【Famous Doctor Business Card】
Zhu Demao is currently the Honorary Director of the Department of Pathology of Changsha Central Hospital (Changsha Central Hospital Affiliated to the University of South China) and the Director of the Housing Training Base.
Introduction: Engaged in clinical pathological diagnosis for nearly 40 years, he is currently a standing member of the Pathology Professional Committee of the Hunan Medical Association, a standing committee member and deputy leader of the cytology group of the Pathologist Branch of the Hunan Medical Doctor Association, a vice chairman of the Pathology Branch of the Hunan Health Service Association, an honorary chairman of the Pathology Professional Committee of the Changsha Medical Association, and an honorary director and expert group leader of the Changsha Pathological Quality Control Center. He has presided over and participated in the completion of 5 provincial scientific research projects, 6 municipal scientific research projects, and published more than 40 papers in domestic and foreign journals at all levels, including 5 SCI papers.
Professional Profile: He has studied from the top pathology masters in China at Peking University, Fudan University and Shanghai Jiaotong, and is good at surgical pathology and pathological diagnosis of difficult tumors. Every year, more than 10,000 cases of pathological diagnosis are re-examined and thousands of difficult pathological consultations are completed.
Dare to challenge: The golden period of the profession bravely picks up the heavy responsibility of discipline construction in municipal hospitals
In October 2011, 47-year-old Zhu Demao was introduced as the director of the pathology department of Changsha Central Hospital. At that time, he was already a top talent in the field of pathology in Hunan, the leader of the pathology department in the provincial hospital, and one of the few chief physicians of the pathology discipline in the province. Keenly aware of the thriving development vitality of Changsha Central Hospital, he resolutely chose to come to Changsha Central Hospital and provoked the burden of the construction and development of the pathology discipline of the Central Hospital. Zhu Demao said that at the beginning of the appointment, he had three major responsibilities: one was to continue to develop the pathology department that was compatible with the top three general hospitals; the second was to build an excellent talent echelon for the pathology department; and the third was to meet the needs of clinical precision medicine in the hospital.
From that year until april 2021, when he resigned from the administrative position of director of the Pathology Department due to physical reasons, Zhu Demao worked diligently in the post of director of the Pathology Department of Changsha Central Hospital for a full decade. In the second year after coming to the central hospital, he was elected as the chairman of the Changsha Pathological Society and the director of the Pathological Quality Control Center. Zhu Demao said that in today's precision medicine, pathological diagnosis plays the most important role. The level of the pathology department of the hospital is an important symbol of the overall diagnosis and treatment level of a hospital, without a high level of pathology it is impossible to build a high-level clinical department, and the development of the pathology department plays a pivotal role in the hospital. Pathological diagnosis provides a clear diagnosis of the disease from morphology to genetic change, determines the nature and prognosis of the disease, provides an important basis for clinicians to select treatment options and evaluate the prognosis, and provides an important basis for targeted therapy and immunotherapy for tumor patients. Therefore, pathological diagnosis is recognized as the "gold standard" for the diagnosis of diseases.
After arriving at the Pathology Department of Changsha Central Hospital, Zhu Demao actively applied to the hospital leaders for strong support in terms of room area, office environment, equipment and introduction of talents. According to the construction standards of the pathology department of the top three hospitals, the diagnosis room, the technical room, the cell room, the special staining room, the immunohistochemistry room, the molecular pathology room, the material extraction room, the archive room, etc. are set up, and the partition is clear and the layout is reasonable. The construction conditions of the general pattern allow him to "keep moving forward", establish and improve the department management and medical safety system and quality management system, and comprehensively speed up and improve the quality of the pathology department's business work. According to statistics, the Department of Pathology completes about 20,000 routine histopathological examinations, more than 50,000 cytology examinations, more than 2,000 frozen biopsy examinations, more than 18,000 immunohistochemical examinations, and more than 3,000 various consultation cases every year. In the evaluation of the top three hospitals, it was highly praised by the leaders of the Provincial Health Commission and the evaluation experts, and was called the benchmark for the construction of the pathology department in the province.
In terms of the construction of discipline talents, Zhu Demao has a clear idea and a clear goal, and he has made great efforts to cultivate talents and consolidate the talent foundation. At that time, the pathology department only had 7 staff members and 1 deputy senior title. Zhu Demao introduced talents in an eclectic manner, recruited talents, and successively introduced 2 deputy senior titles, 1 doctor, and more than 10 people recruiting masters. Take the lead in establishing sub-specialties in the province, establish their own sub-specialty development direction for each doctor in combination with their respective strengths, provide them with various opportunities for further study, participate in various academic conferences, and send 1-2 people to the pathology department of top hospitals in China every year to study and train, creating a strong learning atmosphere in the department. Take multiple measures to make good use of talents, so that people can make the best use of their talents.
