Content overview
i. Clinical use of aspartases
ii. The cause of pancreatitis that is easy to cause when using such drugs
iii. What are the dietary requirements and how long the dietary principles should be adhered to
<h1 class="pgc-h-arrow-right" data-track="30" >, the use of asparticid drugs in the clinic</h1>
The so-called asparagine drugs mainly refer to: pepatase PEG-Asp (long-acting), levoaparaginase L-ASP (short-acting)
As the main agent in the combination chemotherapy regimen of acute lymphoblastic leukemia in children and malignant lymphoma in adults, its remission rate and long-term disease-free survival rate can be significantly improved;
The chemotherapy regimen VDLP (vincristine, daunorubicin, asparaginase, prednisone) is the first-line treatment regimen for adult acute lymphoblastic leukemia;
Location structure diagram of the pancreas
Function of the pancreas: endocrine function and exocrine function
Endocrine dysfunction: It can cause our common diabetes
Exocrine dysfunction: causes digestive function, or abnormalities in the pancreas itself
Acute pancreatitis: it is the digestive enzyme secreted by the pancreas, which digests itself! That is, you have digested your own pancreas, damaged yourself, destroyed yourself, and produced inflammation.
Mechanism of action:
It may be due to drug damage to the pancreatic tissue, promote the secretion of pancreatic juice and pancreatic enzymes, increase the viscosity of the pancreatic fluid or poor excretion of the pancreatic duct, and the pancreas begins to digest and damage itself, self-destruction, and inflammation
(Pancreatic Inner Monologue: Don't let me digest food, I digest myself in turn!) It's a fierce pancreas! ）
<h1 class="pgc-h-arrow-right" data-track="31" > second, common causes of pancreatitis during the use of asparticles</h1>
1. The diet is greasy
2. Overeating
3. High-sugar diet
4. Infection
<h1 class="pgc-h-arrow-right" data-track="61" >3, [aspartase drug therapy and dietary requirements].</h1>
1. Low-fat diet: prevent complications
Total calories: 20-30 kcal/day, supplemented with enteral nutrition preparations if necessary
Protein: accounting for 10-15% of the energy ratio, the child can be appropriately improved, usually normal intake of protein can be
Fat: less than 20% of the energy (including animal and vegetable fat content and cooking oil fat content)
2. Low-sugar diet: prevent complications
Staple food: eat in moderation, meal combination, strictly ensure and control intake and record (can not not eat, can not eat more)
Dairy products: after medication, it is easy to cause lactose intolerance diarrhea, milk needs to be boiled, and the content of purine in yogurt is relatively higher than that of milk, and the consent of the attending doctor is obtained before consumption
Fruit: Eat as standard for hematopoietic stem cell transplantation, about 200 grams per day
Not recommended: Refined sugar and too much sugary pastries, desserts, drinks
3. Suggested ingredients
Staple foods: rice, noodles, beans
Oils and fats: olive oil, soybean oil, peanut oil and other vegetable oils
Milk, eggs: pure milk (boiled), boiled quail eggs, eggs, duck eggs, egg soup, etc. (boiled eggs do not eat egg yolks)
Meat: fresh lean pork, white meat (chicken, duck, pigeon, fish, shrimp, etc. peeled and shelled)
Vegetables: Fresh vegetables washed and cooked (except leeks)
Fruits: apples, oranges, etc
Condiments: soy sauce, vinegar, salt, green onion, ginger, garlic, etc
4. Meal frequency and cooking method
Eat less and eat more: Keep seven or eight minutes full of food each time, and adjust the number of times you eat per day to ensure nutrition
Suggested cooking method: boiling, steaming, sautéing, simmering, stewing, etc
5. Dietary contraindications:
(1) Sugar, hard: pure sugar and high sugar desserts, nuts, bones, fish bones, animal offal, fatty meat, broth
(2) People with diarrhea: fasting whole grains, high-fiber foods, nuts, beans
(3) Cooking method: frying, frying, baking
(4) Contraindicated ingredients:
Vegetables: leeks
Fruits: Do not eat peaches, mangoes, grapefruit, etc
Meat: animal offal, broth, skin, fatty meat, etc
Seasoning: Do not eat dry ingredients and pickled products that have been stored for too long to avoid bacteria causing infections, such as peppercorns, large ingredients, bean paste, curd milk, cinnamon, fragrant leaves, etc
6. Asparagus drug diet - execution time
L-ASP (short-acting):
Drug metabolism: relatively short time, half-life of 7 hours
Duration of diet: 2 days before treatment to 1 week after discontinuation
Pexpaxase PEG-Asp (long-acting):
Drug metabolism: the time is relatively long, the half-life is 1 week, and the duration is 3 weeks
Duration of diet: 2 days before treatment to 3 weeks after discontinuation
<h1 class="pgc-h-arrow-right" data-track="111" > [Winter Diet summary].</h1>
Nutritional Support Pathway: Eating orally to ensure proper functioning of the gastrointestinal tract
Dietary ingredients: low-fat, low-sugar natural diet
Loss of appetite: Eat less and eat more meals to ensure the body's energy support
Nutritional deficiencies: increase enteral nutrition preparations, save protein
Induce pancreatitis: pay attention to diet in advance to prevent complications
Hyperglycemia: control staple food intake, fasting pure sugar foods (desserts, beverages, etc.)
High uric acid: forbidden broth, leeks, animal offal (stew only eat meat, do not drink soup)
Hypoproteinemia: Total calories are guaranteed and whey protein powder is increased in an appropriate amount
Hypocalcemia: plain yogurt, green leafy vegetables
Diarrhea: stop diarrhea in time, eat less residue food
Patients share true stories ~ let you step on the pit less ~
[My anti-cancer story] I was 25 years old when I was sick, and all the rejection made me encounter.