Department of Pediatrics, The Fifth Affiliated Hospital of Zhengzhou University: A total of "children" grow up to care for the health of the whole growth cycle

Top News Dahe Health News reporter Zhang Baofu

The Henan Continuing Medicine Education Project "New Knowledge Forum on Pediatric Digestion and Nutrition" takes Tang Youcai, vice president of the Fifth Affiliated Hospital of Zhengzhou University, as the theme of "Royal Children's Gastrointestinal, Child Health Care", aiming to promote the health level of children through the management of gastrointestinal tract.

In fact, the Fifth Affiliated Hospital of Zhengzhou University not only protects children's physical and mental health through the way of "royal gastrointestinal", but also escorts children's full growth cycle.

The Department of Pediatrics of the Fifth Affiliated Hospital of Zhengzhou University (hereinafter referred to as "Zhengda Fifth Affiliated Hospital"), which has a history of more than 100 years, is an innovative team integrating medical treatment, teaching, scientific research, health care and rehabilitation. Over the years, the pediatrics of the hospital has faced the world, carried out in-depth cooperation with well-known pediatric experts at home and abroad, actively introduced high-level talents, continuously improved policies, expanded platforms for talent training, scientific research and research, and provided high-quality, low-cost, timely and comprehensive services for countless families with the benevolence of doctors.

Focus on early childhood development and assessment from 0 to 6 years of age

In March this year, in the "Henan Growth and Development Clinic Promotion Activity Most Trusted by the People" carried out in Henan Province, after the selection of tens of thousands of bao parents, the Early Childhood Development and Evaluation Center of Zhengda Fifth Affiliated Hospital won the second place in the list of "Henan People's Most Trusted Growth and Development Clinic".

Behind the honor reflects the profession of ZhengDa Fifth Affiliated Hospital in the field of pediatrics. The hospital pays attention to the early development of children aged 0 to 6 years old and establishes a child development and evaluation system. In 2019, it was approved by the Henan Provincial Engineering Research Center for Early Childhood Development and Evaluation, with the service tenet of "caring for health and growing up together", and conducting early growth and development assessment for children aged 0 to 6 years old.

In January 2021, the Adolescent Multidisciplinary Joint Outpatient Clinic of the Fifth Affiliated Hospital of Zhengda University was officially opened, and the center jointly established the China Children's Healthy Growth Alliance with the China National Health Association, the Henan Health Management Association and the Zhengzhou Health Education Association to focus on the healthy growth of children.

In fact, as early as September 2019, the Fifth Affiliated Hospital of Zhengda University was approved as the "Henan Provincial Engineering Research Center for Early Childhood Development and Evaluation" by the Henan Provincial Development and Reform Commission. The center is a special clinic area specially built for the monitoring of children's growth and development, and the multidisciplinary integration of perinatal health care, child health care, nutrition and feeding, endocrinology and metabolism, ophthalmology, oral cavity, ear, nose and throat, children's cerebral palsy and children's psychological behavior center guides the healthy growth of children.

Tang Youcai introduced that the center carries out healthy care for the whole growth cycle of children, opens a health clinic for infants and adolescent growth and development, and also opens a multidisciplinary joint clinic for adolescence to ensure that every child transitions from childhood and adolescence to adulthood, laying a good foundation for the future family and career. The center has established a child health management file, established a health file from birth, regular monitoring, regular physical examination, long-term follow-up, timely detection of growth deviations, and strive to achieve the maximum growth potential of each child.

Precise treatment of growth deviations

Over the years, Zhengda Fifth Affiliated Hospital has established a relatively perfect management system and work process in early childhood development and rare diseases, through long-term and dynamic monitoring, summarizing the outcome of different growth and development deviations and the effects of different intervention time and means, providing feasible operating procedures and solutions for various situations, reducing the occurrence of serious sequelae, saving medical resources for governments and medical institutions, and reducing economic burdens for families and society.

Tang Youcai introduced that the hospital carries out all-round and high-level health care for children, and common growth and development problems such as abnormal muscle tone, short stature, childhood obesity, and precocious puberty can be diagnosed and guided by experts with senior technical titles in relevant professions.

