NRR Hot Review Article: Mechanism of Microglia in Neurological Disorders

In the field of neurological diseases, microglia, as a key innate immune cell, have received increasing attention to their mechanism of action.

In recent years, studies have found that microglia play a complex and important role in neuroinflammation, neurodegenerative diseases, and nerve repair. Especially in diseases such as depression, Alzheimer's disease, etc.,

Microglia are involved in the occurrence and progression of diseases by activating inflammatory pathways such as NLRP3 inflammasomes.

In addition, environmental factors and lifestyle changes, such as air pollution and chronic stress, may also lead to neurological inflammation and cognitive impairment by affecting the function of microglia.

In-depth exploration of the specific mechanism of action of microglia in neurological diseases and how to treat related diseases by regulating their function has become a hot topic in current research.

To this end, 3 review articles on the mechanism of microglia in neurological diseases published by scholars in this journal from 2023 to 2024 are selected and recommended for readers.

(1) Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

Therapeutic strategies for microglial NLRP3 inflammasomes mediating neuroinflammation and depression

Qiuqin Han 1, Wenhui Li 1, Peiqing Chen 1, Lijuan Wang 1, Xiwen Bao 1, Renyan Huang 2, Guobin Liu 2, Xiaorong Chen 3

1 Department of Scientific Research, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

2 Department of Traditional Chinese Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

3 Department of Physiology, Laboratory of Neurodegenerative Diseases, Changzhi Medical College, Changzhi, Shanxi Province, China.

Cite this article:

Han Q, Li W, Chen P, Wang L, Bao X, Huang R, Liu G, Chen X. Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression. Neural Regen Res. 2024; 19(9):1890-1898.

Body Links:

https://journals.lww.com/nrronline/fulltext/2024/09000/microglial_nlrp3_inflammasome_mediated.16.aspx

(2) Interplay between microglia and environmental risk factors in Alzheimer's disease

Interactions between microglia and environmental risk factors for Alzheimer's disease

Miaoping Zhang, Chunmei Liang, Xiongjin Chen, Yujie Cai, Lili Cui

Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China.

Cite this article:

Zhang M, Liang C, Chen X, Cai Y, Cui L. Interplay between microglia and environmental risk factors in Alzheimer's disease. Neural Regen Res. 2024; 19(8):1718-1727.

Body Links:

https://journals.lww.com/nrronline/fulltext/2024/08000/interplay_between_microglia_and_environmental_risk.24.aspx

(3) Resident immune responses to spinal cord injury: role of astrocytes and microglia

Spinal cord injury resident immune response: effects of astrocytes and microglia

Sydney Brockie 1 2, Cindy Zhou 1 2, Michael G Fehlings 1 2 3

1 Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

2 Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

3 Division of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Cite this article:

Brockie S, Zhou C, Fehlings MG. Resident immune responses to spinal cord injury: role of astrocytes and microglia. Neural Regen Res. 2024; 19(8):1678-1685.

Body Links:

https://journals.lww.com/nrronline/fulltext/2024/08000/resident_immune_responses_to_spinal_co