to treat transient ischemic attacks, insufficient blood supply to the vertebro-basal arteries, etc., which can dilate cerebral blood vessels, improve blood circulation, increase cerebral blood flow, and improve clinical symptoms.
In short, Ge Ke Tongluo capsules, pulse blood Kang capsules, although only composed of a kind of traditional Chinese medicine, but the extract is the essence of the pharmacological effect, the so-called medicine is not much, expensive in the fine. For blood-stasis cerebrovascular diseases, it is broken down from many aspects such as inhibition of atherosclerosis, auxiliary thrombolysis, antioxidants, scavenging free radicals, and inhibition of apoptosis of nerve cells.