"If 'Lianhua Qing plague' has never been strictly proven to be effective, then the forcible delivery of 'Lianhua Qing plague' will harm the masses waiting for necessary supplies and medicines."
Written by | Tian Dongliang
Source | "Medical Community" public account
Since its listing, Lianhua Qingpeng Capsules (granules) have been recommended 27 times by the guidelines for the treatment of colds, anti-influenza and prevention and treatment of new crown according to the statistics of its production enterprise Yiling Pharmaceutical. However, the controversy and questioning surrounding its validity has not been broken.
Today (April 17), the WeChat public account "Rao Yi Science" published an article "During the epidemic period: counterfeit drugs are not allowed to take advantage of the fire to loot, it is not appropriate to forcibly distribute unproven Chinese medicine", and the spearhead is directed at Lianhua Qing plague capsules (granules). The WeChat public account belongs to Professor Rao Yi, president of Capital Medical University, and the article reads:
Today, in areas where COVID-19 is raging, the allocation of materials is intense. Sometimes, in some areas, it is difficult to ensure that the food and medicine needed by the people will reach the hands of the masses on time. Under such circumstances, if the compulsory distribution of drugs to prevent or treat the new crown, it must be strictly tested, and counterfeit and inferior products must not be forcibly distributed to the masses with any hat , including the hat of "traditional Chinese medicine".
Because if it is a counterfeit drug, it is not only useless, but also affects the distribution of important materials.
If it is a counterfeit medicine, wearing the hat of "Chinese medicine" damages the reputation of truly effective Chinese medicine and affects the credibility of truly effective Chinese medicine.
In Shanghai, where the new crown epidemic is raging today, many families have to worry about food, and there may be a lack of emergency medicines at home, but there must be no shortage of Lianhua Qing plague. Under the condition that the food purchased online is difficult to deliver, Mr. Tian, who lives in a sealed control community in Hongkou District, has received four boxes of Lianhua Qing plague capsules (granules) twice, and the vegetables sent by the community have only received once.
According to an information on the homepage of the official website of Yiling Pharmaceutical, following the donation of 10 million yuan worth of Lianhua Qing plague to Shanghai on March 28, Yiling Pharmaceutical once again donated 50 million yuan of Lianhua Qing plague on April 3 to help Shanghai prevent and control the epidemic.
Lianhua Qingpest capsules (granules) should be the only drugs distributed in the Shanghai epidemic to prevent or treat the new crown. In this regard, Professor Rao Yi pointed out sharply in the article:
It needs to be very clear whether "Lianhua Qing plague" has indeed been shown to be effective in preventing or treating COVID-19.
If the "Lianhua Qing Plague" has never been strictly proven to be effective, then the forced delivery of the "Lianhua Qing Plague" will harm the masses waiting for the necessary supplies and medicines.
Representative figures such as Wu Yiling, his enterprises, and his products have faced great controversies over genuine drugs and counterfeit drugs for many years, and should be strictly reviewed. If it is a real medicine, it should be returned to its innocence. If it is a counterfeit drug, it should be severely punished, fined a hundred, and eradicated the scammers, their enterprises, and their products that dare to take advantage of the fire during the epidemic.
Before Professor Rao Yi's article, the "Bedtime News Editorial Department" pushed a "Bedtime Message 417: WHO "Recommends" Lianhua Qingpest, who told you? The video verified and verified the news that the World Health Organization recommended Lianhua Qingpeng that had previously circulated on the Internet, and the news made the stock price of Yiling Pharmaceutical rise twice.
After verification, the "Bedtime News Editorial Department" came to the conclusion that the domestic mainstream media had forcefully involved Chinese to the World Health Organization meeting and the Lianhua Qing plague capsule, creating a wrong mass understanding, not only forcibly establishing contacts, but even issuing medals for ugly incidents.
The "ugly incident medal" mentioned in the video refers to Jia Zhenhua, the son-in-law of Wu Yiling, the founder of Yiling Pharmaceutical, in his signed paper on the effectiveness and safety of Lianhua Qing plague, to conceal the interest relationship with Yiling Pharmaceutical. The paper, titled "Efficacy and Safety of Chinese Medicine Lianhua Qingxiao Capsules in COVID-19 Patients: A Multicenter, Prospective Randomized Controlled Trial," was published in Plant Medicine in May 2020.
