He Liping, chief reporter of The Paper
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
Tian Mei was the only young man among the guests at this forum. Tian Mei, a recipient of the National Science Foundation for Outstanding Young Scholars, joined Fudan full-time this year, and was previously the former deputy director of the Zhejiang University Medical Center and the director of the Zhejiang Provincial Key Laboratory of Medical Molecular Imaging. On December 24, 2020, the list of presidents of the World Molecular Imaging Society was officially announced, and Tian Mei was elected as the president of the World Molecular Imaging Society, which is the first time that a Chinese expert has served as the president of the World Molecular Imaging Society.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
Tian Mei was the only young man among the guests at this forum. Tian Mei, a recipient of the National Science Foundation for Outstanding Young Scholars, joined Fudan full-time this year, and was previously the former deputy director of the Zhejiang University Medical Center and the director of the Zhejiang Provincial Key Laboratory of Medical Molecular Imaging. On December 24, 2020, the list of presidents of the World Molecular Imaging Society was officially announced, and Tian Mei was elected as the president of the World Molecular Imaging Society, which is the first time that a Chinese expert has served as the president of the World Molecular Imaging Society.
It is worth mentioning that as the "oldest age" at this centenarian forum, Nell also expressed his own perception of "getting old". After retirement, Nell is still conducting research work, and only by solving and delaying aging and the health problems it brings can he better continue his research and prolong his life as a researcher.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
Tian Mei was the only young man among the guests at this forum. Tian Mei, a recipient of the National Science Foundation for Outstanding Young Scholars, joined Fudan full-time this year, and was previously the former deputy director of the Zhejiang University Medical Center and the director of the Zhejiang Provincial Key Laboratory of Medical Molecular Imaging. On December 24, 2020, the list of presidents of the World Molecular Imaging Society was officially announced, and Tian Mei was elected as the president of the World Molecular Imaging Society, which is the first time that a Chinese expert has served as the president of the World Molecular Imaging Society.
It is worth mentioning that as the "oldest age" at this centenarian forum, Nell also expressed his own perception of "getting old". After retirement, Nell is still conducting research work, and only by solving and delaying aging and the health problems it brings can he better continue his research and prolong his life as a researcher.
Professor Erwin Nell, 77, winner of the 1991 Nobel Prize in Physiology or Medicine.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
Tian Mei was the only young man among the guests at this forum. Tian Mei, a recipient of the National Science Foundation for Outstanding Young Scholars, joined Fudan full-time this year, and was previously the former deputy director of the Zhejiang University Medical Center and the director of the Zhejiang Provincial Key Laboratory of Medical Molecular Imaging. On December 24, 2020, the list of presidents of the World Molecular Imaging Society was officially announced, and Tian Mei was elected as the president of the World Molecular Imaging Society, which is the first time that a Chinese expert has served as the president of the World Molecular Imaging Society.
It is worth mentioning that as the "oldest age" at this centenarian forum, Nell also expressed his own perception of "getting old". After retirement, Nell is still conducting research work, and only by solving and delaying aging and the health problems it brings can he better continue his research and prolong his life as a researcher.
Professor Erwin Nell, 77, winner of the 1991 Nobel Prize in Physiology or Medicine.
"Now, my workload has also been reduced a lot, but I believe there are still many ways to keep us active," he said. Staying active is very important, and not thinking is equivalent to retiring mentally. ”
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
Tian Mei was the only young man among the guests at this forum. Tian Mei, a recipient of the National Science Foundation for Outstanding Young Scholars, joined Fudan full-time this year, and was previously the former deputy director of the Zhejiang University Medical Center and the director of the Zhejiang Provincial Key Laboratory of Medical Molecular Imaging. On December 24, 2020, the list of presidents of the World Molecular Imaging Society was officially announced, and Tian Mei was elected as the president of the World Molecular Imaging Society, which is the first time that a Chinese expert has served as the president of the World Molecular Imaging Society.
It is worth mentioning that as the "oldest age" at this centenarian forum, Nell also expressed his own perception of "getting old". After retirement, Nell is still conducting research work, and only by solving and delaying aging and the health problems it brings can he better continue his research and prolong his life as a researcher.
Professor Erwin Nell, 77, winner of the 1991 Nobel Prize in Physiology or Medicine.
"Now, my workload has also been reduced a lot, but I believe there are still many ways to keep us active," he said. Staying active is very important, and not thinking is equivalent to retiring mentally. ”
Hartl, who has yet to win the Nobel Prize, quipped to Nell, "But some researchers say that the average Life Expectancy of Nobel Laureates is longer than the average person, so your scientific career may be longer than other scientists." ”
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
Tian Mei was the only young man among the guests at this forum. Tian Mei, a recipient of the National Science Foundation for Outstanding Young Scholars, joined Fudan full-time this year, and was previously the former deputy director of the Zhejiang University Medical Center and the director of the Zhejiang Provincial Key Laboratory of Medical Molecular Imaging. On December 24, 2020, the list of presidents of the World Molecular Imaging Society was officially announced, and Tian Mei was elected as the president of the World Molecular Imaging Society, which is the first time that a Chinese expert has served as the president of the World Molecular Imaging Society.
It is worth mentioning that as the "oldest age" at this centenarian forum, Nell also expressed his own perception of "getting old". After retirement, Nell is still conducting research work, and only by solving and delaying aging and the health problems it brings can he better continue his research and prolong his life as a researcher.
Professor Erwin Nell, 77, winner of the 1991 Nobel Prize in Physiology or Medicine.
