At present, the lipid-lowering injections that have been included in the medical insurance in mainland China are the PCSK9 inhibitors enoxumab and alixirumab, which are given once every 1-2 weeks, and the price of a single injection is 200-300 yuan.
These two lipid-lowering injections reduce cholesterol by inhibiting the binding of PCSK9 to low-density lipoprotein receptor (LDLR) and giving full play to the effect of low-density lipoprotein receptors, which is simply the "cholesterol scavenger" in the body, and can reduce cholesterol by more than 50%.
Lipid-lowering injections are not suitable for all people with high blood lipids, and there are often five misunderstandings.
First, 30% of the cholesterol in our body comes from gastrointestinal absorption, 70% comes from the synthesis of cholesterol by the liver, statins are to reduce the synthesis of cholesterol in the liver, and the average lipid reduction range is about 30%, which can meet the treatment needs of most patients with hyperlipidemia.
Second, as mentioned earlier, lipid-lowering injection evolocumab and aliximumab are cholesterol scavengers in the body, which do not affect the intestinal absorption and liver synthesis of cholesterol, and in a sense, they are symptomatic but not curative. If we blindly add or replace lipid-lowering injections when we use statin drugs to smoothly control blood lipids, it is undoubtedly a wrong approach.
3. When our blood lipids are elevated, we should first consult a specialist doctor to formulate a lipid-lowering goal; simple high blood lipids, low-density lipoprotein cholesterol is reduced to 3.4mmol/L, the lipid-lowering target of the three-high people is below 2.6, and those with arteriosclerosis stenosis and coronary heart disease should be controlled below 1.8mmol/L, and the indicators of people who have had myocardial infarction and cerebral infarction should be reduced to below 1.4.
High cholesterol though can lead to atherosclerotic plaques, stenosis. Cholesterol plays an important role in energy metabolism in the body, and the lower the better. Therefore, it is obviously wrong to deliberately pursue low indicators and choose lipid-lowering injections.
Fourth, some friends may think that lipid-lowering injection is an imported original drug, the price is high, the side effects must be small, in fact, there are obvious side effects, such as rash, eczema, erythema and other allergic reactions, injection site bruising, pain, redness, swelling, infection, may also cause nasopharyngitis, upper respiratory tract infection, muscle pain, muscle spasms, dizziness, headache, vomiting, fatigue, blood pressure increase and other adverse reactions.
Fifth, lipid-lowering injections are injected once every half a month, which is very convenient and has strong medication compliance, but it is not suitable for most patients with hyperlipidemia, and is only suitable for two types of people, one is familial hereditary hyperlipidemia, which often has a poor effect of oral drugs to control blood lipids, and the other is the high-risk group of cardiovascular events, which needs to reduce blood lipids to a lower target level as soon as possible, and when oral drugs are difficult to meet the standard, consider taking lipid-lowering injections.
The above content is for reference only, if you want to use lipid-lowering injections, you must consult a specialist, do not buy it yourself, inject it at home, and have adverse consequences.
Thanks for reading, please like, follow, and forward to the circle of friends, thank you again, goodbye!