A year after the publication of the paper, Retraction Watch, a well-known scientific research anti-counterfeiting website, pointed out that Jia Zhenhua, one of the authors of the paper, failed to disclose his personal interests with pharmaceutical companies in the paper, Jia Zhenhua was the son-in-law of Wu Yiling, the founder of Yiling Pharmaceutical, and his wife was a board member of Yiling Pharmaceutical, and their husband and wife also jointly operated a subsidiary of Yiling Pharmaceutical, and Yiling Pharmaceutical was the only production enterprise of Lianhua Qingpeng capsules (granules).
Jia Zhenhua later admitted his interest in The Plant Medicine in the errata documents submitted to Plant Medicine, but denied that his company had participated in clinical trials, and although he was the corresponding author, he did not participate in the actual research or statistical analysis of the paper, and his participation would not reduce the objectivity of the conclusions of the paper.
The "Bedtime News Editorial Department" video said that the original paper clearly stated that the study did not carry out double-blind trials, neither concealed drugs from patients, nor designed a placebo control, even if Jia Zhenhua's interests were ignored, the paper did not provide much credible conclusions.
On April 14, the video of the "Bedtime News Editorial Department" was forwarded by Wang Sicong, who wrote in the forwarded comments: The CSRC should strictly investigate Yiling Pharmaceutical. Wang Sicong's forwarding caused great concern, and on April 15, the stock price of Yiling Pharmaceutical fell to a halt. After that, Wang Sicong edited the weibo, deleted the comment content, and only kept the forwarded video.
How effective are Lianhua Qing plague capsules (granules) in the end? In the description book of Lianhua Qing plague granules, there is a paragraph about "pharmacology and toxicology": in vitro experiments have shown that this product has a certain inhibitory effect on influenza virus, parainfluenza virus type I (HVJ-1), respiratory syncytial virus (RSV), adenovirus type 3 and 7 (ADV3 and ADV7), herpes simplex virus type I (HSV-1) and type 2, SARS virus, Staphylococcus aureus, hemolytic streptococcus A, type B, pneumococcus, and influenza bacillus.
For the above description, the well-known doctor Big V "Chengdu Sewer" commented: There are too many things that inhibit the virus in vitro, including alcohol, iodine, disinfectant and even boiled water. Since the end of 2019, the global anti-epidemic that has continued to this day, Abidor, darunavir, chloroquine phosphate, remdesivir, which once had high hopes, has a strong inhibitory effect on the new crown virus in vitro, and is really used in human trials, and all of them have returned home in the competition with the new crown virus.
"In vitro effectiveness is the result of the laboratory's in vitro cells, and the distance from Earth to Mars is also from clinical effectiveness." Now that there are enough patients, should lianhua Qingpi be patient and complete rigorous medical experiments step by step. "Chengdu Sewers, wrote.
Despite the huge controversy it has faced over the years, it has not prevented Lianhua Qingpeng capsules (granules) from being recommended by the guidelines for the treatment of colds, anti-influenza and new crown prevention and treatment programs 27 times.
Regarding the new crown pneumonia, although the "functional indications" of lianhua qing plague granules clearly states: In the conventional treatment of new coronavirus pneumonia, it can be used for fever, cough and fatigue caused by mild and ordinary types. However, in the "Hebei Provincial Novel Coronavirus Pneumonia Traditional Chinese Medicine Prevention and Control Plan (Trial Sixth Edition)" issued by the Hebei Provincial Administration of Traditional Chinese Medicine on March 24, Lianhua Qingpeng capsules (granules) are not only recommended for medical observation, asymptomatic infected patients, mild, ordinary, and severe covid-19 patients, but also recommended as preventive drugs for adults and children.
In the "Ten Questions on the Prevention of New Coronary Pneumonia in Traditional Chinese Medicine" released on the official website of the Shanghai Municipal Health Commission and the Shanghai Municipal Administration of Traditional Chinese Medicine, Lianhua Qingyi capsules (granules) are also recommended as preventive proprietary Chinese medicines.
However, according to the report of "Shangguan News", Dr. Fang Hong, director of the Department of Preventive Health Care of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, reminded that Lianhua Qing plague is a therapeutic drug, non-preventive medication, and oral administration in advance cannot prevent the new crown, even if the antigen is positive, if there is no fever, sore throat, cough and other symptoms, it is not recommended to take it.
Professor Fang Bangjiang, director of the Department of Emergency Medicine of Longhua Hospital, also said that Lianhua Qing plague is not suitable for use as a preventive drug, Chinese herbal medicine contains a lot of electrolytes, and people with poor spleen and stomach function, gastric ulcers, and poor liver and kidney function are not suitable for taking the drug. Inappropriate preventive measures require attention.
Source: Medical community
Editor-in-charge: Tian Dongliang
Proofreader: Zang Hengjia
Plate making: Wang Juan