"Now, my workload has also been reduced a lot, but I believe there are still many ways to keep us active," he said. Staying active is very important, and not thinking is equivalent to retiring mentally. ”
Hartl, who has yet to win the Nobel Prize, quipped to Nell, "But some researchers say that the average Life Expectancy of Nobel Laureates is longer than the average person, so your scientific career may be longer than other scientists." ”
"Maybe it's because Nobel laureates eat more chocolate than others?" Has anyone studied whether chocolate is the cause of health? Nell successfully "picked up the stem" and said that the mechanism of human aging is indeed affected by many factors, and its mysteries have not been fully uncovered.
He Liping, chief reporter of The Paper
Why do humans age? Why don't humans survive forever? Why do pets always leave us first? The lifespan of mammals such as cats and dogs varies greatly from that of humans? Professor Franz-Ulrich Hartl, winner of the 2011 Lasker Prize for Basic Medical Research, threw out this question at the Centenary Forum for the World's Top Scientists on November 2.
Hartle, 64, and Professor Erwin Nell, the 77-year-old winner of the 1991 Nobel Prize in Physiology or Medicine, simply laughed at himself on the other end of the screen, "I'm not a young scientist anymore, and I'm here today on behalf of old scientists." ”
How do these apparently aging scientists see aging? How do you get along with your ageing self? Professor Michael Hall (68), winner of the 2017 Lasker Prize for Basic Medical Research, answered this question from the perspective of evolutionary stress, when 100 years ago, when people did not have competitive survival pressures, people's life expectancy was mostly at a younger age.
Today, he argues, we need to live longer, and not only is procreation a pressure, but the pressure to raise the next generation and the next generation may also make people live longer. Survival pressures vary between species.
Professor Hans Clives (64), winner of the 2013 Breakthrough Prize in Life Sciences, boils it down to a "planetary choice": "If humans or most of the animals don't end up disappearing, the planet is too crowded." ”
In fact, despite the many health burdens that humans have, scientists mostly believe that the "reversibility" of aging is the most difficult, and perhaps interventions to prevent and slow down the process are more realistic. Scientists first need to know how wrinkles, silver hair, and sluggishness, the daily signs of aging, are present at the molecular level.
Hartl explores the possibilities of healthy aging by starting with the folding of proteins. Most proteins need to be folded to function, and miscachment and loss of integrity of proteins can predict aging in the human body and be associated with neurodegenerative diseases such as Parkinson's disease. "Our research direction is to improve the protein to achieve a steady state, so that the folding of the protein is also balanced."
Hall talked about metabolism. mTOR is a substance that controls the body's metabolism and is also a nutrient. On the one hand, mTOR can control cell metabolism, such as cell growth and apoptosis; on the other hand, mTOR also affects the synthesis of proteins and lipids. As a result, mTOR influences complex signal networks and provides an effective nutrient perception signaling pathway, which is associated with numerous diseases. Its research hopes to affect human longevity by controlling mTOR.
Cleves talked about stem cells that are hot in the field of aging research. Can it be possible to "replace" or "repair" aging organs through stem cell transplantation? Cleves and his research team are working on this, growing stem cells in a laboratory setting, growing new organs, and then transplanting them into the human body. This vision has yet to be more validated and is expensive. He also mentioned that in the future, the relevant methods may be applied in more fields, "when cancer cells appear in the human body, we may also be able to treat them through this method." ”
Professor Tian Mei of the Institute of Human Phenotype Group of Fudan University conducted aging detection through molecular imaging technology. "Aging is a process, and there are many markers in this process, some of which manifest as instability in gene expression." Tian Mei is engaged in genotyping research, which visualizes aging and disease through imaging technology, and different imaging methods are suitable for different methods of detection. RCC2, for example, can help detect a patient's IQ, EQ, through this test can make a judgment on their cognitive ability.
Tian Mei was the only young man among the guests at this forum. Tian Mei, a recipient of the National Science Foundation for Outstanding Young Scholars, joined Fudan full-time this year, and was previously the former deputy director of the Zhejiang University Medical Center and the director of the Zhejiang Provincial Key Laboratory of Medical Molecular Imaging. On December 24, 2020, the list of presidents of the World Molecular Imaging Society was officially announced, and Tian Mei was elected as the president of the World Molecular Imaging Society, which is the first time that a Chinese expert has served as the president of the World Molecular Imaging Society.
It is worth mentioning that as the "oldest age" at this centenarian forum, Nell also expressed his own perception of "getting old". After retirement, Nell is still conducting research work, and only by solving and delaying aging and the health problems it brings can he better continue his research and prolong his life as a researcher.
Professor Erwin Nell, 77, winner of the 1991 Nobel Prize in Physiology or Medicine.
"Now, my workload has also been reduced a lot, but I believe there are still many ways to keep us active," he said. Staying active is very important, and not thinking is equivalent to retiring mentally. ”
Hartl, who has yet to win the Nobel Prize, quipped to Nell, "But some researchers say that the average Life Expectancy of Nobel Laureates is longer than the average person, so your scientific career may be longer than other scientists." ”
"Maybe it's because Nobel laureates eat more chocolate than others?" Has anyone studied whether chocolate is the cause of health? Nell successfully "picked up the stem" and said that the mechanism of human aging is indeed affected by many factors, and its mysteries have not been fully uncovered.
Editor-in-Charge: Li Yuequn
![70 days have passed in 2022, and these ordinary people are more worthy of a hot search than stars[fig]](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=)