It is worth mentioning that the multidisciplinary joint outpatient clinic of adolescence opened by zhengda fifth affiliated hospital includes adolescent health care, abnormal puberty development and related endocrine diseases, adolescent psychological problems and adolescent physiological health problems. They will regularly hold lectures for adolescent students and carry out popular science education in adolescent medicine.

On November 17, 2020, the inauguration ceremony of the National Genetic Testing Technology Application Demonstration Center & Henan Rare Disease Genetic Testing and Precision Medicine Engineering Technology Research Center jointly held at the Shanghai New International Expo Center was successfully held. Tang Youcai introduced that the center is a provincial-level engineering technology research center approved for construction by relying on the Fifth Affiliated Hospital of Zheng University. His main responsibilities are to research rare disease gene detection and precision treatment, promote the application of gene sequencing in rare disease screening, and accelerate the popularization of gene sequencing in the field of rare diseases. It is committed to building a scientific research platform for genetic testing and precision treatment of rare diseases, striving to build the center into an incubator for the transformation of scientific and technological achievements in the field of rare diseases and precision medicine, a scientific research and development base with a high level, a high level and a high starting point inside and outside the United Nations, strengthening the output of scientific and technological achievements, enhancing the ability of scientific and technological innovation, and gradually making the engineering center a scientific research and innovation base with advanced experimental conditions and a high management level.

For the protection of children's liver experts actively carry out international academic exchanges

In 2018, At the invitation of Professor Jeffrey Teckman, director of the Cardinal Glennon Children's Medical Center at Saint Louis University and an internationally renowned expert in pediatric gastroenterology, Tang Youcai went to St. Louis University for academic exchanges on the research, diagnosis and treatment of children's alpha-1 antitrypsin deficiency.

While in the United States, he visited Professor Jeffrey Teckman's lab and had an in-depth discussion about the latest advances in alpha-1 antitrypsin deficiency (A1ATD). Alpha-1 antitrypsin deficiency is an autosomal recessive disorder that can lead to neonatal hepatitis, cirrhosis in infants and adults, and even hepatocellular carcinoma (HCC), which often requires liver transplant treatment, seriously affecting the health level of humans.

Alpha-1 antitrypsin deficiency is a recognized genetic disorder with a poor prognosis and a lack of effective treatment. Only inhibition or elimination of aggregation of the A1AT mutant Z protein can alleviate or treat liver disease associated with A1ATD. On the basis of the previous work, Professor Tang Youcai and Professor Jeffrey Teckman signed a continuing cooperation agreement to study the elimination of A1AT mutation Z protein accumulation by autophagy, improve the role of α1-antitrypsin deficiency, and provide a new idea for the clinical research and treatment of α1-antitrypsin deficiency liver disease.

At the end of 2018, the Science and Technology Department of Henan Province issued the Notice on Agreeing to Build the 2018 Henan Provincial International Joint Laboratory (Yu Kewai [2018] No. 19), relying on the "Henan Provincial Chronic Liver Injury International Joint Laboratory" built by the Fifth Affiliated Hospital of Zhengda University to obtain the approval of the Department of Science and Technology for project construction.

The approval of the construction of the international joint laboratory is inseparable from the long-term efforts of the experts of the Fifth Affiliated Hospital of Zheng University.

The "Henan Provincial International Joint Laboratory for Chronic Liver Injury" relies on the Fifth Affiliated Hospital of Zhengda University and is jointly established with Washington University in St. Louis and St. Louis University to cooperate in the study of metabolic syndrome-related chronic liver injury diseases. The head of the laboratory, Tang Youcai, has studied at Washington University in St. Louis and St. Louis University for nearly 10 years, and has long been engaged in the molecular mechanism of fatty liver combined with liver fibrosis, especially the systematic study of curcumin (curcumin) intervention in NAFLD-associated liver fibrosis. Since 2014, Tang Youcai and his team have conducted in-depth research on alpha-1 antitrypsin deficiency, aiming to complete the international joint project "The Role of Autophagy in Human Diseases", which provides an important platform for bringing together first-class scholars, building first-class disciplines and cultivating top-notch innovative talents.