Zhu Demao proudly said that under the current situation of only about 10,000 pathologists in the country, the talent echelon of the pathology department of Changsha Central Hospital ranks among the best in the province, and there are currently 4 chief physicians of pathology, 4 deputy senior pathologists, and the development direction of everyone sub-specialty is clear, all of which serve as members of the sub-specialized scientific group of the Hunan Provincial Pathological Society, and the pathological diagnosis ability is alone. The talent echelon is distributed in 12 major systems of respiratory pathology, obstetrics and gynecology pathology, endocrine pathology, lymphomatopoietic pathology, osteochondrogenic histopathology, gastrointestinal pathology, male reproductive and urinary system pathology, head and neck tumors, skin pathology, cytopathy, molecular pathology and autopsy, and neurohistology, providing strong support for the development of clinically related disciplines.
Professor Luo Haijun, the current director of the Department of Pathology, is good at cytopathology and chest disease diagnosis, Professor Jiang Shali, deputy director, is good at female reproductive tract and breast pathological diagnosis, Professor Wang Zhidang is good at lymphoma and osteochondrical tissue pathological diagnosis, Associate Professor Xie Jinyu is good at digestive pathological diagnosis, Associate Professor Zhao Yan is good at skin pathology diagnosis, and Associate Professor Zhou Huashan is good at urogenital pathological diagnosis. They have conducted academic exchanges and business lectures at provincial and municipal academic conferences for many times, and participate in various technical competitions in the province every year, among which young and middle-aged physicians Zhou Huashan, Liu Aifeng, Lian Yixiang, Xiang Wanting, etc. have achieved impressive results in provincial competitions, which has impressed their counterparts in the province.
In the display cabinet near the wall of the Pathology Department, there are stacks of honorary certificates: the first prize of the Provincial Pathology Routine Section, Immunohistochemical Quality Control, and Frozen Slice Competition; the National Winner Award of Paraffin Section of the Pathology Branch of the China Medical Equipment Commission in 2018; the Second and Third Prizes of the Pathological Map Competition for Young Physicians of the Provincial Pathological Society; the Special Prize, The First Prize and the Second Prize of the Pathology Map Competition of the Pathology Branch of the Hunan Medical Doctor Association in 2021... Due to the remarkable achievements of the department, Zhu Demao himself has also been commended many times and won the third class merit of the hospital.
Golden Eye of Fire: Accurately "Judging Cases" for Patients' Diseases in the Microscopic World
Entering the pathology department diagnosis room, the reporter saw Zhu Demao leading colleagues to discuss difficult pathology under a multi-headed microscope. There are more than ten microscopes on the connected desk, a group of doctors dressed in white are nervously busy, some are "finely crafted" under the microscope, some are carefully reviewing each "disease verdict", some are discussing cases with each other, the scene is tense but orderly, it can be seen that the pathology department under the leadership of Zhu Demao has a rigorous working attitude and a harmonious atmosphere in the department.
Zhu Demao introduced that in the pathology department, every report on patients will strictly implement the three-level review system. That is, after the primary doctor's report, it must be reviewed by two higher-level doctors to effectively ensure the accuracy of the report. So far, the pathology report issued by the Pathology Department of Changsha Central Hospital has not had a single case of misdiagnosis, and patients often borrow pathological slices to consult with higher-level hospitals, and patients reflect that higher-level hospitals fully recognize the diagnostic conclusions of the Pathology Department of Changsha Central Hospital: standardized, accurate and comprehensive.
Over the years, Zhu Demao has led a team of pathologists to diagnose a number of rare cases. For example, in 2012, the Department of Pathology issued the diagnosis report of the world's tenth rare case "fibroblast reticulocyte tumor"; in 2016, the Department of Pathology conducted a pathological examination of a 80-year-old woman with a uterine specimen and found that she had a rare intravascular large B-cell lymphoma, and only 8 cases were reported worldwide; in August this year, a 63-year-old female patient was sent for postoperative examination due to a left renal mass lesion, Zhu Demao consulted a large number of literature, and finally diagnosed a renal eosinophilic vacuole tumor. He introduced that the tumor is a new renal tumor category proposed by the International Urogenital Pathology Society in 2021, with unique molecular genetic characteristics, the domestic literature has not yet been reported, it belongs to the border lesion, postoperative only need to observe, do not have to radiotherapy chemotherapy and other anti-tumor treatment, thereby avoiding overtreatment, greatly reducing the patient's mental and economic burden. In October this year, Zhu Demao diagnosed a rare EWSR1-SMAD3-positive fibroblast tumor, he introduced that EWSR1-SMAD3-positive fibroblast tumor is the new type proposed in the latest WHO (2020) fifth edition of the cartilage and bone tumor classification, the domestic literature is rarely reported, is considered to be an invasive tumor, the treatment is mainly surgery, resection of impurities can cause postoperative recurrence, the significance for clinical treatment is very large. Every year, in the cases of consultation from the outside hospital, Zhu Demao repeatedly corrected the qualitative diagnosis of benign and malignant lesions.
