This issue of "Poison Theory" forwards a handwriting note of Feng Bingzhe, a senior inspector at Jinan Borui Medical Laboratory, and records 6 cases of poisoning of children who have mistakenly taken diet pills in just over 2 months, so daily and so distressing.
The heart of beauty is shared by everyone.
In the hot summer, it is time to lose weight.
I would like to use this article to warn the beauty lovers who are struggling to lose weight,
Diet pills should be chosen correctly, and they must be put in place!
——Feng Bingzhe
Date June 24
I'm on duty tonight, at 2 a.m.
An hour ago, the laboratory received an urgent test blood sample from the hospital, a 7-year-old girl accidentally ate 4 "fat-reducing chocolate", 4 or 5 hours later, the child cried chest pain, nausea and wanted to vomit, the family rushed her to the hospital, the heart rate when sent to the hospital was 100 times per minute.
According to the experience of doing diet pill testing before, my first thought was illegal Western medicine addition, from the symptom description, I decided to start from the stimulant for computer detection analysis, and sure enough, the concentration of sibutramine was detected in the blood as 86ng/mL, which is a relatively high value in similar cases recently. I fed back the results to the doctor, who began to treat the child symptomatically.
At this time, the sky is not yet dark, the window is still dark, the laboratory only has the sound of machine current, I feel an unspeakable heaviness and anxiety, and even a kind of anger: in just two months, I have personally tested about the illegal ingredient sibutramine diet pills hurt children there are as many as 6 cases, every morning when the technical shift, my colleagues in Beijing, Shijiazhuang, Guangdong also continue to report that there are cases of children mistakenly eating fat-reducing chocolate, fat-reducing shakes and other drug poisoning cases.
The state has banned sibutramine for 11 years, and there have been so many cases of sibutramine poisoning recently detected, and professional vigilance tells me: sibutramine, the "weight loss killer", has reappeared in the jianghu!
Popular science: sibutramine
This is a promotional picture of fat-reducing chocolate circulating in the circle of friends
Sibutramine is a mixed 5-HT and norepinephrine reuptake inhibitor that inhibits appetite by blocking the reuptake of norepinephrine and 5-HT by blocking the neuromediator, while increasing the use of glucose by adipose tissue and thermogenesis, increasing energy expenditure, and reducing body weight.
Sibutramine was first used in the treatment of depression, but in clinical applications, it was found that its weight reduction effect was significantly better than the antidepressant effect, so it was developed as a diet pill and was approved for marketing in the United States in 1997 and approved for marketing in China in 2000.
However, with the wide application of sibutramine, a 6-year-long SCOUT clinical trial showed that the average weight loss of long-term use is limited, but its side effects are very large, ranging from thirst, palpitation, insomnia, and neurological damage and psychiatric diseases, resulting in a significant increase in the risk of cardiovascular and cerebrovascular events and even death, and the risk of weight loss treatment is significantly greater than the clinical benefit.
In 2010, sibutramine was withdrawn from the international and domestic markets. On October 30, 2010, China officially stopped the production, sales and use of all preparations and APIs containing sibutramine, such as Qumei and Nometing.
What worries me even more is that in the poison detection cases received every day, most of the cases involving children are mistakenly ingested and misused, are parents now so careless? Look at the following real cases, are you afraid of not being able to get started?
Date June 18
Patient Name: **Qi Age: 2 years old
Symptoms: At more than 19:00 on the evening of June 16, the child mistakenly took four fat-reducing chocolates, sent to the local hospital for gastric lavage at 20:00, the heart rate reached more than 200 per minute, and then transferred to the local children's hospital, delirious, manic, the current heart rate is 150 times per minute.
Test results: Sibutramine concentration in the blood 110.2 ng/mL, N-norepeptrimin and N, N-double noreperzebutramine, the latter two refer to sibutramine metabolites.
On 22 June, the heart rate was 138 beats per minute, and the blood concentration of sibutramine was 20.5 ng/ml.
Reflection review: Sibutramine can still be found in the blood of this child after six days, indicating that the drug content in the body is large, and metabolism and treatment take longer.
Date April 30
Patient Name: **Ran Age: 3 years old
Symptoms: At about 21:40 on the evening of April 29, the child ate 7 "diet pills" chocolate, clear consciousness, irritability, more talk, fever of 37.8 ° C, heart rate of 160 times per minute, the first gastric lavage at 10 pm; the second gastric lavage on the 30th, leaving hematuria at 14:00 in the afternoon. After taking sedatives, the heart rate is 110 times per minute, and there is no medical history and no history of taking drugs for half a month.
Test results: Sibutramine concentration in blood 26.3 ng/mL, sibutramine concentration in urine 138.2 ng/mL.
On May 4, the results were negative, and no sibutramine and sibutramine metabolites were found in the blood.
Alas, a 3-year-old child, washed his stomach twice in two days, suffered more ~ ~ The latter case is even worse, the brothers eat strawberry milkshake together, both poisoned!
Date April 26
Name of the child: **Feng, 4 years old,
Symptoms: Brother ** Feng ate a small bag of "strawberry milkshakes" at noon on the 26th, and began to vomit at 3 or 4 p.m., and has been vomiting non-stop, with a heart rate of 150 times per minute. After 6 hours of gastric lavage, consciousness is clear. After 10 hours, leave blood and gastric lavage. No history of other medications.
Test results: The concentration of sibutramine in the blood is 15.5 ng/mL, and the sibutramine component is detected in the gastric juice.
