*For medical professionals only
There is no distinction between good and bad, only suitable or unsuitable!
Doses vary greatly between different statins, 2 mg, 5 mg, 10 mg...
Therefore, many patients will ask: Can I eat a smaller dose of statin? Will the side effects be less?
What is the answer? Let's talk about it one by one
First, look at the lipid-lowering effect
First see if it can help you control your blood lipids.
1. Low-strength statins (LDL-C reduced by less than 30%), such as:
Fluvastatin 20-40 mg
Simvastatin 10 mg
Pravastatin 10-20 mg
Pitvastatin 1 mg
2. Moderate-intensity statins (30% to 50% reduction in LDL-C), such as:
Atorvastatin 10-20 mg
Rosuvastatin 5-10 mg
Simvastatin 20-40 mg
Pravastatin 40 mg
Pitvastatin 2-4 mg
3. High-strength statin (LDL-C decreased by more than 50%), such as:
Atorvastatin 40-80 mg
Rosuvastatin 20-40 mg
In the case of ensuring the lipid-lowering effect, let's take a look at:
Second, the dose of statin, the side effects are also small?
From the doctor's point of view, if the patient does not have special circumstances, the "side effects" of different statins are actually not much different.
From the patient's point of view, if you feel that it is safer to eat a smaller dose, then it is also possible to choose a small dose type of statin. (no special cases)
Why do doctors want me to take a larger dose?
Probably because you're better suited to eat that one. Like what:
1. Statin some liver, some kidney
The side effects of drugs are mostly related to their metabolic pathways, and the metabolism of statins goes through the liver, some through the kidneys, and some through the liver and kidneys. For patients with hepatic and renal insufficiency, such as liver diseases such as cirrhosis, doctors will choose statins metabolized by the kidneys more often; in patients with renal failure, they will give more priority to statins metabolized by the liver.
2. Some statins also affect blood sugar
At present, there are studies that show that pitvastatin and pravastatin have less effect on blood sugar and are more suitable for diabetic patients.
Atorvastatin, rosuvastatin, simvastatin, and fluvastatin are not conducive to blood sugar control.
■ Finally, two points are emphasized:
1. The risks of liver and kidney function damage, myopathy, cancer and emerging diabetes can be said to be insignificant compared with the cardiovascular benefits brought by the cardiovascular benefits. So don't worry too much about "side effects".
2. Statin has no good or bad, only suitable or inappropriate. If several statins are suitable for you, you can eat any one, and it is of course no problem to choose a small dose. But the key is that you are not "suitable".
Source of this article: Hatrim Heart Science
This article is written by Zhou Yang
Editor-in-Charge: Yuan Xueqing, Zhang Li
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