Ethyl cyanoacetate, chemical formula c5h7no2, is an organic substance. Ethyl cyanoacetate has a colorless or pale yellowish liquid appearance, aromatic odor, and toxicity. Ethyl cyanoacetate is soluble in ammonia water, strong alkali aqueous solution, can be miscible with ethanol, ether, slightly soluble in water, aqueous solution is alkaline. Ethyl cyanoacetate is combustible, and when burned, heated, and met with water, it will release toxic cyanide gas.
The preparation process of ethyl cyanoacetate mainly includes: first, with cyanoacetic acid and ethanol as the main raw material, adding sulfuric acid as a catalyst, placing it in the reactor, reacting under low temperature conditions, and then making the finished product by washing, drying, distillation and other processes; second, taking chloroacetic acid and ethanol as the main raw materials, after esterification reaction, and then cyanidation reaction with sodium cyanide, and then through filtration, distillation, rectification and other processes to obtain the finished product; third, chloroacetic acid as the main raw material, neutralizing with soda ash, successively adding sodium cyanide and hydrochloric acid for reaction, Finally, the esterification reaction is carried out with ethanol, and then the finished product is prepared by filtration, distillation, rectification and other processes.
According to the "2021-2025 China Ethyl Cyanoacetate Industry Brand Market Structure and Competitor Field Investigation Report" released by the New Thinking Industry Research Center, ethyl cyanatoacetate can be used as an organic synthetic raw material, pharmaceutical intermediate, and dye intermediate. As an organic synthesis raw material, ethyl cyanoacetate can be synthesized into esters, acids, amide compounds, for example, can be reacted with ethanol to form diethyl malonate; can react with bromine to form ethyl bromocyanoacetate; can occur with ammonia to generate cyanoacetamide; can also be associated with formaldehyde, acetaldehyde, ketones polycondensation reaction; can also produce 502 adhesive.
As a dye intermediate, ethyl cyanoacetate can be used to produce oil-soluble coloring agents for use in the field of plastic film manufacturing. As a pharmaceutical intermediate, ethyl cyanoacetate can react with methoxyacetylacetone and ammonia water, and obtain vitamin B6 by nitrification, chlorination, catalytic hydrogenation, diazotization, hydrolysis, salting and other processes; it can be reacted with ethanol, and then 2-amino-4,6-dimethoxypyrimidine intermediates are prepared by multi-channel process, which can be used to prepare sulfonylurea herbicides, insecticides fipronil, vitamin B; can also be used for the synthesis of caffeine.
Tiande Chemical Holdings Co., Ltd. is one of the main suppliers of ethyl cyanoacetate in China, the company is a professional manufacturer of fine chemical products, ethyl cyanoacetate is one of its main products. According to the company's annual report data, in 2020, the operating income of Tiande Chemical was 1.359 billion yuan, down 1.6% from 2019; the net profit attributable to the mother was 94.821 million yuan, up 340.9% from 2019.
New thinking industry analysts said that ethyl cyanoacetate is an important raw material for fine chemicals, can be applied in the chemical, dye, pharmaceutical and other production fields, since the 21st century, with the expansion of the application field, downstream market demand growth, China's ethyl cyanoacetate market size continues to expand. In China's ethyl cyanoacetate industry, the number of large enterprises is small, and the number of small and medium-sized enterprises is large. China's chemical industry is developing in the direction of integration and collectivization, and ethyl cyanoacetate enterprises also need to conform to the development trend, improve in the direction of scale, and improve core competitiveness.