Name of the child: ** Jun, 2 years old
Symptoms: Brother ** Jun around 12:00 noon on the 26th and brother to eat "strawberry milkshake S", the amount is very small, did not cause vomiting, no adverse symptoms. After 6 hours of gastric lavage, clear consciousness. After 10 hours, leave blood and gastric lavage.
Test results: Sibutramine concentration in blood 9.2 ng/mL, sibutramine component detected in gastric juice.
On April 29, the two children had no obvious symptoms, a heart rate of 80, and no sibutramine and sibutramine metabolites were detected in the blood sent for testing.
Reflection review: This is a blessing for the little brothers who "suffer together", because the intake of sibutramine is small, the metabolism time in the body is short, so the drug is basically excreted after 3 days.
The child's mother specially brought a milkshake bag and sent it to everyone to see, don't look for it!
This is the "strawberry milkshake S" that the little brothers mistakenly ate.
Date April 23
Child's name: **Xin, 2 years old
Symptoms: The child's mother told that the child mistakenly ate two fat-reducing chocolates he usually ate at about 10:30 a.m. on the 22nd, and then appeared unconscious, mentally confused, sent to the hospital at 1 a.m. on the 23rd to wash the stomach, sweating, irritability, heart rate 200 times per minute, 3 o'clock left blood, urine samples, and carried a "fat-reducing chocolate" sample.
Test results: Sibutramine concentration of 42.6 ng/mL, sildenafil concentration of 54.3 ng/mL.
On the 26th, the child has been basically out of danger, but unconscious, restless, the test results show that the concentration of sildenafil in the blood is 15.1 ng /ml, the concentration of sibutramine is 8.3 ng/ml, and the midazolam component.
After the 28th re-examination, the child was basically normal, and no sibutramine, sildenafil and metabolites were detected in the blood sample.
On 4 May, the child was discharged from danger.
The child is unconscious and confused when he becomes ill
Slimming chocolate that your child ate by mistake
Very similar to everyday chocolate packaging
Parents of children feedback on their children's treatment
At that time, according to the direction of suspicion of the doctors of the Children's Hospital, our preliminary judgment was the problem of "fat-reducing chocolate", and according to the patient's irritability, sweating, rapid heart rate and other symptoms, it should be related to some stimulants, and the first thought was sibutramine, which has been banned, similar patients have seen more, so we started with sibutramine, after computer screening, blood, urine and "fat-reducing chocolate" were detected sibutramine and sildenafil.
I was very impressed by this case, which is also the basis for my quick judgment when I received this case today. In the process of flipping through this pile of case files, I was also thinking about several questions:
Why did Sibutramine, which had been suspended for many years, rise again?
Who is taking the risk? And who is losing weight with life?
Who cares about the sale of prohibited products by micro-businesses and circles of friends?
I learned that the parents in the above cases are all weight loss products bought through online channels such as WeChat business and WeChat circle of friends, and the other party has released a large number of comparative photos before and after weight loss on the Internet and circle of friends, which attracts people's hearts. These slimming products often added sibutramine prohibited ingredients, because the weight loss effect of sibutramine is more obvious and inexpensive in the short term, and there is a lack of other clear, safe and effective weight loss drugs on the market, and some unscrupulous merchants will add sibutramine to diet pills and health care products to make huge profits. Once there is a problem, it is difficult for consumers to protect their rights, and merchants will directly block consumers. These products cloaked in "slimming chocolate", "slimming shakes" and "slimming coffee" do not indicate the added drug ingredients, which brings great risks to treatment and is uncontrollable.
Fat-reducing chocolate containing the prohibited ingredients of sibutramine
Like the above case, after the child accidentally eats, it is difficult to give an effective treatment plan without professional testing. In the typical cases announced by the Beijing Municipal Public Security Bureau two years ago, consumers had hallucinations after taking DDS diet pills with sibutramine and phenolphthalein ingredients, and when cutting vegetables, they cut their hands as radishes, and all three tendons were broken. According to the hospital's diagnosis, the consumer's central nervous system was irreversible damage and required lifelong treatment. The police will follow the vine and destroy the dens where the diet pills are manufactured and sold in Hangzhou.
Some time ago, the sensational "Guo Meimei" was "two into the palace" incident because the diet pills she sold online contained the prohibited ingredients of sibutramine. Here, I can't help but advise those micro-merchants and Internet celebrities who sell various weight loss products on the Internet: selling products containing sibutramine's prohibited ingredients will be jailed, and the consequences are very serious. Even if you yourself are not afraid to bear the consequences, can you still feel at ease when you see these hurt baby angels?
Lo and behold, this is the scene when the 2-year-old ** Xin baby was treated in the hospital, the child was full of red face, restless, constantly noisy...
The two-year-old child** Xin was restless when he was treated in the hospital
The sale of fake and shoddy products in the circle of friends is hidden, and it is more difficult for law enforcement departments to investigate and deal with them, which is also the reason why some lawbreakers dare to take chances. As consumers and parents, you need to have basic identification skills and don't be gullible.
In fact, not only weight loss products, some of our common "traditional Chinese medicine" and "health care drugs" used to lower blood sugar, lower blood pressure, lower blood lipids, and treat sexual dysfunction, many of which have the illegal addition of Western medicine, so while pursuing health, we must also polish our eyes.
When writing this article, I also looked at the test cases of the group company in recent months, and found that the cases of children poisoning from diet pills in the Beijing and Shijiazhuang laboratories also had an upward trend. For families with young children in the family, if you buy these "unidentified" products, do not put them in place and do not expose them to children. Once the child is accidentally ingested, it is very likely to cause irreversible damage, and it is really regrettable at that time!