Zhu Demao said that "reading accurate tablets" is the basic literacy of a pathologist, which requires pathologists to first have solid basic knowledge such as histology and anatomy, and then have the toughness and attitude of striving for excellence, while mastering the latest theories and diagnostic methods of pathological diagnosis. Zhu Demao, who has been engaged in pathological diagnosis for 40 years, although he has read countless films, he still treats every reading and diagnosis cautiously and carefully.
Zhu Demao introduced that the close connection between pathology and clinical is an important guarantee of a scientific and accurate pathology report, and in recent years, the department of pathology has strengthened communication with the clinic, and has held multidisciplinary consultations with oncology, obstetrics and gynecology, chest, endocrinology, etc. for many times, learning from each other, and greatly improving the level of diagnosis.
On Zhu Demao's desk was a microscope, a laptop, a stack of pathology diagnosis reports, and two thick piles of pathology books. He said that these books are pathology books updated in the past two years, and the laptop is used to consult the literature and take notes, and the new progress of pathological diagnosis and typical pathological cases will be sorted out and recorded according to the system classification, and then saved. His business learning has never stopped, recording more than 200,000 words of study notes. In 2017 and 2018, he studied in the Department of Pathology of Fudan University Obstetrics and Gynecology Hospital and the Department of Pathology of Ruijin Hospital of Shanghai Jiaotong University for half a year, where he studied under the top pathology masters in China and obtained a large amount of cutting-edge knowledge and advanced technology of pathology. Zhu Demao told reporters that as a medical frontier discipline, new theories, new progress, and new methods are constantly being updated, and pathologists, no matter how old they are, no matter how many years they have been working, need lifelong learning, keep pace with the times, and keep up with the pace of the times.
Keeping pace with the times: the development of molecular pathology has made the "gold standard" gold content higher
In recent years, with the development of medicine and the requirements of precision treatment, the development of new technologies and new methods is particularly important. Zhu Demao introduced that at present, the fifth edition of the new classification of tumors has introduced genetic gene changes, and many unrecognized tumors in the past have obtained new names through genetic analysis. The development of molecular pathology is an indispensable means of modern hospitals. At present, precision medicine is developing rapidly, and accurate pathological diagnosis can help clinicians better judge the benign and malignant nature of tumors, the classification and grading of malignant tumors, etc.; by finding "targets", that is, specific gene mutations or genomes in cancer cells, targeted drugs and dosages that can provide personalized treatment for patients, as well as tumor prognosis and prevention, play an important role. This gives a new connotation to pathology, so that the "gold standard" of pathology has a higher gold content.
Zhu Demao introduced that the pathology department of the central hospital has carried out a generation of sequencing and other gene detection technologies, carried out multiple molecular pathology projects such as lung cancer polygenic detection and tumor immunotherapy, obtained 15 genetic testing ability verification room inter-quality assessments, and obtained national qualification certificates. Wang Guihua, director of the Oncology Department of Changsha Central Hospital, said that targeted treatment of tumors is the main means of personalized treatment, and effective targeted therapy must first have accurate molecular pathological diagnosis. The pathology department led by Director Zhu Demao can carry out targeted detection of relevant tumor gene mutation sites by means of isolation and extraction of pathological specimens, probe labeling, fluorescence quantitative PCR detection, sequencing, etc., to achieve the purpose of precision treatment, which is a very fortunate thing for tumor patients.
Zhu Demao said that as an affiliated hospital of the University of South China, in addition to improving the overall diagnosis level of the department, scientific research and teaching are also going hand in hand. In the past five years, the department has undertaken and completed 17 various projects at all levels, including 1 at the national level, 6 at the provincial level and 10 at the municipal level. He has published more than 30 papers in domestic and foreign journals, including 6 in SCI and 26 in core journals. Zhu Demao said that ten years have passed in a flash, it is the central hospital that has given me a good platform to improve myself and show myself, and the achievements made in the development of the department to today are the results of the strong support of hospital leaders, the cooperation of various departments, and the joint efforts of all colleagues. It is expected that the pathology department in changsha city center will accumulate and start a new journey.