The Scarlets were scheduled to face the Bristol Bears at Ashton Gate on Saturday
The Welsh team is currently in coronavirus quarantine in Northern Ireland
When the omnicron variant was hit, they had already played two games in South Africa
On Saturday, scarlets lost the heineken Champions Cup billiards match at Ashton Gate against Bristol.
Tournament organisers European Professional Football Club (EPCR) have confirmed bristol to take five of Gallagher's Premier League clubs 28-0.
After the Crimson flew home from South Africa, which is on the British government's red list last week, 32 players are currently quarantined at a hotel in Belfast, where they were scheduled to play two joint rugby tournaments.
The Crimson (against Edinburgh in June) were forced to give up their match against Bristol
A statement from the organisers read: "EPCR has been informed from Scarlets that due to player welfare issues and the club's inability to safely field matchday teams, they are unable to complete the first round of the Heineken Champions Cup against Bristol The Bears are scheduled to take place at Ashton Gate on Saturday 11 December.
"As a result, the game in Pool B was cancelled and the Bristol Bears won the game at 28-0 at five match points under the rules of the game."
Following the discovery of a new variant of the coronavirus, South Africa imposed new travel restrictions.
Scarlett's trip to Bristol was scheduled the day after the end of the 10-day quarantine period, and they urged the EPCR to reconsider its stance on the rescheduling of European matches.
A club statement said: "After discussions between Scarlets management, coaches, players and medical and training staff, the overwhelming feeling is that choosing any of the 32 frontline squad members currently quarantined in quarantine would pose a physical risk. "Hotel outside Belfast.
"After returning from South Africa, the tour group has been in strict 10-day quarantine, confined to their own rooms every day, and have limited outdoor time to train en masse."
Wales centre-forward Jonathan Davis is one of the players currently in quarantine at Belfast
"The quarantine period will end on Friday 10 December – the day before the Bristol race.
'Currently, we have 14 players for Scarlets training at Parc y Scarlets – 7 senior players and 7 development players.
'We would like to thank the Ospres and Dragons for their help, but unfortunately we have not been able to put together a gameday team that can safely play against the Bears.