NRR熱點綜述文章：小膠質細胞在神經系統疾病中的作用機制

在神經系統疾病的研究領域，小膠質細胞作為一種關鍵的固有免疫細胞，其作用機制日益受到重視。

近年來，研究發現小膠質細胞在神經發炎、神經退行性疾病以及神經修複過程中扮演着複雜而重要的角色。特别是在抑郁症、阿爾茨海默病等疾病中，

小膠質細胞通過激活NLRP3發炎小體等發炎途徑，參與疾病的發生和發展。

此外，環境因素和生活方式的改變，如空氣污染和慢性壓力等，也可能通過影響小膠質細胞的功能，導緻神經系統發炎和認知損傷。

深入探讨小膠質細胞在神經系統疾病中的具體作用機制，以及如何通過調節其功能來治療相關疾病，已成為目前研究的熱點話題。

為此，選擇本刊學者2023-2024年發表的小膠質細胞在神經系統疾病中作用機制的相關綜述文章3篇，推薦讀者閱讀。

(1) Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

小膠質細胞 NLRP3 炎性體介導神經發炎與抑郁症的治療政策

Qiuqin Han 1, Wenhui Li 1, Peiqing Chen 1, Lijuan Wang 1, Xiwen Bao 1, Renyan Huang 2, Guobin Liu 2, Xiaorong Chen 3

1 Department of Scientific Research, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

2 Department of Traditional Chinese Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

3 Department of Physiology, Laboratory of Neurodegenerative Diseases, Changzhi Medical College, Changzhi, Shanxi Province, China.

引用本文：

Han Q, Li W, Chen P, Wang L, Bao X, Huang R, Liu G, Chen X. Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression. Neural Regen Res. 2024;19(9):1890-1898.

正文連結：

https://journals.lww.com/nrronline/fulltext/2024/09000/microglial_nlrp3_inflammasome_mediated.16.aspx

(2) Interplay between microglia and environmental risk factors in Alzheimer's disease

小膠質細胞與阿爾茨海默病環境風險因素之間的互作

Miaoping Zhang, Chunmei Liang, Xiongjin Chen, Yujie Cai, Lili Cui

Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China.

引用本文：

Zhang M, Liang C, Chen X, Cai Y, Cui L. Interplay between microglia and environmental risk factors in Alzheimer's disease. Neural Regen Res. 2024;19(8):1718-1727.

正文連結：

https://journals.lww.com/nrronline/fulltext/2024/08000/interplay_between_microglia_and_environmental_risk.24.aspx

(3) Resident immune responses to spinal cord injury: role of astrocytes and microglia

脊髓損傷常駐免疫反應：星形膠質細胞和小膠質細胞的效應

Sydney Brockie 1 2, Cindy Zhou 1 2, Michael G Fehlings 1 2 3

1 Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

2 Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

3 Division of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.

引用本文：

Brockie S, Zhou C, Fehlings MG. Resident immune responses to spinal cord injury: role of astrocytes and microglia. Neural Regen Res. 2024;19(8):1678-1685.

正文連結：

https://journals.lww.com/nrronline/fulltext/2024/08000/resident_immune_responses_to_spinal_co